This site uses cookies to improve your experience. To help us insure we adhere to various privacy regulations, please select your country/region of residence. If you do not select a country, we will assume you are from the United States. Select your Cookie Settings or view our Privacy Policy and Terms of Use.
Cookie Settings
Cookies and similar technologies are used on this website for proper function of the website, for tracking performance analytics and for marketing purposes. We and some of our third-party providers may use cookie data for various purposes. Please review the cookie settings below and choose your preference.
Used for the proper function of the website
Used for monitoring website traffic and interactions
Cookie Settings
Cookies and similar technologies are used on this website for proper function of the website, for tracking performance analytics and for marketing purposes. We and some of our third-party providers may use cookie data for various purposes. Please review the cookie settings below and choose your preference.
Strictly Necessary: Used for the proper function of the website
Performance/Analytics: Used for monitoring website traffic and interactions
Affini-T’s platform can choose and engineer the correct immune cells to create a lasting and coordinated immuneresponse in the immunosuppressive tumour microenvironment. To act on oncogenic driver mutations, Affini-T is using engineered T-cell therapies with synthetic biology and geneediting enhancements.
Gene therapy is a new therapeutic approach in which genes are used to treat or prevent diseases. It is a comprehensive term which encompasses a large variety of therapy products including viral and bacterial vectors, plasmid DNA, human geneediting technology, and patient-specific cellular gene therapy.
That is an approach that has been tried in other groups, but so far efforts have been impeded by difficulties in producing enough cells of sufficient quality and protecting them from the patient’s immuneresponse. That implantable technology was at the heart of the Semma acquisition.
The vaccine was tested in rats and showed strong, immediate and long-lasting immuneresponses to confer protection against the disease. is an autoantigen, which means it is an endogenous antigen that triggers an immuneresponse in the body. as a potential trigger for rheumatoid arthritis.
-Proof-of-concept achieved for VY-UC to engineer donor cells without the complexities of gene-editing -Novel platform abrogates cellular immuneresponse and obviates the need for immunosuppressive drugs TAMPA, Fla. & & STOCKHOLM–(BUSINESS WIRE)–#celltherapy–Vycellix, Inc.,
These findings signify a significant step forward in the development of AGT103-T as a potential gene therapy for HIV. In 2021, the FDA granted approval to San Francisco-based Excision BioTherapeutics to start trials assessing CRISPR geneediting as a potential treatment for HIV. In November 2023, Hookipa Pharma Inc.,
The geneedit prevents the virus from performing its normal evasive maneuver: hiding out in nervous system cells in order to elude the immune system. As Pickard explained, one issue is that some candidate vaccines use only a subset of HSV components, or antigens, to try to generate an immuneresponse. MONDAY, Nov.
For example, monoclonal antibodies, a type of biologic, can selectively bind to specific targets such as proteins or cells involved in disease processes, thereby modulating immuneresponses or inhibiting disease progression.
Moderna’s COVID-19 vaccine triggers an immuneresponse in older adults. Now, a research team that is led by scientists at Harvard University have used the CRISPR-Cas9 gene-editing technology to engineer human white fat so that it shows the properties of brown fat.
those that modify the expression of an individual’s genes or repair abnormal genes) has entered clinical practice, including 11 RNA therapeutics, 2 in vivo gene therapies, and 2 gene-modified cell therapies. Almost two decades after the human genome was sequenced, a trickle of new genetic medicines (i.e.,
The more targeted, bispecific functionality of bsAbs broadens the reach of antibody-mediated therapies against both solid and haematological cancers, creating novel approaches that can induce a tumour-specific immuneresponse, target immune checkpoints, or improve payload delivery to tumour cells (Fig.
It’s widely acknowledged that optimal vaccine immunity results from engaging both humoral and cellular responses, but less attention has been given to the role of mucosal immunity in protecting against COVID-19, which is surprising considering SARS-CoV-2 enters the human body primarily through the mucosal surfaces of the upper respiratory tract.
Notably, we never modify the DNA of these cells, which avoids some of the safety concerns that have been reported with certain gene-editing technologies. From these cells we apply proprietary methods to manufacture pure populations of only the cell types which we wish to use in patients.
Gene therapy has shown promise in treating cancers that are particularly difficult to manage such as neuroblastoma and Wilms tumor using CAR-T cell therapy, CRISPR-Cas9 geneediting and RNA-based interventions to target genetic drivers of disease.
Moreover, protein-based drugs are also well tolerated inside the body, thereby reducing the chances of causing any immuneresponse in the body. With an analytical mind along with an inquisitive, obstinate and inventive personality, she brings knowledge and pivotal insights into the field of Analytical Research.
We organize all of the trending information in your field so you don't have to. Join 21,000+ users and stay up to date on the latest articles your peers are reading.
You know about us, now we want to get to know you!
Let's personalize your content
Let's get even more personalized
We recognize your account from another site in our network, please click 'Send Email' below to continue with verifying your account and setting a password.
Let's personalize your content