AuroBlog - Aurous Healthcare Clinical Trials blog

MARCH 17, 2024

US researchers examined gene expression in more than a million brain cells collected post-mortem from 191 donors. Those with schizophrenia and older adults were found to have a comparitively reduced expression of specific genes in both […]

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AuroBlog - Aurous Healthcare Clinical Trials blog

DECEMBER 15, 2022

“We observed that gene expression in the brain tissue of patients who died […]. Severe COVID-19 looks scarily like old age in the human brain, according to a postmortem analysis of 54 healthy and infected individuals.

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Medical Xpress

JANUARY 18, 2023

New research from the Department of Biomedical Informatics (DBMI) at the University of Colorado School of Medicine has identified 45 genes whose gene expression is associated with body mass index (BMI), many of which have not been previously explored in obesity research, after the researchers conducted a study using a multiethnic cohort.

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Scienmag

JANUARY 27, 2022

Researchers at Baylor College of Medicine, Yale University and other institutions have identified previously unrecognized changes in gene expression and cellular interactions in distinct cell populations in chronic obstructive pulmonary disease (COPD).

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Gene Expression Gene Medicine Research 72

Medical Xpress

FEBRUARY 3, 2023

A trio of bioengineering scientists at Ecole Polytechnique Fédérale de Lausanne has found age and gender differences in gene expression related to the circadian clock. For their paper published in the journal Science, Lorenzo Talamanca, Cédric Gobet and Felix Naef analyzed data obtained for the Genotype-Tissue Expression project.

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Scienmag

NOVEMBER 25, 2021

A team led by researchers at Baylor College of Medicine and the Czech Academy of Sciences has uncovered a new piece of the puzzle of how gene expression is orchestrated. Published in the journal Science, the findings reveal a novel mechanism that coordinates the assembly of components inside cells that control gene expression.

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Gene Expression Gene Protein Medicine 66

Scienmag

OCTOBER 1, 2020

The type and direction of the force on a cell alters gene expression by stretching different regions of DNA, researchers at University of […]. . — Tissues and cells in the human body are subjected to a constant push and pull – strained by other cells, blood pressure and fluid flow, to name a few.

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Gene Expression Gene DNA Research 70

Bio Pharma Dive

AUGUST 30, 2023

The China-based company is one of at least four young biotechs in a competitive race to use CRISPR tools to alter gene expression without changing DNA.

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BioSpace

OCTOBER 20, 2022

Kite Pharma entered into a global licensing deal with Refuge Biotechnologies to leverage the latter's propriety gene expression plaform and develop potential blood cancer therapies.

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Pharmaceutical Technology

MARCH 12, 2024

Enhance gene expression and reduce immune responses with Selecta Biosciences' patented method using viral vectors and nanocarriers attached to immunosuppressants. Learn more about this innovative approach for improved therapeutic outcomes.

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Gene Expression Gene Gene Therapy Immune Response 130

Scienmag

MARCH 9, 2021

CHOP researchers find small changes in RNA due to RNA editing could have a large impact on gene expression and phenotype Philadelphia, March 9, 2021–Combining computational mining of big data with experimental testing in the lab, researchers at Children’s Hospital of Philadelphia (CHOP) have identified RNA editing events that influence (..)

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Pharmaceutical Technology

JULY 29, 2022

Ultragenyx uses adeno-associated virus 8 (AAV8) gene therapy to induce stable OTC gene expression. This treatment activates the OTC gene so that ammonia can be removed from the blood. In CAMP4’s approach, regRNAs are drugged with antisense oligonucleotides to control the direction of gene expression.

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Scienmag

MARCH 11, 2021

Study marks the first time this complex has been visualized for human cells Credit: Northwestern University For the first time ever, a Northwestern University-led research team has peered inside a human cell to view a multi-subunit machine responsible for regulating gene expression.

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Gene Expression Gene Research Regulation 51

Medical Xpress

MARCH 8, 2023

Scientific evidence shows how the cognitive decline in Alzheimer's disease (AD) is caused by the buildup of amyloid beta proteins, which promote synaptic malfunction.

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Pharmaceutical Technology

NOVEMBER 28, 2022

A key natural regulator, NRF2 controls antioxidant genes’ expression. The company’s lead molecules in the oral NRF2 Activator programme have been demonstrated to substantially activate NRF2 on dosing orally, offering anti-inflammatory and antioxidant activity.

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Pharmaceutical Technology

JANUARY 19, 2023

AOC 1020 has been designed for the treatment of the underlying cause of FSHD, which is caused by the abnormal expression of a gene known as double homeobox 4 or DUX4. Avidity Biosciences’ AOC 1020 is intended to reduce the DUX4 mRNA and DUX4 protein expression in muscles in these patients.

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Gene Expression Gene Protein RNA 246

Scienmag

DECEMBER 21, 2020

LJI scientists track down control elements that govern gene expression from a distance Credit: Alex Fung LA JOLLA–The COVID-19 pandemic has highlighted how our small genetic differences can have a tremendous effect on how our bodies respond to disease. “The difference is within us,” says Vivek Chandra, Ph.D.,

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Gene Expression Gene Genetics Scientist 52

Scienmag

JUNE 24, 2022

BIRMINGHAM, Ala. While lower vertebrates can repair their adult hearts after a heart attack, mammals — including humans — cannot. The ability to regenerate dead muscle tissue in mammalian hearts disappears just a few days after birth because the heart muscle cells, called cardiomyocytes, exit the cell cycle. Credit: UAB BIRMINGHAM, Ala.

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Gene Expression Gene 76

Scienmag

SEPTEMBER 30, 2021

Crop legumes are an integral part of sustainable agriculture, as several of these species represent an important protein source for both human and animal populations. Legumes engage in a unique and beneficial interaction with a group of soil bacteria, collectively called rhizobia.

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Gene Expression Bacteria Gene Protein 80

Scienmag

JULY 6, 2022

A University of Minnesota Twin Cities-led team has developed a new technique that allows scientists and engineers to, for the first time, visualize mRNA molecules in the brains of living mice.

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BioTech 365

APRIL 20, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Algorithm maps gene expression in space.As we accumulate more and more gene-sequencing information, cell-type databases are growing in both size and complexity.

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Gene Expression Gene Gene Sequencing Research 40

Scienmag

APRIL 23, 2021

A recently published article in the Molecular Plant-Microbe Interactions journal provides new evidence that pathogens are hijacking the plant immune system to cause disease while providing insights into a newly discovered mechanism. A large variety of pathogens infect plants and cause different diseases, which can lead to reduced crop yields.

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Scienmag

JULY 12, 2021

The function of a protein can depend on its abundance in a cell. So, when investigating the properties of a new protein, it is essential to make sure that the same amount is produced by every cell. Researchers at Baylor College of Medicine and Rice University have found a new way to do just that […].

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Medical Xpress

DECEMBER 20, 2024

An international research team, including researchers at Karolinska Institutet, has mapped the genes expressed in the brain cells of people with multiple sclerosis (MS). The atlas, which is presented in the journal Neuron, is hoped to contribute to more personalized treatment of MS in the future.

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Gene Expression Gene Research Genetics 79

BioTech 365

APRIL 1, 2021

10x Genomics Puts Single Cell Analysis Within Reach of All With Low Throughput Gene Expression Kit 10x Genomics Puts Single Cell Analysis Within Reach of All With Low Throughput Gene Expression Kit Along with recent release of CellPlex, product increases … Continue reading →

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BioTech 365

OCTOBER 14, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Protein that manipulates gene expression inside the cell nucleus could inspire new RSV drugs, vaccines.Protein that manipulates gene expression inside the cell nucleus could inspire new RSV … Continue reading →

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BioTech 365

JUNE 28, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: ADA: TB vaccine repurposed in Type 1 diabetes restores gene expression in key immune cells.ADA: TB vaccine repurposed in Type 1 diabetes restores gene expression in key … Continue reading →

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BioTech 365

APRIL 9, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: MIT and UCSF researchers create CRISPR ‘on-off switch’ that controls gene expression without changing DNA.MIT and UCSF researchers create CRISPR ‘on-off switch’ that controls gene expression without … Continue reading → (..)

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Gene Expression Gene DNA Research 40

BioTech 365

JUNE 2, 2021

Resolve Biosciences Launches Commercial Molecular Cartography™ Services to Provide Scientists with Highest-Resolution View of Subcellular Gene Expression Resolve Biosciences Launches Commercial Molecular Cartography™ Services to Provide Scientists with Highest-Resolution View of Subcellular Gene Expression Company expands global footprint (..)

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Medical Xpress

NOVEMBER 24, 2022

But they are also involved in regulating the genes expressed within—and the signaling between—cells. When we consume fats (also called lipids) in our diet, they can be metabolized or stored to provide energy for the body.

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BioTech 365

JULY 28, 2021

BostonGene Announces Publication in Clinical Cancer Research Identifying the Cellular Features and Gene Expression Characteristics Underlying MRI Visibility in Prostate Cancer BostonGene Announces Publication in Clinical Cancer Research Identifying the Cellular Features and Gene Expression Characteristics Underlying MRI Visibility in … Continue (..)

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Gene Expression Gene Research 40

Scienmag

MAY 16, 2022

Just as it’s hard to understand a conversation without knowing its context, it can be difficult for biologists to grasp the significance of gene expression without knowing a cell’s environment.

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Medical Xpress

DECEMBER 13, 2022

If humans are ever going to be able to regrow damaged tissues the way lizards and fish routinely do, it will require the precise control of gene expression in time and place—otherwise you might end up with random cells growing everywhere or a new body part that never quits growing.

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Gene Therapy Gene Gene Expression Research 98

Scienmag

NOVEMBER 20, 2021

Professor Norikazu Ichihashi and his colleagues at the University of Tokyo have successfully induced gene expression from a DNA, characteristic of all life, and evolution through continuous replication extracellularly using cell-free materials alone, such as nucleic acids and proteins for the first time.

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DNA Gene Expression Genomics Genome 96

BioTech 365

DECEMBER 1, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Researchers identify key RNA “gatekeeper” in gene expression, pointing to possible new drug targets.An

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BioTech 365

APRIL 9, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: New, reversible CRISPR method can control gene expression while leaving underlying DNA sequence unchanged.Over the past decade, the CRISPR-Cas9 gene editing system has revolutionized genetic engineering, allowing … Continue (..)

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Medical Xpress

NOVEMBER 8, 2022

A gene expression-based screening assay using chimeric mice with humanized hepatocytes revealed that letrozole has a modifying effect on fibrosis-related gene expression in the hepatocytes, including YAP, CTGF, TGF-?, and CYP26A1.

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Gene Expression Gene 75