Scienmag

MARCH 19, 2021

Credit: Thomas Gorochowski In a recent study led by the University of Bristol, scientists have shown how to simultaneously harness multiple forms of regulation in living cells to strictly control gene expression and open new avenues for improved biotechnologies.

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Medical Xpress

MARCH 13, 2023

Researchers at University of California San Diego School of Medicine and Moores Cancer Center at UC San Diego Health have identified a strong association between the product of a gene expressed in most cancers, including the most common type of head and neck cancer, and elevated levels of white blood cells that produce antibodies within tumors.

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XTalks

DECEMBER 30, 2024

Cenerimod modulates the immune response, reducing inflammation and preventing the production of harmful autoantibodies. A subgroup analysis revealed even greater improvement in patients with high interferon-1 (IFN-1) gene expression, a known indicator of disease severity, with a -2.78 in mSLEDAI-2K compared to placebo.

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Pharmaceutical Technology

JUNE 4, 2023

Innovation S-curve for the pharmaceutical industry Transcription factors for genetically modified cells is a key innovation area in the pharmaceutical industry Transcription factors are proteins which control gene expression by controlling the rate of transcription of genetic information from DNA to RNA.

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pharmaphorum

JANUARY 10, 2023

. “This agreement provides an opportunity to deliver potentially transformative gene therapy treatments to a specific population of LOPD adult patients who might otherwise be ineligible for clinical trials or treatment with Astellas’ investigational product” commented Naoki Okamura, Astellas’ chief strategy officer.

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XTalks

JUNE 17, 2022

It blocks the activity of JAK1 and JAK2 to interfere with the JAK-STAT signaling pathway to dampen the production of inflammatory cytokines through the modulation of gene expression. Olumiant is a Janus kinase (JAK) inhibitor that was first discovered by Incyte and then licensed to Eli Lilly.

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XTalks

MARCH 13, 2024

Secondly, other funded research is exploring differential gene expression regulated by DNA methylation. By identifying genes affected by DNA methylation in glaucoma, researchers hope to uncover new insights into the disease’s molecular mechanisms.

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XTalks

OCTOBER 8, 2024

Essentially, microRNAs block the expression of the gene by stopping the production of the corresponding protein from mRNA’s instructions, effectively regulating which genes are “turned on” or “off” in the cell. However, microRNAs can bind to this mRNA, preventing it from functioning.

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Camargo

JULY 8, 2021

The UCLA researchers measured monoamine oxidase A (MAOA) gene expression in tumors from cancer patients and found that high MAOA expression was associated with shorter survival times and turned to a mouse model to investigate these observations with promising results.

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Roots Analysis

AUGUST 31, 2023

The two types of gene regulation have been discussed below: Positive Gene Regulation: Activator is a protein molecule that helps to initiate a positive gene regulation. When activator binds to the operon, it either speeds up or permits gene expression.

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pharmaphorum

JANUARY 13, 2022

In 2020, it joined forces with UK start-up MiNA Therapeutics to develop small activating RNAs (saRNAs) that can indirectly affect transcription factors and dial the production of disease-associated proteins up or down. It’s not the big pharma’s first foray into the transcription factor area.

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XTalks

NOVEMBER 6, 2020

DNA vaccines designed using the platform consist of a combination of an advanced gene expression plasmid (pDNA) with gene(s) of interest, and a probiotic bacterium to deliver the vaccine directly to the gut, where it binds to intestinal epithelial cells.

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The Pharma Data

JULY 11, 2021

Eli Lilly and Company (NYSE: LLY) announced new Phase 2 data showing that gene expression changes induced by mirikizumab in patients with ulcerative colitis (UC) over a 12-week induction treatment were maintained for up to one year. For methodology, see the “About the Studies” section below.

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Roots Analysis

AUGUST 12, 2024

According to the World Health Organization, there are over 40,000 in vitro diagnostics products available in the market. This vast array of products highlights the critical role of diagnostics in healthcare. Such test can be used for gene expression profiling, genotyping and detecting chromosomal abnormalities.

Genetics 40

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The Pharma Data

MARCH 3, 2022

CHGA levels were also easily measured directly in serum using a simple ELISA assay after a blood draw, and lower levels in verapamil-treated subjects correlated with better endogenous insulin production as measured by mixed-meal-stimulated C-peptide, a standard test of Type 1 diabetes progression. ” Source link: [link].

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The Pharma Data

OCTOBER 15, 2020

Specifically, that entails improving manufacturing to control variables and thus ensure product consistency, and maturing the regulatory environment to improve predictability. For our dry AMD product, we can manufacture 5 billion retinal cells in a three liter bioreactor. We’re beyond that,” Culley said.

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The Pharma Data

JANUARY 17, 2021

The primary endpoint of this trial is to evaluate patients for complete histological clearance of the tumor cells within the treated BCC lesion with secondary endpoints, evaluating subjects for investigational product treatment related adverse events, as well as serious adverse events, and cutaneous skin reactions. Chief Medical Officer.

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Roots Analysis

JANUARY 14, 2024

Overview of Biologics Biologics refer to medicinal / therapeutic products that are either manufactured using living organisms or semi-synthesized from biological sources. This can be attributed to the fact that the production of biopharmaceuticals requires living expression systems.

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The Pharma Data

NOVEMBER 9, 2020

Further, preclinical results do not guarantee safe and effective performance of product candidates in humans. Further, preclinical results do not guarantee safe and effective performance of product candidates in humans. Amgen develops product candidates internally and through licensing collaborations, partnerships and joint ventures.

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The Pharma Data

SEPTEMBER 2, 2021

The settlement of circulating tumor cells in a distant organ is promoted by factors whose production is induced by the primary tumor itself. ” With a particular focus on the lung, the researchers performed global gene expression analyses of the metastatic niche.

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The Pharma Data

JULY 11, 2021

On the other hand, they can inhibit specific enzymes that regulate the accessibility to the genetic material and thus the gene expression in the T cells. “When short-chain fatty acids reprogram CD8 T cells, one of the results is increased production of pro-inflammatory and cytotoxic molecules,” Luu explains.

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Delveinsight

JANUARY 18, 2021

Of all the Angelman syndrome pipeline therapies , the most touted treatment was Gaboxadol ( OV101 or THIP ), a product of Ovid Therapeutics. For instance, GTX-102 , an antisense therapy silencing the gene expression by binding to the RNA molecule behind the regulation of its expression, has also secured USFDA Fast Track Designation.

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Roots Analysis

OCTOBER 22, 2023

Coding RNAs include messenger RNA (mRNA) and short interfering RNA (siRNA), which encode proteins and silence gene expression, respectively. ASOs are short single-stranded nucleotides that bind to specific messenger RNAs and prevent the production of a particular protein.

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Roots Analysis

AUGUST 31, 2023

At present, extensive studies are being conducted to understand the interaction between nutrients and gene expression at the molecular level, to determine the effect of a specific nutrient and dietary regime on human health. Similarly, people suffering from lactose intolerance must avoid milk products.

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The Pharma Data

DECEMBER 14, 2020

Combining DetermaRx with our products for genetic testing and MRD detection (currently under R&D), we can provide a comprehensive testing strategy for oncologists to ultimately benefit Chinese early-stage NSCLC patients by improving their survival and quality of life.

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The Pharma Data

JANUARY 19, 2021

Fulcrum’s proprietary product engine identifies drug targets which can modulate gene expression to treat the known root cause of gene mis-expression.

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The Pharma Data

DECEMBER 27, 2020

STP705 is a small interfering RNA (siRNA) therapy that leverages a dual-targeted inhibitory property and polypeptide nanoparticle (PNP)-enhanced delivery to knock down both TGF-beta1 and COX-2 gene expression. GA Depot is a long-acting injection of the approved Glatiramer Acetate products (Copaxone and its generic formulations).

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Roots Analysis

NOVEMBER 3, 2023

This enzyme plays a crucial role in the production of nicotinamide adenine dinucleotide (NAD + ), a molecule that is essential for cellular metabolism. NAMPT inhibitors work by blocking the activity of NAMPT, which in turn reduces the production of NAD +.

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XTalks

DECEMBER 24, 2020

From rare disease drug approvals to treatments involving immunotherapies and gene therapies and awarding of a Nobel Prize to the inventors of the gene-editing tool CRISPR, 2020 was a year of great activity and productivity despite the backdrop of the pandemic.

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XTalks

SEPTEMBER 21, 2020

A female’s second X chromosome is typically silenced (so that females don’t get an overdose of X chromosome genes) through X-linked inactivation, a process where the chromosome is coated with an outer layer of non-coding RNA. One of these doubly active genes is KDM6A. KDM6A Variant.

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The Pharma Data

MAY 15, 2021

Product Name: My Hemochromatosis cb vsl | Blue Heron Health News. If within the first 60 days of receipt you are not satisfied with Wake Up Lean , you can request a refund by sending an email to the address given inside the product and we will immediately refund your entire purchase price, with no questions asked.

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The Pharma Data

MAY 13, 2021

Product Name: Let's Quit Sugar With Audiobook – Let's Quit Sugar. If within the first 60 days of receipt you are not satisfied with Wake Up Lean , you can request a refund by sending an email to the address given inside the product and we will immediately refund your entire purchase price, with no questions asked.

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The Pharma Data

AUGUST 3, 2021

HDACs catalyze the removal of acetyl groups from acetylated lysine residues in histones, resulting in the modulation of gene expression. Istodax ® (romidepsin) for injection is an epigenetic therapy and a member of a class of cancer drugs known as histone deacetylase (HDAC) inhibitors.

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