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CAR-T Cells Target Harmful B Cells in Lupus CAR-T cell technology, which uses geneticengineering to direct white blood cells to attack specific molecular targets, was originally proposed for treatment of HIV infection and hematological malignancies. In these cases B cell depletion is a feature, not a bug.
With several biologics in the pipeline, including one in early stage clinical trials for head and neck cancer, the company is positioned to engineer highly specific biologics against immune targets in the body. In 2017, the US FDAapproved a CAR-T cell treatment for young adults and children with B-cell ALL.
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