The Pharma Data

FEBRUARY 24, 2022

UNC researchers now show that these two factors can directly associate with one another, modulating cancer-cell-specific programs of gene expression. ” They found that EZH2 possesses two different binding patterns on chromatin in acute leukemia cells, eliciting two distinct gene-regulatory programs (Figure 1).

Scientist 52

Scientist Gene Expression Gene Genomics 52

XTalks

OCTOBER 8, 2024

To activate these instructions, cells create a copy called messenger RNA (mRNA), which exits the nucleus and directs the cell’s machinery to produce a specific protein. Despite containing the same set of genes, cells are able to differentiate due to the regulatory role of microRNAs, which control gene expression in a precise manner.

Regulation 52

Regulation Genetics Scientist RNA 52

XTalks

JUNE 18, 2024

This innovative technology, capable of carrying large protein payloads, has demonstrated potential in restoring muscular function in a mouse model of Duchenne muscular dystrophy (DMD) through the delivery of a full-length dystrophin protein.

Protein 52

Protein RNA Genetics Clinical Trials 52

XTalks

MAY 4, 2021

These modifications regulate gene expression without altering the sequence or structure of DNA. The tool could also prove to be safer than conventional CRISPR-based gene therapies as it does not involve DNA editing, and thus would not cause potentially harmful off-target genomic changes. Epigenome Editing with CRISPR.

DNA 52

DNA Gene Gene Silencing Genomics 52

pharmaphorum

MARCH 10, 2021

Philip Gregory, chief scientific officer at bluebird, said the latest analysis showed that the integration site of the vector was in a gene called VAMP4. VAMP4 has no known association with development of AML or with processes such as cellular proliferation or genome stability that could be linked with cancer.

Gene Therapy 59

Gene Therapy Gene Trials Gene Expression 59

Delveinsight

JULY 30, 2020

The drug, UCB0107, is designed to impede or decrease the buildup of tau proteins in the brain, which leads to nerve cell damage and death. ‘Genome-tuning’ biotech Omega Therapeutics snags USD 85 Million. Omega’s platform is designed to adjust gene expression to healthy levels rather than switching genes on and off.

Genomics 52

Genomics Genome Antibody Gene 52

Roots Analysis

AUGUST 31, 2023

Nutrigenomics is the science studying the relationship between human genome, nutrition and health. In part, the success of the Human Genome Project has also paved a path for the novel concept of nutrigenomics. Nutrigenomics tests are capable of determining the influence of genes on nutrient requirements and metabolism.

Genome 40

Genome Genomics Genetics Gene 40

Roots Analysis

AUGUST 12, 2024

Molecular diagnostic tests are advanced techniques and tools used to analyze biological markers in the genome and proteome. Molecular diagnostic tests refer to tests intended to detect specific sequences in human genomic samples, such as DNA or RNA, in order to diagnose a particular disease. What are Molecular Diagnostic Tests?

Genetics 40

Genetics Gene Expression RNA DNA 40

XTalks

AUGUST 12, 2020

Studies have identified the presence of two types of HIV-infected CD4+ T cells: ‘Transcriptionally inactive’ cells that do not typically produce viral RNA or viral proteins. Fucosylation is the attachment of a specific sugar molecule called fucose to proteins on the surface of cells. T Cell Glycomic Signatures in HIV.

RNA 52

RNA Protein DNA In-Vivo 52

XTalks

FEBRUARY 11, 2021

The Human Genome Project recently marked 20 years since the publication of the first full sets of human genomic sequences, an endeavor that spanned well over a decade. Today, new next-generation sequencing technologies allow for the sequencing of complex genomes within just a day or two. Martha Chase: For the Books.

Genetics 119

Genetics DNA Genomics Genome 119

XTalks

SEPTEMBER 21, 2020

It helps explain why women with the disease survive longer with less severe symptoms than men during the early stages of the Alzheimer’s, despite having the same levels of toxic amyloid beta and tau proteins in their brains. The gene, called KDM6A , is a histone demethylase that is believed to function as a tumor suppressor.

Gene 89

Gene Protein Gene Expression Scientist 89

XTalks

DECEMBER 24, 2020

From isolating SARS-CoV-2 in early January to sequencing its genome shortly thereafter and having a prototype vaccine against it within days, scientific process and progress have held steadfast throughout the pandemic. Most antibody drugs and vaccines have been developed to target parts of the spike protein. Innovations.

Life Science 111

Life Science Vaccine Vaccination Gene 111