BioTech 365

OCTOBER 28, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Engineers devise a way to selectively turn on RNA therapies in human cells.Researchers at MIT and Harvard University have designed a way to selectively turn on gene … Continue reading →

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RNA Engineer Gene Research 40

Scienmag

OCTOBER 27, 2020

A recent addition to the toolkit, RNA sequencing, has been demonstrated to help researchers narrow down disease candidate variants identified first on exome and genome sequencing. In the world of rare genetic diseases, exome and genome sequencing are two powerful tools used to make a diagnosis.

Genetic Disease 69

Genetic Disease RNA Genetics Genome 69

Medical Xpress

JANUARY 18, 2023

Researchers at Columbia Engineering and Columbia University Irving Medical Center have invented a new RNA sequencing method that achieves high-quality results from small volumes of frozen tumor specimens.

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RNA Engineer Genetics Research 98

BioSpace

FEBRUARY 24, 2021

Orna, which began as an academic query at the Massachusetts Institute of Technology (MIT), is a biotechnology company creating fully engineered circular RNA, or O-shaped RNA therapies for the treatment of cancer, autoimmune, and genetic disorders.

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RNA Engineer Genetics 69

Scienmag

DECEMBER 16, 2020

New research from the Whitehead Institute suggests that the products of transcription — RNA molecules — regulate their own production through a feedback loop Credit: Jon Henninger/Whitehead Institute At any given moment in the human body, in about 30 trillion cells, DNA is being “read” into molecules of messenger RNA, the intermediary (..)

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RNA DNA Regulation Production 52

Scienmag

SEPTEMBER 30, 2020

Researchers engineer RNA-targeting compounds that disable the pandemic coronavirus’ replication engine Credit: Scott Wiseman for Scripps Research JUPITER, FL – Sept.

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Engineer RNA Research Drugs 68

Scienmag

AUGUST 20, 2020

Some of these structures, such as those found in DNA, RNA and proteins, are formed through complex molecular interactions that are not easily duplicated by inorganic materials. A research team led by Richard Robinson, associate professor of materials science and engineering, discovered a […].

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Research RNA DNA Engineer 75

XTalks

AUGUST 10, 2021

The test was developed by researchers at the Wyss Institute for Biologically Inspired Engineering at Harvard University, the Massachusetts Institute of Technology (MIT) and several Boston area hospitals. A porous membrane was engineered to capture RNA on its surface. Image source: Wyss Institute at Harvard University.

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RNA Containment DNA Engineer 105

pharmaphorum

OCTOBER 5, 2022

Sanofi has added to its rare disease pipeline by licensing an antibody-RNA conjugate (ARC) for facioscapulohumeral muscular dystrophy (FSHD), a genetic muscle disorder, from US biotech miRecule. billion deal in 2018.

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RNA Genetics Dermatology Antibody 105

Roots Analysis

OCTOBER 30, 2023

In the past few years, Next Generation RNA therapeutics have emerged as one of the key therapeutic modalities in the modern healthcare industry. These RNA based therapeutics play a crucial role in protein production and regulation of gene functions.

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RNA Vaccination Vaccine Development 40

Pharmaceutical Technology

JUNE 23, 2022

Coronaviruses, like Covid-19, are a notorious group of infectious agents that include a large class of viruses with RNA genomes, similar to the human DNA genome, that depend on well-organised protein structures crucial for viral growth and replication.

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Drugs Protein Genome Genomics 130

Outsourcing Pharma

JANUARY 30, 2023

The biotech company emerges with financial banking to support its 3D RNA structure engine.

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RNA Engineer Drugs Regulation 52

Scienmag

NOVEMBER 11, 2020

“Conditional gene knockout and small interfering RNA […]. Credit: Masato Kanemaki Researchers can now more accurately and precisely target specific proteins in yeast, mammalian cells and mice to study how knocking down specific protein traits can influence physical manifestation in a cell or organism.

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Protein Genetics RNA Development 98

XTalks

AUGUST 5, 2020

In recent webinars by Genuity Science, formerly known as WuXi NextCODE, experts from the biotech and pharma industries spoke about leveraging the power of single cell RNA sequencing platforms and solutions in conjunction with machine learning technologies such as AI in cell biology and disease research. The Power of Single Cell Technology.

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Gene Expression Development RNA Drugs 112

XTalks

JANUARY 21, 2025

From non-invasive cancer diagnostics to life-saving cardiovascular implants, the latest medical devices cleared or approved by the FDA in 2024 reflect the remarkable strides in science and engineering. A positive or negative result is determined based on the combined analysis of selected RNA biomarkers, hemoglobin levels and smoking status.

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FDA Approval Manufacturing Development RNA 105

Pharmaceutical Technology

FEBRUARY 23, 2023

Moderna Genomics general manager and chief scientific officer Eric Huang said: “Through our collaboration with Life Edit, we hope to harness the power of gene editing technologies as part of our broader research and development engine, helping to advance our mission and deliver on the promise of mRNA.”

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Gene Editing Gene In-Vivo Gene Therapy 147

XTalks

AUGUST 29, 2022

CRISPR is notable for engineering living cells, allowing scientists to edit, turn off, delete, or replace genes in a cell’s genome. The goal of the team was to significantly increase yields of correctly engineered immune cells with CRISPR to effectively manufacture cell therapies. From the Bench to Patient Therapeutics.

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Gene Editing DNA Gene Genome 98

Scienmag

OCTOBER 7, 2020

Computational algorithms enable identification and optimization of RNA-based tools for myriad applications DNA and RNA have been compared to “instruction manuals” containing the information needed for living “machines” to operate.

RNA 69

RNA DNA Containment Bioinformatics 69

Scienmag

FEBRUARY 7, 2022

It folds the RNA of the virus into a compact structure. The SARS-CoV-2 nucleoprotein is the main protein in viral particles. This is needed to transfer the hereditary material to the “next generations” of virions (viral particles) before they are separated from the infected cell.

Antibody 82

Antibody RNA Protein Development 82

Scienmag

FEBRUARY 4, 2021

Emerging technologies harnessed to develop a faster, cheaper, and more accurate test for these hard-to-diagnose tumors, researchers report in The Journal of Molecular Diagnostics Credit: Tony Ng, MD, PhD, The University of British Columbia Philadelphia, February 4, 2021 – Researchers have leveraged the latest advances in RNA technology and machine (..)

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RNA Development Research Genetics 76

Scienmag

APRIL 21, 2021

Targeting an RNA to interrupt its activity could improve patient response to therapy and increase their overall survival. […]. Credit: Yutaka Kondo Nagoya University researchers and colleagues in Japan have uncovered a molecular pathway that enhances chemotherapy resistance in some pancreatic cancer patients.

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RNA Gene Regulation Research 70

Delveinsight

SEPTEMBER 14, 2021

ADARx bags USD 75 Million to advance its RNA tech pipeline. ADARx Pharmaceuticals, a biotechnology company developing RNA targeting therapeutics , announced the completion of a USD 75 million Series B financing to progress its drug development pipeline. SR One Capital Management and OrbiMed Advisors co-led Series B. Simeon George, M.D.,

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RNA Clinical Trials Clinical Trials Drugs 67

The Pharma Data

OCTOBER 19, 2020

Spectrum’s self-contained saliva collection kit provides critical sample consistency while suspending and neutralizing viral RNA transcripts completely inactivating the live virus. Qualified commercial RNA extraction chemistries include Perkin Elmer, Thermo Fisher, Roche, and Qiagen. ABOUT SPECTRUM SOLUTIONS AND SPECTRUM DNA.

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RNA DNA Engineer Packaging 52

Scienmag

MAY 7, 2021

Georgia Tech and Emory researchers use ultrasound to develop delivery system for potent RNA drugs Credit: Ashley Ritchey, Georgia Tech RNA-based drugs have the potential to change the standard of care for many diseases, making personalized medicine a reality.

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RNA Manufacturing Medicine Drugs 52

XTalks

NOVEMBER 22, 2021

Related: How RNA-Based Pesticides Can Improve Pest Control. During their two-week larval stage, the flies consume all the food they will need for the duration of their lives. After another two weeks, the flies enter adulthood for five to nine days, spending their time solely on creating the next generation of Black Soldier flies.

Protein 98

Protein RNA Engineer Production 98

The Pharma Data

JANUARY 19, 2021

In the paper, researchers from Johns Hopkins University and elsewhere found a natural long-form transactivating CRISPR RNA (tracr-L) in Streptococcus pyogenes that functions to downregulate its endogenous CRISPR-Cas9 system. But altering the tracr-L with genetic engineering to make it function more like a guide RNA increased CRISPR-Cas9 cuts.

Bacteria 52

Bacteria Gene Editing Research RNA 52

Scienmag

OCTOBER 16, 2020

Credit: TMIMS RNA interference is a gene regulatory mechanism in which the expression of specific genes is downregulated by endogenous microRNAs or by small interfering RNAs (siRNAs). Although siRNAs have broad potential for gene-silencing therapy, their instability is one of the difficulties to develop siRNA-based agents.

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Gene Silencing RNA Gene Development 57

Scienmag

FEBRUARY 19, 2021

Such is the case for exosomes, small vesicles released by cells that contain genetic materials called “RNA” and various proteins. The […].

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RNA Containment Protein Genetics 52

XTalks

FEBRUARY 3, 2022

Related: Eli Lilly Pursues RNA Editing in New Partnership with ProQR. Lilly said it chose Concord “because of the manufacturing technology experience of the local labor force; its proximity to universities with strong science, technology, engineering and math (STEM) programs; and its access to major transportation infrastructure.”.

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Manufacturing RNA Life Science Antibody 52

Roots Analysis

MARCH 16, 2023

The IVT mRNAs are structurally similar to natural mRNAs, these synthetic mRNAs can be used to express proteins through genetic engineering. Cancer Immunotherapies : RNA molecules, such as siRNA, microRNA, and mRNA, have shown tremendous potential for immunomodulation and use as a cancer immunotherapy.

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Vaccination Vaccine DNA Protein 52

Bioengineer

JULY 23, 2021

Credit: Texas A&M Engineering. The team has recently submitted a patent disclosure with the Texas A&M Engineering Experiment Station. Video credit: Dr. Abhishek Jain/Texas A&M Engineering. Team identifies crucial interaction between platelets and tumors for the first time. Original Source. https:/ / today.

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Engineer Gene Editing Clinical Trials Clinical Trials 52

pharmaphorum

JUNE 28, 2022

Building on the success of previous years of the RNA Portfolio, the 2nd Annual Oligonucleotide Therapeutics and Delivery Conference will bring together industry experts from big pharma and leading biotechs to gain an expert and holistic view on the latest developments of the industry.

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RNA Development Engineer Clinical Trials 52

The Pharma Data

DECEMBER 8, 2020

The company’s product candidates consist of novel human cells engineered to produce the crucial proteins, enzymes or factors needed by patients living with chronic diseases such as hemophilia, diabetes and lysosomal storage disorders. Laying down a new track for RNA processing, Remix launched with $81 million in financing.

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RNA Antibody Life Science Protein 52

XTalks

FEBRUARY 11, 2021

The company is on track to fulfill the 200 million-dose order put in by the US government by May, but hopes to have more available as engineers improve systems on the go. As soon as vaccine vials began coming off the production line, engineers started analyzing how production could be made faster and better.

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Manufacturing Vaccination Vaccine DNA 52

Scienmag

APRIL 23, 2021

From RNA sequencing data that pinpoints tumor cells to their exact location to three-dimensional […].

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Research RNA Scientist Bioinformatics 41

Scienmag

APRIL 14, 2021

Histones are however very sticky to both DNA and RNA, so to ensure they are transported to the cell nucleus after synthesis and bind to the right portion of DNA to organize the chromatin, they are guarded by complexes of histone chaperones. […]. In the cell nucleus histones play a crucial role packaging DNA into chromatin.

Protein 40

Protein DNA RNA Packaging 40

pharmaphorum

JULY 11, 2022

Sanofi R&D in its core haemophilia category is advancing on three fronts – engineered proteins, RNA interference drugs and gene therapies – and highlighted results in two of those at the International Society on Thrombosis and Haemostasis (ISTH) congress over the weekend.

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Engineer Gene Therapy Sales Drugs 52