Gene Expression and In-Vivo - Clinical Research Informer

Combining the Powers of Single Cell Sequencing and AI in Understanding Disease Biology and Drug Development

XTalks

AUGUST 5, 2020

The detailed complexity of these processes can be captured by creating models that combine correlates of gene and protein expression, providing insight into the molecular composition of tissues. Single cell sequencing has revolutionized the study of biological tissues and systems at the cellular and molecular level.

Gene Expression

Gene Expression Development RNA Drugs

Gene editing: beyond the hype

pharmaphorum

JANUARY 29, 2021

Cutting edge’ is, for once, a truly apt description when it comes to gene editing – both because the field is pushing medicine into areas we might never have dreamed possible, and because these technologies involve literally cutting DNA at a specific point in the genome. Zinc fingers. billion in funding.

Gene Editing

Gene Editing Gene Gene Therapy In-Vivo

Using gene therapy to live longer, healthier lives

Drug Discovery World

AUGUST 22, 2024

Our lead programme is a gene therapy called ER-100 which allows for expression of three transcription factors Oct-4, Sox-2, and Klf-4 (OSK) which is being tested in two optic neuropathies: non-arteritic anterior ischemic optic neuropathy (NAION) and primary open angle glaucoma (POAG).”

Gene Therapy

Gene Therapy Gene Gene Editing In-Vivo

Biologics – The Next Step in Revolutionary Medication

Roots Analysis

JANUARY 14, 2024

Expression Systems for Biologics The processes associated with the manufacturing of biopharmaceuticals are complex and require highly sterile and aseptic conditions. It is worth mentioning that in vitro gene expression requires a suitable host for the production of a specific gene product.

Contract Manufacturing

Contract Manufacturing Manufacturing Protein Bacteria

Advances in Genetic Medicine May Be Outpacing Some Clinicians’ Understanding, But Pharmaceutical Marketers Can Do Much to Address the Problem

Pharma Marketing Network

DECEMBER 21, 2020

those that modify the expression of an individual’s genes or repair abnormal genes) has entered clinical practice, including 11 RNA therapeutics, 2 in vivo gene therapies, and 2 gene-modified cell therapies. Almost two decades after the human genome was sequenced, a trickle of new genetic medicines (i.e.,

Genetics

Genetics Medicine Gene Therapy Marketing

Cell-penetrating peptides as a delivery system for oligonucleotides

Drug Discovery World

AUGUST 3, 2022

Currently, only a small number of CPP-based oligonucleotide delivery examples have been reported for in vivo application. CDMO in peptides and oligonucleotides manufacturing, Bachem, has started building a new future for oligonucleotides: solving the industry’s main challenges around capacity, sustainability and cost-effectiveness.

Bioavailability

Bioavailability In-Vivo RNA In-Vitro

Angelman Syndrome Market: Insights Into The Recent Late-Stage Drug Failures And Novel Approaches To Treating This Rare Neurogenetic Disorder

Delveinsight

JANUARY 18, 2021

Usually, only a single copy of the gene is required that too from the mother, however, in cases of AS, either the child does not get any copy, or the child receives two copies – each from mother and father. Angelman syndrome (AS) is a complex genetic rare disorder that affects the nervous system.

Marketing

Marketing Gene Drugs Protein

What the Glycome Can Tell Us About Persistent HIV Infection

XTalks

AUGUST 12, 2020

Despite the effectiveness of anti-retroviral therapy (ART) in significantly improving health, quality of life and reducing mortality among HIV-positive individuals, new research shows that persistent infections may be due to the ability of the virus to take refuge in distinct subsets of immune T cells.

RNA

RNA Protein DNA In-Vivo

Gene Switch: A Novel Platform for Switching Genes On and Off

Roots Analysis

AUGUST 31, 2023

Overview of Gene Switch The notion that genes might be turned on and off was discovered several decades ago when studies revealed that E. Gene switches are sites on genes where regulatory molecules can bind to trigger transcription process, leading to expression of a particular gene.

Gene

Gene Gene Therapy Gene Expression Regulation

Delivering on the promise of gene editing

Drug Discovery World

DECEMBER 15, 2022

These platforms all induce double strand cuts in the chromosomal DNA that can be sealed by the cell, leading to a specific gene disruption, or resulting in a new target site for inserting DNA segments. Gene editing tools can sometimes bind to unintended sites, typically because of sequence homologies and/or mismatch tolerance.

Gene Editing

Gene Editing Gene In-Vivo Genome

Fibrosis research: Advances and challenges

Drug Discovery World

JANUARY 24, 2024

Fibrocor is on track to complete all IND-enabling work to support IND filing and initiation of clinical trials in 2024. Phase I of the clinical program will dose healthy volunteers with single ascending doses of FIB992 before proceeding to a multiple ascending dose study where the drug is administered for a two-week period.

Research

Research Gene Expression Drugs Development

CRISPR breakthroughs: New solutions for common diseases

Drug Discovery World

JULY 18, 2023

Since its discovery in 2012, CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) technology has revolutionised the biomedicine and cell and gene therapy fields, providing a versatile tool for precise and efficient genome editing.

DNA

DNA Genome Genomics RNA

FAIR Game: making data work harder in the race to market

Drug Discovery World

OCTOBER 17, 2022

For example, GEO, the gene expression omnibus database, has been collecting gene expression and functional genomics datasets and making them available to the public for more than 20 years. It takes the right skill set, good information, and the ability to change course as needed.

Marketing

Marketing Scientist Gene Expression Drugs

Tezepelumab granted Priority Review by U.S. FDA

The Pharma Data

JULY 8, 2021

Amgen (NASDAQ:AMGN) announced that the U.S. Food and Drug Administration (FDA) has accepted a Biologics License Application (BLA) and granted Priority Review for tezepelumab in the treatment of asthma. Tezepelumab is being developed by Amgen in collaboration with AstraZeneca. Reese, M.D., About Severe Asthma. Globally, there are approximately 2.5

Allergies

Allergies Trials In-Vivo Medicine

The use of base editing in stem-cell based therapies

Drug Discovery World

JANUARY 23, 2023

Kevin Hemphill, R&D Manager at PerkinElmer’s Horizon Discovery explores how base editing has emerged as an attractive gene editing option for researchers wanting to develop stem cell-based therapies. Adult fibroblasts were cultured in a cocktail of transcription factors to reactivate embryonic gene expression patterns 2.

Gene Editing

Gene Editing Gene Engineer DNA

Synthetic biology tools advancing and accelerating drug discovery efforts

Drug Discovery World

NOVEMBER 15, 2022

If you want to order gene-length sequences, rather than short oligos for PCR, the waiting times are around two or three weeks at least. Anita Ramanathan outlines four synthetic biology approaches that are improving and accelerating drug discovery. . This way, we can separate erroneous sequences from accurate ones.

DNA

DNA Drugs Antibody Engineer

Clinical Research Informer

Combining the Powers of Single Cell Sequencing and AI in Understanding Disease Biology and Drug Development

Gene editing: beyond the hype

Trending Sources

Using gene therapy to live longer, healthier lives

Biologics – The Next Step in Revolutionary Medication

Advances in Genetic Medicine May Be Outpacing Some Clinicians’ Understanding, But Pharmaceutical Marketers Can Do Much to Address the Problem

Cell-penetrating peptides as a delivery system for oligonucleotides

Angelman Syndrome Market: Insights Into The Recent Late-Stage Drug Failures And Novel Approaches To Treating This Rare Neurogenetic Disorder

What the Glycome Can Tell Us About Persistent HIV Infection

Gene Switch: A Novel Platform for Switching Genes On and Off

Delivering on the promise of gene editing

Fibrosis research: Advances and challenges

CRISPR breakthroughs: New solutions for common diseases

FAIR Game: making data work harder in the race to market

Tezepelumab granted Priority Review by U.S. FDA

The use of base editing in stem-cell based therapies

Synthetic biology tools advancing and accelerating drug discovery efforts

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