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HDACs catalyze the removal of acetyl groups from acetylated lysine residues in histones, resulting in the modulation of geneexpression. HDACs also deacetylate non-histone proteins, such as transcription factors.
Hepatic ALT isoenzymes are elevated in gluconeogenic conditions including diabetes and suppressed by insulin at the protein level. Clinical impact of Mediterranean-enriched-protein diet on liver size, visceral fat, fat mass, and fat-free mass in patients undergoing sleeve gastrectomy. DOI: 10.1371/journal.pone.0123136. 2014;121:267-92.
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