XTalks

JUNE 17, 2022

It blocks the activity of JAK1 and JAK2 to interfere with the JAK-STAT signaling pathway to dampen the production of inflammatory cytokines through the modulation of gene expression. Olumiant is a Janus kinase (JAK) inhibitor that was first discovered by Incyte and then licensed to Eli Lilly.

FDA Approval 97

FDA Approval Gene Expression Cosmetics Trials 97

XTalks

MARCH 22, 2021

As a leader in life sciences, diagnostics and applied chemical markets, it is looking to grow its cancer diagnostics pipeline. Both of Biotheranostics’ diagnostics are PCR-based gene expression tests. Agilent is a major provider of instruments, consumables, applications and services to laboratories worldwide.

Life Science 110

Life Science Development Marketing Gene Expression 110

XTalks

OCTOBER 8, 2024

Despite containing the same set of genes, cells are able to differentiate due to the regulatory role of microRNAs, which control gene expression in a precise manner. Ambros and Ruvkun’s work demonstrated that small RNAs could repress gene expression after mRNA was made, pointing to a previously unknown layer of genetic control.

Regulation 52

Regulation Genetics Scientist RNA 52

XTalks

MARCH 7, 2024

The company’s ResolveOME multiomic workflow provides a comprehensive multiomic analysis of breast cancer through the use of exome hybrid capture alongside a single-cell workflow for single-cell resolution of single nucleotide variants (SNVs), copy number alterations and gene expression signatures, coupled with a targeted protein panel.

Genetics 115

Genetics Hormones Genome Genomics 115

The Pharma Data

JULY 12, 2021

.” In the new study, Ghosh and colleagues replaced the first and last steps in preclinical drug discovery with two novel approaches developed within the UC San Diego Institute for Network Medicine (iNetMed), which unites several research disciplines to develop new solutions to advance life sciences and technology and enhance human health.

Drugs 52

Drugs Gene Expression Big Data Gene 52

XTalks

MAY 4, 2021

These modifications regulate gene expression without altering the sequence or structure of DNA. Related: 2020 Year in Review: COVID-19, CRISPR and Immunotherapies Define the Year for the Life Sciences. We can do this for multiple genes at the same time without any DNA damage, and in a way that can be reversed.

DNA 52

DNA Gene Gene Silencing Genome 52

XTalks

MAY 31, 2022

Tapinarof treatment in a mouse model of psoriasis resulted in the downregulation of inflammatory cytokine expression in skin tissue, which involved IL17A , IL17F , IL19 , IL22 , IL23A and IL1B gene expression. Clinical Trials of Vtama.

FDA Approval 98

FDA Approval Clinical Trials Clinical Trials Trials 98

XTalks

NOVEMBER 6, 2020

DNA vaccines designed using the platform consist of a combination of an advanced gene expression plasmid (pDNA) with gene(s) of interest, and a probiotic bacterium to deliver the vaccine directly to the gut, where it binds to intestinal epithelial cells.

Clinical Trials 75

Clinical Trials Clinical Trials Vaccination Vaccine 75

XTalks

JUNE 18, 2024

c-srRNA: A Temperature-Controllable Innovation Elixirgen Therapeutics’ c-srRNA platform offers a novel approach to controlling gene expression through temperature sensitivity. The essence of the c-srRNA platform lies in its innovative use of temperature as a regulatory mechanism.

Protein 52

Protein RNA Genetics Gene Expression 52

The Pharma Data

FEBRUARY 22, 2021

Her cryo-electron microscopy studies include analysis of nuclear peripheries and the machinery of gene expression in bacteria. Innovative solutions such as those developed by Dr. Zitnik are essential for dealing with the massive amounts of data and their complexity in medicine and life sciences. The Otto Bayer Award.

Scientist 40

Scientist Life Science Research Gene Expression 40

XTalks

DECEMBER 24, 2020

The pandemic propelled the life science and healthcare sectors onto center stage, and they rose to the occasion against the most unprecedented health challenge in recent times. While COVID-19 has undoubtedly been the biggest story in the life science industry in 2020, it was a busy and positive year in many other areas.

Life Science 111

Life Science Vaccination Vaccine Gene 111

XTalks

AUGUST 12, 2020

The importance of identifying and combining signatures across multiple realms, from gene expression to the proteome to the glycome, is important in the effective identification, classification and therapeutic targeting of disease in a more specified and personalized manner, and in contributing to our overall understanding of biological processes.

RNA 52

RNA Protein DNA In-Vivo 52

XTalks

FEBRUARY 11, 2021

Daly’s histone research proved to be pioneering, being fundamental to our understanding of DNA packaging, gene expression and epigenetics, among other areas in genetic research. She also established a scholarship fund at Queens College for African Americans in commemoration of her father in 1988.

Genetics 119

Genetics DNA Genome Genomics 119

XTalks

SEPTEMBER 21, 2020

Increasing KDM6A expression in male mice led them to be more resilient to the effects of amyloid beta plaques. The scientists also looked at public databases of gene expression studies through which they discovered a particularly active variant of KDM6A that is present in about 13 percent of women and seven percent of men around the world.

Gene 89

Gene Protein Gene Expression Scientist 89