Roots Analysis

FEBRUARY 15, 2022

Presently, there are several companies and universities, which are exploring the potential of different gene editing technologies beyond CRISPR for basic research, and the development of gene editing solutions. Genome Editing is a way of making changes in the DNA. Genome Editing is a way of making changes in the DNA.

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Genome Genomics Gene Editing DNA 52

Scienmag

FEBRUARY 14, 2022

This “lossiness” largely preserves the image while vastly reducing its file size — and serves as the inspiration for a new research direction in genomics, according to Justin Pritchard, assistant professor of biomedical engineering. […].

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Research Gene Genome Genomics 88

STAT News

MARCH 14, 2023

Saying genetics researchers inconsistently and inappropriately use racial and ethnic labels that fail to capture the complex patterns of human genetic variation, the National Academies of Sciences, Engineering, and Medicine issued a report Tuesday calling for a transformation in how such descriptors are used. Read the rest…

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Genetics Research Genome Genomics 98

Scienmag

JANUARY 13, 2021

To discover these associations, researchers need to compare the genomes of many individuals at millions of genetic locations or markers, and therefore require cost-effective genotyping technologies. A new statistical method, developed […].

Genome 57

Genome Genomics Genotype Genetics 57

BioTech 365

MARCH 29, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Study reports six novel variants for CRISPR-Cas12a in plants, expanding genome engineering.In

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Pharmaceutical Technology

SEPTEMBER 29, 2022

The alliance will leverage the CRISPR genome editing technologies of Scribe to facilitate in genetic modification of new natural killer (NK) cell therapeutics for cancer. According to the deal, Sanofi will make an upfront payment of $25m to Scribe. Cell & Gene Therapy coverage on Pharmaceutical Technology is supported by Cytiva.

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The Pharma Data

JANUARY 31, 2021

(NASDAQ: ILMN), the global leader in DNA sequencing and array-based technologies, and Sequoia Capital China , a leading investment firm, today announced a collaboration to catalyze the startup ecosystem in China with the launch of the Sequoia Capital China Intelligent Healthcare Genomics Incubator, Powered by Illumina.

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BioTech 365

SEPTEMBER 21, 2020

In a leap forward for immune privileged cell and organ therapy, researchers create first clinical xenotransplantation prototype with enhanced human immune compatibility and without active porcine endogenous retrovirus (PERV) Results published in Nature Biomedical Engineering demonstrate potential of Qihan’s genome … Continue reading → (..)

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Scienmag

JANUARY 5, 2022

SAN FRANCISCO, CA—January 5, 2021—Over the past decade, the CRISPR genome-editing system has revolutionized molecular biology, giving scientists the ability to alter genes inside living cells for research or medical applications.

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Gene Gene Editing Research Genome 87

pharmaphorum

SEPTEMBER 16, 2022

Alphabet subsidiary and precision health company Verily recently announced a breakthrough in its AI drug discovery GPCR research collaboration with Sosei Heptares. Verily’s Immune Profiler platform is “a discovery engine consisting of proprietary immune profiling lab workflow, growing multi-omic database, and advanced analytical tools”.

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Scienmag

APRIL 26, 2021

Credit: Scuba Zoo A study led by researchers at the Centre for Palaeogenetics in Stockholm shows that the last remaining populations of the Sumatran rhinoceros display surprisingly low levels of inbreeding.

Genome 53

Genome Genomics Genetics Research 53

WCG Clinical

NOVEMBER 17, 2023

Originally released in 1976, the NIH Guidelines for Research Involving Recombinant or Synthetic Nucleic Acid Molecules ( NIH Guidelines ) serve as the foundation of biosafety-focused oversight of research involving recombinant or synthetic nucleic acids (rsNA). Since then, however, certain genetic engineering technologies (e.g.,

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Scienmag

SEPTEMBER 10, 2020

Computational method capable of decoding influence of rare variants Geneticists could identify the causes of disorders that currently go undiagnosed if standard practices for collecting individual genetic information were expanded to capture more variants that researchers can now decipher, concludes new Johns Hopkins University research.

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Genetic Analysis Genetics Genome Genomics 50

Pharmaceutical Technology

JUNE 23, 2022

Researchers at the University of New Hampshire (UNH) have found that a repurposed drug, CCG-50014, could hinder the activity of a key enzyme of the SARS-CoV-2 virus, which causes Covid-19. Mpro has become the main focus of intense research and treatment development as it is vital for viral replication.

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Scienmag

FEBRUARY 21, 2021

‘Exploring one of the biggest challenges facing genomics today – understanding genetic variants’ SEATTLE (February 22, 2021) – Global experts performing leading edge research in precision medicine, functional genomics, protein science, and variant interpretation and prediction will share their expertise and insights April 5-7 (..)

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WCG Clinical

AUGUST 27, 2024

The NIH Guidelines also stipulate that at least two members of each IBC come from the surrounding community and be unaffiliated with the institution where the research is occurring apart from their membership on the IBC. Many of those original concerns of the 1970s and 1980s surrounding genetic engineering have lessened over time.

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Genetic Engineering Engineer Compliance Genetics 52

XTalks

AUGUST 29, 2022

CRISPR is notable for engineering living cells, allowing scientists to edit, turn off, delete, or replace genes in a cell’s genome. It is difficult to control where the viral vectors insert genes in the genome, and it is difficult to manufacture large quantities of clinical-grade viral vectors.

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Gene Editing DNA Gene Genome 88

pharmaphorum

MARCH 24, 2022

LifeMine has developed an industrialised, genomics-based discovery engine that it hopes will take a broad, systematic approach to identifying new compounds from fungi and screening them for activity against disease targets. Image by jggrz from Pixabay .

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Medicine Genome Genomics Engineer 105

Scienmag

JUNE 1, 2021

UMass Amherst epidemiologist serves as a leading researcher in global collaboration Credit: UMass Amherst By ensuring ethnic diversity in a largescale genetic study, an international team of researchers, including a University of Massachusetts Amherst genetic epidemiologist, has identified more regions of the genome linked to type 2 diabetes-related (..)

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Genetics Research Genome Genomics 79

Pharmaceutical Technology

MAY 17, 2023

Prevail will pay for research funding and tiered royalties on net future sales while Scribe will have the right to opt-in to co-fund and share profits in the US on a single collaboration programme from the latest partnership. “Our Scribe will receive $75m, including an upfront payment and equity investment via a convertible note.

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Scienmag

AUGUST 11, 2020

Researchers from Skoltech, Lomonosov Moscow State University, and the Kharkevich Institute for Information Transmission Problems have studied the genomes of some 200 strains of bacteria to determine which proteins in the ribosome, part of the key cell machinery, can be safely lost and why.

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Bacteria Genome Genomics Protein 41

Scienmag

MAY 27, 2021

Credit: LIU Yang Researchers from the Single-Cell Center at the Qingdao Institute of Bioenergy and Bioprocess Technology (QIBEBT) of the Chinese Academy of Sciences have developed a technique to sort and sequence the genome of bacteria in soil one bacterial cell at a time, while also identifying what its function is in the soil environment. […]. (..)

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Bacteria Development Research Genome 67

Pharmaceutical Technology

FEBRUARY 15, 2023

Innovation S-curve for the pharmaceutical industry Gene splicing using nucleases is a key innovation area in the pharmaceutical industry Nucleases play a fundamental role in the field of recombinant DNA technology, or genetic engineering. Nucleases are enzymes that hydrolytically cleave the phosphodiester backbone of DNA.

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Gene Splicing Gene DNA Recombinant DNA Technology 130

Pharmaceutical Technology

FEBRUARY 23, 2023

Moderna has entered a strategic research and development partnership with ElevateBio’s Life Edit Therapeutics to discover and develop new in-vivo mRNA gene editing therapies. Under the deal, both companies will partner on the research and preclinical studies, which will be funded by Moderna.

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Gene Editing Gene In-Vivo Gene Therapy 147

Scienmag

JUNE 25, 2021

Assistant Professor Wei Xiong honored with inaugural CALPHAD Young Leader Award Credit: Wei Xiong PITTSBURGH (June 25, 2021) … CALPHAD (CALculation of PHAse Diagrams) is one of the genomic toolkits for material design and more recently is widely used in alloy innovation, ceramic design, processing optimization, and microstructure engineering.

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Engineer Genome Genomics Development 63

Scienmag

AUGUST 11, 2020

Assessing clinical data across the lifespan identified the impact of genetic epilepsies on affected children’s lives Philadelphia, August 11, 2020 – A team of researchers at Children’s Hospital of Philadelphia (CHOP) affiliated with the CHOP Epilepsy Neurogenetics Initiative (ENGIN) further bridged the gap between genomic information (..)

Genetics 70

Genetics Genome Genomics Engineer 70

pharmaphorum

OCTOBER 4, 2022

AstraZeneca’s rare disease firm Alexion is set to expand its genomic medicine portfolio with the acquisition of gene editing specialist LogicBio Therapeutics, in a deal worth approximately $68 million.

Gene Editing 64

Gene Editing Gene Genome Genomics 64

pharmaphorum

JANUARY 29, 2021

Genome editing is an exciting but still nascent field, and companies in the area face as many obstacles as they do opportunities. ZFPs can be engineered to make zinc finger nucleases, or ZFNs, which are proteins that can be used to edit genomes by knocking select genes in or out to specifically modify DNA sequences.

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Gene Editing Gene Gene Therapy In-Vivo 145

BioTech 365

OCTOBER 15, 2020

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Synthego’s CRISPR platform enables faster ID of potential Coronavirus treatment.Synthego, the genome engineering company, has collaborated with The Krogan Lab, a world-renowned scientific research unit at the … Continue (..)

Genome 40

Genome Genomics Engineer Research 40

Scienmag

MARCH 11, 2021

The CRISPR-based gene editor, C-to-G Base Editor (CGBE), opens up treatment avenues for up to 40 per cent of genetic disorders caused by single-nucleotide mutations Credit: Agency for Science, Technology and Research (A*STAR), Genome Institute of Singapore (GIS) A team of researchers from the Agency for Science, Technology and Research’s (A*STAR) (..)

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Gene Scientist Genome Genomics 74

Pharmaceutical Technology

JUNE 4, 2023

AAV genomes are highly compact, with overlapping coding regions, alternate splicing schemes, and multiple transcription initiation codons. There are two main genes in the AAV genome, rep and cap, which encode nine different proteins. Pfizer and Biogen stand in second and third positions, respectively.

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Gene Gene Therapy Genetics DNA 262

pharmaphorum

JANUARY 5, 2023

and OriCiro Genomics K.K. He continued: “OriCiro’s technology strategically complements our manufacturing expertise and further accelerates our research and development engine.”. Biotech Moderna, Inc. have announced they have entered into a definitive agreement for Moderna to acquire OriCiro at a cost of $85 million.

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Gene Sequencing DNA Vaccination Vaccine 97

The Pharma Data

JANUARY 19, 2021

In the paper, researchers from Johns Hopkins University and elsewhere found a natural long-form transactivating CRISPR RNA (tracr-L) in Streptococcus pyogenes that functions to downregulate its endogenous CRISPR-Cas9 system. But altering the tracr-L with genetic engineering to make it function more like a guide RNA increased CRISPR-Cas9 cuts.

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Bacteria Gene Editing Research RNA 52

Pharmaceutical Technology

MARCH 8, 2023

The new technologies will also overcome the manufacturing bottlenecks in delivering advanced engineered cell products. Its focus areas include human systems, precision diagnostics, data sciences, next-generation biomanufacturing, and genomic medicines.

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Gene Therapy Manufacturing Gene Production 244

Scienmag

MARCH 26, 2021

International genomics research led by the University of Leicester has used artificial intelligence (AI) to study an aggressive form of cancer, which could improve patient outcomes.

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Genome Genomics Research Genetics 74

The Pharma Data

MARCH 31, 2023

The researchers said the AI tool, dubbed CLEAN, outperforms the leading state-of-the-art tools in accuracy, reliability and sensitivity. Better understanding of enzymes and their functions would be a boon for research in genomics, chemistry, industrial materials, medicine, pharmaceuticals and more. Source link: [link]

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Protein Genome Genomics Engineer 40

The Pharma Data

DECEMBER 17, 2020

The Alliance for Lupus Research ( LRA) President and Chief Executive Officer Kenneth M. We are particularly proud to see this approval for another indication of belimumab, having funded much of the original research that led to the drug’s development. When Pigs Fly Allergy-friendly.

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FDA Approval Genome Genomics Production 52