Pharmaceutical Technology

MAY 25, 2023

The technology platforms include the Life Edit gene editing platform, an RNA, cell, protein, vector engineering and induced pluripotent stem cells (iPSCs) platform. ElevateBio intends to use the funds to advance its genetic medicine current good manufacturing practice (cGMP) and process development business, BaseCamp.

Gene Therapy 243

Gene Therapy Gene Gene Editing Development 243

BioTech 365

OCTOBER 28, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Engineers devise a way to selectively turn on RNA therapies in human cells.Researchers at MIT and Harvard University have designed a way to selectively turn on gene … Continue reading →

RNA 40

RNA Engineer Gene Research 40

Scienmag

OCTOBER 27, 2020

A recent addition to the toolkit, RNA sequencing, has been demonstrated to help researchers narrow down disease candidate variants identified first on exome and genome sequencing. In the world of rare genetic diseases, exome and genome sequencing are two powerful tools used to make a diagnosis.

Genetic Disease 69

Genetic Disease RNA Genetics Genome 69

Medical Xpress

JANUARY 18, 2023

Researchers at Columbia Engineering and Columbia University Irving Medical Center have invented a new RNA sequencing method that achieves high-quality results from small volumes of frozen tumor specimens.

RNA 98

RNA Engineer Genetics Research 98

BioSpace

FEBRUARY 24, 2021

Orna, which began as an academic query at the Massachusetts Institute of Technology (MIT), is a biotechnology company creating fully engineered circular RNA, or O-shaped RNA therapies for the treatment of cancer, autoimmune, and genetic disorders.

RNA 69

RNA Engineer Genetics 69

Scienmag

DECEMBER 16, 2020

New research from the Whitehead Institute suggests that the products of transcription — RNA molecules — regulate their own production through a feedback loop Credit: Jon Henninger/Whitehead Institute At any given moment in the human body, in about 30 trillion cells, DNA is being “read” into molecules of messenger RNA, the intermediary (..)

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RNA DNA Regulation Production 52

Scienmag

SEPTEMBER 30, 2020

Researchers engineer RNA-targeting compounds that disable the pandemic coronavirus’ replication engine Credit: Scott Wiseman for Scripps Research JUPITER, FL – Sept.

Engineer 68

Engineer RNA Research Drugs 68

Scienmag

AUGUST 20, 2020

Some of these structures, such as those found in DNA, RNA and proteins, are formed through complex molecular interactions that are not easily duplicated by inorganic materials. A research team led by Richard Robinson, associate professor of materials science and engineering, discovered a […].

Research 75

Research RNA DNA Engineer 75

XTalks

AUGUST 10, 2021

The test was developed by researchers at the Wyss Institute for Biologically Inspired Engineering at Harvard University, the Massachusetts Institute of Technology (MIT) and several Boston area hospitals. A porous membrane was engineered to capture RNA on its surface. Image source: Wyss Institute at Harvard University.

RNA 105

RNA Containment DNA Engineer 105

Advarra

MARCH 31, 2023

The use of engineered genetic materials in clinical trials is rapidly expanding, with potential applications for genetic vaccines, gene-modified cellular therapies, and gene therapies. A key part of the IBC’s evaluation is assessing the risks posed by the engineered genetic materials. Why Does the IBC Need to do a Risk Assessment?

Engineer 52

Engineer Genetics Clinical Research Research 52

pharmaphorum

OCTOBER 5, 2022

Sanofi has added to its rare disease pipeline by licensing an antibody-RNA conjugate (ARC) for facioscapulohumeral muscular dystrophy (FSHD), a genetic muscle disorder, from US biotech miRecule. billion deal in 2018.

RNA 105

RNA Genetics Dermatology Antibody 105

Roots Analysis

OCTOBER 22, 2023

RNA therapeutics are a novel class of biopharmaceuticals that harness the power of RNA molecules for the treatment and prevention of a wide range of disorders, including oncological, and genetic disorders as well as infectious diseases. Non-coding RNAs include antisense oligonucleotides (ASOs) and RNA aptamers.

RNA 40

RNA Protein Genetics Gene Expression 40

Roots Analysis

OCTOBER 30, 2023

In the past few years, Next Generation RNA therapeutics have emerged as one of the key therapeutic modalities in the modern healthcare industry. These RNA based therapeutics play a crucial role in protein production and regulation of gene functions.

RNA 40

RNA Vaccination Vaccine Development 40

XTalks

OCTOBER 21, 2020

Related: Study Dispels Claim that COVID-19-Causing Coronavirus is Lab-Engineered. In addition, Berrio and colleagues discovered other novel targets of positive selection, namely within genes encoding Nsp4 and Nsp16, which are viral enterotoxins important for the stability of the RNA structure of the virus.

RNA 98

RNA Protein Genomics Genome 98

Pharmaceutical Technology

JUNE 23, 2022

Coronaviruses, like Covid-19, are a notorious group of infectious agents that include a large class of viruses with RNA genomes, similar to the human DNA genome, that depend on well-organised protein structures crucial for viral growth and replication.

Drugs 130

Drugs Protein Genomics Genome 130

Outsourcing Pharma

JANUARY 30, 2023

The biotech company emerges with financial banking to support its 3D RNA structure engine.

RNA 52

RNA Engineer Drugs Regulation 52

Scienmag

NOVEMBER 11, 2020

“Conditional gene knockout and small interfering RNA […]. Credit: Masato Kanemaki Researchers can now more accurately and precisely target specific proteins in yeast, mammalian cells and mice to study how knocking down specific protein traits can influence physical manifestation in a cell or organism.

Protein 98

Protein Genetics RNA Development 98

pharmaphorum

JANUARY 5, 2023

However, its messenger RNA (mRNA) platform – building on continuous advances in basic and applied mRNA science – permits the development of therapeutics and vaccines for other infectious diseases, immune-oncology, rare diseases, cardiovascular diseases, and auto-immune diseases as well.

Gene Sequencing 97

Gene Sequencing DNA Vaccination Vaccine 97

XTalks

AUGUST 5, 2020

In recent webinars by Genuity Science, formerly known as WuXi NextCODE, experts from the biotech and pharma industries spoke about leveraging the power of single cell RNA sequencing platforms and solutions in conjunction with machine learning technologies such as AI in cell biology and disease research. The Power of Single Cell Technology.

Gene Expression 112

Gene Expression Development RNA Drugs 112

XTalks

JANUARY 21, 2025

From non-invasive cancer diagnostics to life-saving cardiovascular implants, the latest medical devices cleared or approved by the FDA in 2024 reflect the remarkable strides in science and engineering. A positive or negative result is determined based on the combined analysis of selected RNA biomarkers, hemoglobin levels and smoking status.

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FDA Approval Manufacturing Development RNA 105

Pharmaceutical Technology

FEBRUARY 23, 2023

Moderna Genomics general manager and chief scientific officer Eric Huang said: “Through our collaboration with Life Edit, we hope to harness the power of gene editing technologies as part of our broader research and development engine, helping to advance our mission and deliver on the promise of mRNA.”

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Gene Editing Gene In-Vivo Gene Therapy 147

XTalks

AUGUST 29, 2022

CRISPR is notable for engineering living cells, allowing scientists to edit, turn off, delete, or replace genes in a cell’s genome. The goal of the team was to significantly increase yields of correctly engineered immune cells with CRISPR to effectively manufacture cell therapies. From the Bench to Patient Therapeutics.

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Gene Editing DNA Gene Genomics 98

pharmaphorum

APRIL 28, 2022

Harness Safe & Efficacious Lipid-Based Delivery for Novel Therapeutics Beyond RNA & Hepatic Tissue. The Next Generation Lipid-Based Nanoparticles Delivery Summit is your definitive industry-led meeting to design and engineer 2nd generation of lipid nanoparticles for emerging payloads beyond RNA into clinic.

RNA 52

RNA Drug Delivery Engineer Gene Therapy 52

Scienmag

OCTOBER 7, 2020

Computational algorithms enable identification and optimization of RNA-based tools for myriad applications DNA and RNA have been compared to “instruction manuals” containing the information needed for living “machines” to operate.

RNA 69

RNA DNA Containment Bioinformatics 69

Scienmag

FEBRUARY 7, 2022

It folds the RNA of the virus into a compact structure. The SARS-CoV-2 nucleoprotein is the main protein in viral particles. This is needed to transfer the hereditary material to the “next generations” of virions (viral particles) before they are separated from the infected cell.

Antibody 82

Antibody RNA Protein Development 82

Scienmag

FEBRUARY 4, 2021

Emerging technologies harnessed to develop a faster, cheaper, and more accurate test for these hard-to-diagnose tumors, researchers report in The Journal of Molecular Diagnostics Credit: Tony Ng, MD, PhD, The University of British Columbia Philadelphia, February 4, 2021 – Researchers have leveraged the latest advances in RNA technology and machine (..)

RNA 76

RNA Development Research Genetics 76

pharmaphorum

FEBRUARY 3, 2021

These treatments are examples of patient-specific, engineered chimeric antigen receptor (CAR)-T cell therapies that harness the immune system to target and eliminate cancer cells. Thus, the availability of universal, “off-the-shelf” engineered T cells presents an attractive alternative.

Gene Editing 98

Gene Editing Gene DNA Engineer 98

pharmaphorum

JANUARY 10, 2023

The alliance has also yielded a computer vision system to improve the accuracy and speed of immune response evaluations, and a platform that has improved the success rate and throughput of DNA/RNA synthesis.

Vaccination 116

Vaccination Vaccine Clinical Trials Clinical Trials 116

Scienmag

APRIL 21, 2021

Targeting an RNA to interrupt its activity could improve patient response to therapy and increase their overall survival. […]. Credit: Yutaka Kondo Nagoya University researchers and colleagues in Japan have uncovered a molecular pathway that enhances chemotherapy resistance in some pancreatic cancer patients.

RNA 70

RNA Gene Regulation Research 70

Delveinsight

SEPTEMBER 14, 2021

ADARx bags USD 75 Million to advance its RNA tech pipeline. ADARx Pharmaceuticals, a biotechnology company developing RNA targeting therapeutics , announced the completion of a USD 75 million Series B financing to progress its drug development pipeline. SR One Capital Management and OrbiMed Advisors co-led Series B. Simeon George, M.D.,

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RNA Clinical Trials Clinical Trials Drugs 67

The Pharma Data

OCTOBER 19, 2020

Spectrum’s self-contained saliva collection kit provides critical sample consistency while suspending and neutralizing viral RNA transcripts completely inactivating the live virus. Qualified commercial RNA extraction chemistries include Perkin Elmer, Thermo Fisher, Roche, and Qiagen. ABOUT SPECTRUM SOLUTIONS AND SPECTRUM DNA.

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RNA DNA Engineer Packaging 52

XTalks

OCTOBER 8, 2024

In a statement , the Nobel Assembly said the laureates discovered a new class of non-coding RNA molecules that play a crucial role in gene regulation. To activate these instructions, cells create a copy called messenger RNA (mRNA), which exits the nucleus and directs the cell’s machinery to produce a specific protein.

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Regulation Genetics Scientist RNA 52

Scienmag

MAY 7, 2021

Georgia Tech and Emory researchers use ultrasound to develop delivery system for potent RNA drugs Credit: Ashley Ritchey, Georgia Tech RNA-based drugs have the potential to change the standard of care for many diseases, making personalized medicine a reality.

RNA 52

RNA Manufacturing Medicine Drugs 52

XTalks

NOVEMBER 22, 2021

Related: How RNA-Based Pesticides Can Improve Pest Control. During their two-week larval stage, the flies consume all the food they will need for the duration of their lives. After another two weeks, the flies enter adulthood for five to nine days, spending their time solely on creating the next generation of Black Soldier flies.

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Protein RNA Engineer Production 98

The Pharma Data

JANUARY 19, 2021

In the paper, researchers from Johns Hopkins University and elsewhere found a natural long-form transactivating CRISPR RNA (tracr-L) in Streptococcus pyogenes that functions to downregulate its endogenous CRISPR-Cas9 system. But altering the tracr-L with genetic engineering to make it function more like a guide RNA increased CRISPR-Cas9 cuts.

Bacteria 52

Bacteria Gene Editing Research RNA 52

Scienmag

OCTOBER 16, 2020

Credit: TMIMS RNA interference is a gene regulatory mechanism in which the expression of specific genes is downregulated by endogenous microRNAs or by small interfering RNAs (siRNAs). Although siRNAs have broad potential for gene-silencing therapy, their instability is one of the difficulties to develop siRNA-based agents.

Gene Silencing 57

Gene Silencing RNA Gene Development 57

XTalks

NOVEMBER 30, 2023

Over 26 weeks of Sunlenca combined with other antiretroviral drugs, 81 percent of participants achieved HIV RNA suppression, reaching levels low enough to be considered undetectable. In a study where the antiviral activity of Sunlenca was evaluated in combination with an optimized background regimen, 87.5 percent in the placebo group.

FDA Approval 111

FDA Approval Gene Therapy Gene Clinical Trials 111