Scienmag

APRIL 27, 2022

Researchers at University of California San Diego School of Medicine and Jacobs School of Engineering, with colleagues at Baylor College of Medicine, have used a systems biology approach to parse the genetic diversity of Clostridioides difficile, a particularly problematic pathogen in health care settings.

Genetics 85

Genetics Engineer Medicine Research 85

Advarra

MARCH 31, 2023

The use of engineered genetic materials in clinical trials is rapidly expanding, with potential applications for genetic vaccines, gene-modified cellular therapies, and gene therapies. A key part of the IBC’s evaluation is assessing the risks posed by the engineered genetic materials.

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Engineer Genetics Clinical Research Research 52

Scienmag

JULY 1, 2022

Curing debilitating genetic diseases is one of the great challenges of modern medicine. During the past decade, development of CRISPR technologies and advancements in genetics research brought new hope for patients and their families, although the safety of these new methods is still of significant concern.

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Genetics Genetic Disease Medicine Development 97

Medical Xpress

MARCH 8, 2023

Combining discoveries in cancer immunology with sophisticated genetic engineering, Columbia University researchers have created a sort of "bacterial suicide squad" that targets tumors, attracting the host's own immune cells to the cancer to destroy it.

Bacteria 75

Bacteria Engineer Genetic Engineering Genetics 75

Pharmaceutical Technology

JANUARY 5, 2023

Under the multi-year strategic partnership, Prevail will detect and advance capsids, which are clinically translatable, along with its cargo to develop the transformative genetic medicines by using Capsida’s novel adeno-associated virus (AAV) engineering platform.

Gene Therapy 237

Gene Therapy Gene Development Engineer 237

Pharma Marketing Network

NOVEMBER 23, 2024

Just as a chef relies on quality ingredients for the perfect dish, marketers depend on cutting-edge research to craft campaigns that resonate with their audience. The Connection Between Pharma Research and Marketing Effective marketing starts with understanding your audience.

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Marketing Research Big Data Medicine 52

Medical Xpress

NOVEMBER 10, 2022

In recent years, genetically re-engineered immune cells—armed with molecular weaponry to recognize and destroy tumor cells—have changed the landscape of cancer treatment.

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Engineer Genetics Development Research 131

Scienmag

AUGUST 11, 2020

Assessing clinical data across the lifespan identified the impact of genetic epilepsies on affected children’s lives Philadelphia, August 11, 2020 – A team of researchers at Children’s Hospital of Philadelphia (CHOP) affiliated with the CHOP Epilepsy Neurogenetics Initiative (ENGIN) further bridged the gap between genomic information (..)

Genetics 70

Genetics Genome Genomics Engineer 70

Pharmaceutical Technology

NOVEMBER 29, 2022

Researchers at City of Hope in the US have developed a new potential therapy to treat glioblastoma multiforme (GBM), a kind of brain cancer. These viruses are engineered genetically for killing cancer. The post City of Hope researchers develop new brain cancer therapy appeared first on Pharmaceutical Technology.

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Development Research Antibody Engineer 130

Scienmag

JUNE 27, 2021

Credit: McMaster University HAMILTON, ON June 28, 2021 — Researchers at McMaster University have developed a promising new cancer immunotherapy that uses cancer-killing cells genetically engineered outside the body to find and destroy malignant tumors.

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Engineer Genetic Engineering Research Genetics 61

Advarra

JUNE 13, 2024

Recombinant DNA technologies and genetically modified biological agents are being adapted for a wide scope of therapeutic applications, and their use is becoming increasingly common in clinical trials. Synthetic mRNA-based therapeutics used in clinical research today also fall into this self-limiting class of recombinant therapeutics.

Genetic Engineering 52

Genetic Engineering Clinical Trials Clinical Trials Engineer 52

Scienmag

SEPTEMBER 10, 2021

Leveraging advancements in CRISPR-based genetic engineering, researchers at the University of California San Diego have created a new system that restrains populations of mosquitoes that infect millions each year with debilitating diseases.

Genetics 59

Genetics Genetic Engineering Engineer Research 59

Advarra

JUNE 12, 2023

Gene therapy research is exciting and full of promise, but because of the risks involved, it’s also highly regulated, requiring an institutional biosafety committee (IBC) to provide additional oversight and risk assessment. IRBs are tasked with protecting research subject’s rights and welfare. What Does an IBC Review?

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Genetic Engineering Gene Therapy Genetics Engineer 98

Scienmag

JUNE 1, 2021

UMass Amherst epidemiologist serves as a leading researcher in global collaboration Credit: UMass Amherst By ensuring ethnic diversity in a largescale genetic study, an international team of researchers, including a University of Massachusetts Amherst genetic epidemiologist, has identified more regions of the genome linked to type 2 diabetes-related (..)

Genetics 61

Genetics Research Genome Genomics 61

Pharmaceutical Technology

JUNE 4, 2023

Encoded Therapeutics develops gene therapies for the treatment of severe genetic disorders. To further understand the key themes and technologies disrupting the pharmaceutical industry, access GlobalData’s latest thematic research report on Pharmaceutical. The company is headquartered in South San Francisco, California, US.

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Gene Gene Therapy Genetics DNA 262

Pharmaceutical Technology

APRIL 20, 2023

CircRNA research and development activities are being conducted at the company’s facility at the Karolinska Institute in Stockholm, Sweden. The circVec platform is a modular genetic cassette that provides instructions for the generation of multifunctional circRNAs.

Gene Therapy 240

Gene Therapy RNA Gene Development 240

Medical Xpress

DECEMBER 5, 2022

Biomedical and genetic engineers at Duke University and the Albert Einstein College of Medicine have designed a small fluorescent protein that emits and absorbs light that penetrates deep into biological tissue.

Protein 75

Protein Genetic Engineering Research Engineer 75

BioPharma Reporter

SEPTEMBER 28, 2021

A new deal sees Bone Therapeutics gain access to iPSC derived, genetically engineered MSCs.

Genetic Engineering 72

Genetic Engineering Engineer Genetics Research 72

Pharmaceutical Technology

MAY 25, 2023

The technology platforms include the Life Edit gene editing platform, an RNA, cell, protein, vector engineering and induced pluripotent stem cells (iPSCs) platform. ElevateBio intends to use the funds to advance its genetic medicine current good manufacturing practice (cGMP) and process development business, BaseCamp.

Gene Therapy 243

Gene Therapy Gene Gene Editing Development 243

Scienmag

MARCH 15, 2021

Engineered T cells can recognize and destroy cells with loss of one gene copy Credit: Elizabeth Cook Researchers developed a prototype for a new cancer immunotherapy that uses engineered T cells to target a genetic alteration common among all cancers.

Genetics 54

Genetics Immune Response Engineer Gene 54

Scienmag

MARCH 22, 2022

Astronauts might one day grow and eat genetically modified plants to ward off disease associated with long spaceflights. Researchers at the University of California, Davis College of Engineering have developed a transgenic, or genetically modified, lettuce producing a drug to protect against bone density loss in microgravity.

Genetics 88

Genetics Engineer Development Drugs 88

Scienmag

JANUARY 18, 2021

This remains science fiction and not reality because researchers today struggle to organize cells into the complex 3D arrangements that our bodies can master on their own. Credit: Batalov et al., PNAS, 2021 Imagine going to a surgeon to have a diseased or injured organ switched out for a fully functional, laboratory-grown replacement.

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Engineer Research Genetics Medicine 94

STAT News

NOVEMBER 14, 2022

This year’s class of 28 Wunderkinds were selected from more than 200 brilliant researchers.

Bacteria 96

Bacteria Engineer Genetics Research 96

pharmaphorum

SEPTEMBER 16, 2022

Alphabet subsidiary and precision health company Verily recently announced a breakthrough in its AI drug discovery GPCR research collaboration with Sosei Heptares. Verily’s Immune Profiler platform is “a discovery engine consisting of proprietary immune profiling lab workflow, growing multi-omic database, and advanced analytical tools”.

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Development Research Drugs Clinical Trials 135

Pharmaceutical Technology

SEPTEMBER 29, 2022

The alliance will leverage the CRISPR genome editing technologies of Scribe to facilitate in genetic modification of new natural killer (NK) cell therapeutics for cancer. According to the deal, Sanofi will make an upfront payment of $25m to Scribe. Cell & Gene Therapy coverage on Pharmaceutical Technology is supported by Cytiva.

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Development In-Vivo Genome Genomics 130

Medical Xpress

JANUARY 18, 2023

Researchers at Columbia Engineering and Columbia University Irving Medical Center have invented a new RNA sequencing method that achieves high-quality results from small volumes of frozen tumor specimens. The paper was published January 9, 2023, by Nature Genetics.

RNA 98

RNA Engineer Genetics Research 98

Scienmag

NOVEMBER 12, 2021

SASKATOON – University of Saskatchewan (USask) researchers are part of a global team that used DNA to track the genetic evolution and migration of the chickpea,?offering offering insights that could lead to more nutritious and adaptable varieties.

DNA 85

DNA Research Genetics Engineer 85

XTalks

JANUARY 26, 2024

Technological advancements are revolutionizing cancer research and therapies. By editing these genes, researchers can effectively neutralize their cancer-promoting effects. By tailoring treatments based on an individual’s genetic makeup, it may allow for more effective and targeted therapies.

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Research Gene Editing Gene Genetics 118

Scienmag

OCTOBER 27, 2020

In the world of rare genetic diseases, exome and genome sequencing are two powerful tools used to make a diagnosis. A recent addition to the toolkit, RNA sequencing, has been demonstrated to help researchers narrow down disease candidate variants identified first on exome and genome sequencing.

Genetic Disease 69

Genetic Disease RNA Genetics Genome 69

Scienmag

NOVEMBER 11, 2020

Credit: Masato Kanemaki Researchers can now more accurately and precisely target specific proteins in yeast, mammalian cells and mice to study how knocking down specific protein traits can influence physical manifestation in a cell or organism. The Japan-based team published their results on November 11th in Nature Communications.

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Protein Genetics RNA Development 98

Pharmaceutical Technology

JANUARY 10, 2023

Asklepios BioPharmaceutical has entered a research partnership and option agreement with ReCode Therapeutics for exploring its single-vector gene-editing platform. Beyond the liver, ReCode’s SORT LNP genetic medicines technology enables the delivery to target cells and organs.

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Gene Editing Gene Gene Therapy Genetics 130

Scienmag

APRIL 23, 2021

This can be helpful in the study of rare genetic defects, among other things. A new VR platform enables the display of huge amounts of data. Credit: Sebastian Pirch, published in Nature Communications 2021. Networks offer a powerful way to visualize and analyze complex systems.

Genetics 92

Genetics Research Bioinformatics Gene 92

Scienmag

SEPTEMBER 29, 2021

LA JOLLA, CA—One of modern biologists’ most ambitious goals is to learn how to expand or otherwise modify the genetic code of life on Earth, in order to make new, artificial life forms. Part of the motivation for this “synthetic biology” research is to understand more about the evolution and the logic of the natural […].

Genetics 61

Genetics Research Engineer 61

Pharmaceutical Technology

FEBRUARY 14, 2023

The modified contract is backed by previously allocated federal funding from Biomedical Advanced Research and Development Authority, HHS, and the Administration for Strategic Preparedness and Response. It was developed using the recombinant nanoparticle technology of Novavax.

Vaccination 162

Vaccination Vaccine Protein Engineer 162

Scienmag

JULY 6, 2022

Researchers have solved a medical mystery in a poorly understood disease by uncovering which cells cause tumours in patients with tuberous sclerosis complex (TSC). As described in Cell Reports, they did this by creating genetically engineered kidney organoids, or “mini-kidneys” grown from human tissue.

Genetic Engineering 73

Genetic Engineering Engineer Genetics Research 73

Pharmaceutical Technology

NOVEMBER 29, 2022

For several decades, researchers have been investigating the role of ketamine in treating depression. PharmaTher also has an agreement in place with Case Western Reserve University to develop ketamine as a treatment for Rett syndrome, a rare genetic neurological disorder. Depression research spurs efforts for other conditions.

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Research Trials Drugs Generic Drugs 275

Scienmag

MAY 28, 2021

Genetics toolkit targets less researched Culex mosquitoes, which transmit West Nile virus and avian malaria Credit: Gantz Lab, UC San Diego Since the onset of the CRISPR genetic editing revolution, scientists have been working to leverage the technology in the development of gene drives that target pathogen-spreading mosquitoes such as Anopheles and (..)

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Containment Genetics Research Gene 69