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More recently, MSN reported on a Cell Genomics study where CRISPR reactivated dormant genes in patient-derived cells, restoring normal geneexpression and improving metabolic function an innovation that could address PWS at its genetic roots.
In this episode, Ayesha discusses a new tool that uses CRISPR to modulate geneexpression without editing DNA sequences. Dubbed “CRISPRoff,” the technology targets the epigenome to silence genes involved in diseases, with applications in cancer, AML and other conditions with a heritable component.
These modifications regulate geneexpression without changing the sequence or structure of DNA. The tool could also prove to be safer than conventional CRISPR-based gene therapies as it does not involve DNA editing, and thus would not cause potentially harmful off-target genomic changes. Epigenetic Editing with CRISPR.
A new workflow from BioSkryb Genomics merges extensive data from whole genome sequencing (WGS) and the focused insights gained from small, targeted panels that emphasize druggable targets. Through this, researchers can pinpoint breast cancer cell types and their phenotypic states.
These modifications regulate geneexpression without altering the sequence or structure of DNA. The tool could also prove to be safer than conventional CRISPR-based gene therapies as it does not involve DNA editing, and thus would not cause potentially harmful off-target genomic changes. Epigenome Editing with CRISPR.
Essentially, microRNAs block the expression of the gene by stopping the production of the corresponding protein from mRNA’s instructions, effectively regulating which genes are “turned on” or “off” in the cell. Their ability to modulate geneexpression at the RNA level provides a novel therapeutic approach for conditions.
c-srRNA: A Temperature-Controllable Innovation Elixirgen Therapeutics’ c-srRNA platform offers a novel approach to controlling geneexpression through temperature sensitivity. EXG-34217 is an autologous cell therapy, meaning it uses the patient’s own cells, modified to express ZSCAN4 and thereby extend their telomeres.
Work from different fields, including evolutionary biology, suggest that there are four fundamental building blocks of life: DNA and RNA (nucleic acids), protein, lipids and sugars.
The pandemic propelled the lifescience and healthcare sectors onto center stage, and they rose to the occasion against the most unprecedented health challenge in recent times. While COVID-19 has undoubtedly been the biggest story in the lifescience industry in 2020, it was a busy and positive year in many other areas.
The Human Genome Project recently marked 20 years since the publication of the first full sets of human genomic sequences, an endeavor that spanned well over a decade. Today, new next-generation sequencing technologies allow for the sequencing of complex genomes within just a day or two.
Increasing KDM6A expression in male mice led them to be more resilient to the effects of amyloid beta plaques. The scientists also looked at public databases of geneexpression studies through which they discovered a particularly active variant of KDM6A that is present in about 13 percent of women and seven percent of men around the world.
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