pharmaphorum

JANUARY 29, 2021

Genome editing is an exciting but still nascent field, and companies in the area face as many obstacles as they do opportunities. Then over the next two or three years, gene therapy was accepted as something that companies got involved in, and several biotechs have been bought up by big pharma.”. The genomic medicine journey.

Gene Editing 145

Gene Editing Gene Gene Therapy In-Vivo 145

BioTech 365

MARCH 24, 2021

Ocean Genomics Partners With Geninus to Co-Develop RNA-Based Biomarkers and Advance Research Ocean Genomics Partners With Geninus to Co-Develop RNA-Based Biomarkers and Advance Research PITTSBURGH–(BUSINESS WIRE)–#RNA–Ocean Genomics (Pittsburgh, PA), a world leader in AI-based gene expression analysis and RNA biomarker … Continue (..)

RNA 40

RNA Genome Genomics Gene Expression 40

BioTech 365

SEPTEMBER 9, 2020

–(BUSINESS WIRE)–Paradise Genomics announced that it has advanced the development of their whole blood-based assay for gastric cancer by translating a gene expression profile associated with the disease into a high-throughput and cost-effective real-time PCR (RT-PCR) test. NORTHBROOK, Ill.–(BUSINESS

Genome 40

Genome Genomics Gene Expression Gene 40

Scienmag

MARCH 3, 2021

Using the model organism Caenorhabditis elegans, researchers at the University of Cologne have developed an ‘aging clock’ that reads the biological age of an organism directly from its gene expression, the transcriptome.

Gene Expression 60

Gene Expression Genome Genomics Gene 60

XTalks

MAY 4, 2021

These modifications regulate gene expression without changing the sequence or structure of DNA. The tool could also prove to be safer than conventional CRISPR-based gene therapies as it does not involve DNA editing, and thus would not cause potentially harmful off-target genomic changes. Epigenetic Editing with CRISPR.

DNA 98

DNA Gene Gene Silencing Genome 98

Pharmaceutical Technology

AUGUST 11, 2022

Alnylam Pharmaceuticals and collaborators have identified rare mutations in the INHBE gene that is expressed in the liver, related to a lower waist-to-hip ratio for body mass index (BMI), which is often used as an indicator of abdominal fat and is correlated with the risk of type 2 diabetes (T2D) and coronary heart disease.

Gene 130

Gene Biobanking Gene Expression In-Vitro 130

XTalks

MARCH 7, 2024

A new workflow from BioSkryb Genomics merges extensive data from whole genome sequencing (WGS) and the focused insights gained from small, targeted panels that emphasize druggable targets. Through this, researchers can pinpoint breast cancer cell types and their phenotypic states.

Genetics 115

Genetics Hormones Genomics Genome 115

BioTech 365

SEPTEMBER 7, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: The Spatial Mouse Atlas: New insights into cell fate.High-resolution gene expression maps have been combined with single-cell genomics data to create a new resource for studying how … Continue reading →

Gene Expression 40

Gene Expression Genome Genomics Gene 40

Scienmag

JANUARY 11, 2021

These biomarkers are epigenetic, meaning they involve changes to molecular factors that regulate genome activity such as gene expression independent of DNA sequence, and can be passed down to future generations. In a […].

Gene Expression 41

Gene Expression DNA Genome Genomics 41

BioTech 365

OCTOBER 29, 2020

Presentations to highlight two of Castle’s skin cancer gene expression profile tests FRIENDSWOOD, Texas–(BUSINESS WIRE)–$CSTL #ASDP–Castle Biosciences, Inc.

Gene Expression 40

Gene Expression Genome Genomics Gene 40

The Pharma Data

FEBRUARY 24, 2022

UNC researchers now show that these two factors can directly associate with one another, modulating cancer-cell-specific programs of gene expression. ” They found that EZH2 possesses two different binding patterns on chromatin in acute leukemia cells, eliciting two distinct gene-regulatory programs (Figure 1).

Scientist 52

Scientist Gene Expression Gene Genome 52

pharmaphorum

OCTOBER 27, 2022

It can be caused by different types of mutation, including within the BRCA gene and other forms of altered gene expression. HRD impairs cells’ ability to repair structural DNA breaks, leading to additional changes in the DNA of the tumour (known as genomic instability), and how that tumour will respond to certain treatments.

Trials 94

Trials DNA Genomics Genome 94

XTalks

MAY 4, 2021

These modifications regulate gene expression without altering the sequence or structure of DNA. The tool could also prove to be safer than conventional CRISPR-based gene therapies as it does not involve DNA editing, and thus would not cause potentially harmful off-target genomic changes. Epigenome Editing with CRISPR.

DNA 52

DNA Gene Gene Silencing Genome 52

XTalks

OCTOBER 8, 2024

Essentially, microRNAs block the expression of the gene by stopping the production of the corresponding protein from mRNA’s instructions, effectively regulating which genes are “turned on” or “off” in the cell. Their ability to modulate gene expression at the RNA level provides a novel therapeutic approach for conditions.

Regulation 52

Regulation Genetics Scientist RNA 52

XTalks

MAY 12, 2021

In this episode, Ayesha discusses a new tool that uses CRISPR to modulate gene expression without editing DNA sequences. Dubbed “CRISPRoff,” the technology targets the epigenome to silence genes involved in diseases, with applications in cancer, AML and other conditions with a heritable component.

Life Science 40

Life Science Gene Expression Gene DNA 40

The Pharma Data

MARCH 7, 2022

The approach will allow researchers to understand the role individual genes play in normal cell growth and development, in aging, and in such diseases as cancer, said Shiri Levy, a postdoctoral fellow in UW Institute for Stem Cell and Regenerative Medicine (ISCRM) and the lead author of the paper.

Protein 52

Protein Gene Genome Genomics 52

Delveinsight

JULY 30, 2020

‘Genome-tuning’ biotech Omega Therapeutics snags USD 85 Million. It will push a pipeline of treatments toward the clinic as well as bankroll the recognition of new targets for genomic medicines. Omega’s platform is designed to adjust gene expression to healthy levels rather than switching genes on and off.

Genome 52

Genome Genomics Antibody Gene 52

Roots Analysis

AUGUST 31, 2023

Nutrigenomics is the science studying the relationship between human genome, nutrition and health. In part, the success of the Human Genome Project has also paved a path for the novel concept of nutrigenomics. Nutrigenomics tests are capable of determining the influence of genes on nutrient requirements and metabolism.

Genome 40

Genome Genomics Genetics Gene 40

pharmaphorum

MARCH 10, 2021

Philip Gregory, chief scientific officer at bluebird, said the latest analysis showed that the integration site of the vector was in a gene called VAMP4. VAMP4 has no known association with development of AML or with processes such as cellular proliferation or genome stability that could be linked with cancer.

Gene Therapy 59

Gene Therapy Gene Trials Gene Expression 59

Roots Analysis

AUGUST 12, 2024

Molecular diagnostic tests are advanced techniques and tools used to analyze biological markers in the genome and proteome. Molecular diagnostic tests refer to tests intended to detect specific sequences in human genomic samples, such as DNA or RNA, in order to diagnose a particular disease. What are Molecular Diagnostic Tests?

Genetics 40

Genetics Gene Expression RNA DNA 40

XTalks

JUNE 18, 2024

c-srRNA: A Temperature-Controllable Innovation Elixirgen Therapeutics’ c-srRNA platform offers a novel approach to controlling gene expression through temperature sensitivity. EXG-34217 is an autologous cell therapy, meaning it uses the patient’s own cells, modified to express ZSCAN4 and thereby extend their telomeres.

Protein 52

Protein RNA Genetics Clinical Trials 52

The Pharma Data

NOVEMBER 8, 2020

DB-OTO, Decibel’s investigational gene therapy to restore hearing in children with congenital deafness due to a deficiency in the otoferlin gene, is in preclinical studies, and Decibel expects to initiate clinical testing in 2022.

Gene Therapy 40

Gene Therapy Gene Gene Expression Genomics 40

The Pharma Data

JULY 11, 2021

Since then, there has been an increasing body of findings that the microbiome, which is sometimes also referred to as the second human genome, is not only of central importance for digestion, but also influences, if not controls, at least a large number of body functions. The immune system is mentioned particularly frequently.

Bacteria 52

Bacteria Genetics Scientist Regulation 52

XTalks

AUGUST 12, 2020

The importance of identifying and combining signatures across multiple realms, from gene expression to the proteome to the glycome, is important in the effective identification, classification and therapeutic targeting of disease in a more specified and personalized manner, and in contributing to our overall understanding of biological processes.

RNA 52

RNA Protein DNA In-Vivo 52

Pharma Marketing Network

DECEMBER 21, 2020

Almost two decades after the human genome was sequenced, a trickle of new genetic medicines (i.e., those that modify the expression of an individual’s genes or repair abnormal genes) has entered clinical practice, including 11 RNA therapeutics, 2 in vivo gene therapies, and 2 gene-modified cell therapies.

Genetics 52

Genetics Medicine Gene Therapy Marketing 52

XTalks

FEBRUARY 11, 2021

The Human Genome Project recently marked 20 years since the publication of the first full sets of human genomic sequences, an endeavor that spanned well over a decade. Today, new next-generation sequencing technologies allow for the sequencing of complex genomes within just a day or two.

Genetics 119

Genetics DNA Genome Genomics 119

XTalks

SEPTEMBER 21, 2020

Increasing KDM6A expression in male mice led them to be more resilient to the effects of amyloid beta plaques. The scientists also looked at public databases of gene expression studies through which they discovered a particularly active variant of KDM6A that is present in about 13 percent of women and seven percent of men around the world.

Gene 89

Gene Protein Gene Expression Scientist 89

XTalks

DECEMBER 24, 2020

From isolating SARS-CoV-2 in early January to sequencing its genome shortly thereafter and having a prototype vaccine against it within days, scientific process and progress have held steadfast throughout the pandemic. CRISPR are found in approximately 50 percent of sequenced bacterial genomes and nearly 90 percent of archaea genomes.

Life Science 111

Life Science Vaccination Vaccine Gene 111