pharmaphorum

NOVEMBER 12, 2021

By tying these to underlying disease-protein-pathway relationships, the AI was also able to suggest a list of drugs – many of them untested in COVID-19 – that could be candidates for treatments of these complications.

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Doctors Doctor Drugs Gene Expression 135

BioTech 365

DECEMBER 4, 2020

Source : Biology Textbooks Wrong? New Research Reveals the Secret Behind a Key Cellular Process (scitechdaily.com) New research has identified and described a cellular process that, despite what textbooks say, has remained elusive to scientists until now — precisely how … Continue reading →

Gene Expression 52

Gene Expression Protein Research Gene 52

BioTech 365

NOVEMBER 25, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Study highlights role of disordered protein interactions in gene expression.A

Gene Expression 40

Gene Expression Protein Gene Medicine 40

Pharmaceutical Technology

JANUARY 24, 2023

The investigational adeno-associated virus (AAV) gene therapy candidate NGN-401 is claimed to be the first to deliver the full-length human MECP2 gene using the company’s Expression Attenuation via Construct Tuning (EXACT) gene regulation technology.

Gene Therapy 208

Gene Therapy Gene Gene Expression Regulation 208

Scienmag

FEBRUARY 18, 2021

Mount Sinai researchers have discovered that Polycomb complexes, groups of proteins that maintain gene expression patterns, are essential for proper skin development, according to a paper published in Genes & Development on February 18.

Gene Expression 72

Gene Expression Development Research Gene 72

Pharmaceutical Technology

JUNE 13, 2023

Ziftomenib targets the menin-KMT2a protein-protein interaction that may occur in patients with KMT2ar or NPM1m genetic alterations. The aberrant protein complex is essential for regulating leukaemia-promoting gene expression. Thus, targeting menin may be an effective strategy for patients with high unmet needs.

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Gene Expression Protein Sales Genetics 130

Medical Xpress

NOVEMBER 22, 2022

A form of blood cancer known as mantle cell lymphoma is critically dependent on a protein that coordinates gene expression, such that blocking its activity with an experimental drug dramatically slows the growth of this lymphoma in preclinical tests, according to a study from Weill Cornell Medicine researchers.

Gene Expression 64

Gene Expression Protein Gene Medicine 64

XTalks

AUGUST 5, 2020

The detailed complexity of these processes can be captured by creating models that combine correlates of gene and protein expression, providing insight into the molecular composition of tissues. Visium Spatial Gene Expression Solution. Feature barcoding using gel beads. Single Cell Data Analysis.

Gene Expression 112

Gene Expression Development RNA Drugs 112

Scienmag

MAY 27, 2021

Capturing how RNA polymerase enzymes kick off transcription On scales too small for our eyes to see, the business of life happens through the making of proteins, which impart to our cells both structure and function.

Gene Expression 41

Gene Expression RNA DNA Protein 41

Scienmag

NOVEMBER 26, 2020

For the first time, researchers describe how Rho protein really stops gene expression COLUMBUS, Ohio – New research has identified and described a cellular process that, despite what textbooks say, has remained elusive to scientists until now – precisely how the copying of genetic material that, once started, is properly turned off.

Gene Expression 54

Gene Expression Genetics Protein Gene 54

Pharmaceutical Technology

AUGUST 11, 2022

Alnylam has reported that it aims to develop a therapy that targets the INHBE gene and reduces the overall risk of T2D and coronary heart disease for at-risk patients. Targeting gene expression that results in increased abdominal fat and leads to obesity is a key factor for the reduction of T2D and wider metabolic syndrome.

Gene 130

Gene Biobanking Gene Expression In-Vitro 130

Scienmag

APRIL 5, 2021

Study shows that tumor-suppressor protein p53 brings speckles and DNA together to boost gene expression PHILADELPHIA – A team led by scientists at the Perelman School of Medicine at the University of Pennsylvania has illuminated the functions of mysterious structures in cells called “nuclear speckles,” showing that they can work in (..)

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Gene Gene Expression DNA Protein 42

BioTech 365

AUGUST 25, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Enabling cells to talk to computers.Genetically encoded reporter proteins have been a mainstay of biotechnology research, allowing scientists to track gene expression, understand intracellular processes and debug … Continue (..)

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Gene Expression Protein Gene Scientist 40

pharmaphorum

JANUARY 13, 2022

AstraZeneca has expanded its efforts to develop new therapies targeting transcription factors – proteins that regulate processes in the cell that have become a hot topic for drug discovery in cancer and other diseases.

Protein 59

Protein Gene Expression Gene Regulation 59

XTalks

NOVEMBER 6, 2020

Symvivo’s bacTRL Gene Therapy Platform is designed and optimized to address limitations associated with typical vaccines, including the inability to accommodate large or multiple genes, lack of specificity to targeted tissue and poor control over immune response, says the company.

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Clinical Trials Clinical Trials Vaccination Vaccine 75

The Pharma Data

FEBRUARY 24, 2022

UNC researchers now show that these two factors can directly associate with one another, modulating cancer-cell-specific programs of gene expression. ” They found that EZH2 possesses two different binding patterns on chromatin in acute leukemia cells, eliciting two distinct gene-regulatory programs (Figure 1).

Scientist 52

Scientist Gene Expression Gene Genome 52

XTalks

MARCH 7, 2024

The company’s ResolveOME multiomic workflow provides a comprehensive multiomic analysis of breast cancer through the use of exome hybrid capture alongside a single-cell workflow for single-cell resolution of single nucleotide variants (SNVs), copy number alterations and gene expression signatures, coupled with a targeted protein panel.

Genetics 115

Genetics Hormones Genome Genomics 115

The Pharma Data

MARCH 3, 2022

To examine changes in circulating proteins in response to verapamil treatment, the researchers used liquid chromatography-tandem mass spectrometry of blood serum samples from subjects diagnosed with Type 1 diabetes within three months of diagnosis and at one year of follow-up.

Insulin 52

Insulin Gene Expression Gene Protein 52

pharmaphorum

MARCH 10, 2021

Vector insertion in the AML cells from this patient took place in the VAMP4 gene, or vesicle-associated membrane protein 4 – but the gene itself has no known role in the development of AML or with any cellular process related to cancer. Shares in bluebird ticked up following the announcement.

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Gene Therapy Gene Trials Gene Expression 59

XTalks

MARCH 13, 2024

Firstly, investigations into the lipidome in pseudoexfoliation glaucoma aim to understand how lipid metabolism influences the development or progression of this specific type of glaucoma, characterized by abnormal protein deposits in the eye.

Gene Therapy 111

Gene Therapy Gene Life Science DNA 111

pharmaphorum

NOVEMBER 22, 2022

Beta catenin meanwhile is a signalling protein in the Wnt pathway – in particular a downstream transcription factor (TCF) implicated in a range of solid tumour types including colorectal, liver, breast, prostate, uterus and lung cancers.

Gene Expression 52

Gene Expression Packaging Packaging Medicine 52

Roots Analysis

AUGUST 12, 2024

Hybridization Tests – These tests utilize complementary DNA or RNA probes to detect and quantify specific genetic targets, enabling the identification of pathogens, genetic variations, and gene expression patterns. Such test can be used for gene expression profiling, genotyping and detecting chromosomal abnormalities.

Genetics 40

Genetics Gene Expression RNA DNA 40

Delveinsight

JANUARY 18, 2021

However, DelveInsight’s Angelman syndrome market analysis report estimates that several approaches focused primarily on the Gene Therapies, Topoisomerase Inhibitors, Cannabidiol, Protein Phosphatase 2A inhibitor, among others are under development to find a cure for the Angelman syndrome.

Marketing 52

Marketing Gene Drugs Protein 52

The Pharma Data

SEPTEMBER 2, 2021

” With a particular focus on the lung, the researchers performed global gene expression analyses of the metastatic niche. They discovered that in the presence of a primary tumor, the endothelial cells lining the interior of blood vessels produced the protein LRG1 (leucine-rich alpha-2-glycoprotein 1) in large quantities.

Gene Expression 52

Gene Expression Scientist Antibody Research 52

The Pharma Data

JUNE 14, 2023

Abell Chair in Molecular and Cellular Biology – and Pengbo Cao, a postdoctoral researcher in Whiteley’s lab, discovered a gene that drives the switch. By measuring bacterial gene expression in human tissue samples, the researchers identified a biomarker for the transition.

RNA 40

RNA Regulation Scientist Bacteria 40

The Pharma Data

OCTOBER 19, 2020

ANGLE’s proven patent protected platforms include a circulating tumor cell (CTC) harvesting technology and a downstream analysis system for cost effective, highly multiplexed analysis of nucleic acids and proteins. The system is epitope independent and can capture all types of CTCs as well as CTC clusters in a viable form (alive).

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Protein Gene Expression RNA DNA 40

Roots Analysis

AUGUST 31, 2023

At present, extensive studies are being conducted to understand the interaction between nutrients and gene expression at the molecular level, to determine the effect of a specific nutrient and dietary regime on human health. In part, the success of the Human Genome Project has also paved a path for the novel concept of nutrigenomics.

Genome 40

Genome Genomics Genetics Gene 40

Camargo

JULY 27, 2021

Gene Expression Considerations. However, characterizing PK for such therapies involves not only the initial genetic material, but also products of gene expression without the inherent original mutation being treated, such as proteins.

Gene Therapy 238

Gene Therapy Gene Gene Editing Genetics 238

The Pharma Data

MARCH 7, 2022

By combining CRISPR technology with a protein designed with artificial intelligence (AI), it is possible to awaken individual dormant genes by disabling the chemical “off switches” that silence them. These methyl groups must be refreshed so if PRC2 is blocked the genes it has silenced. it can be reawakened.

Protein 52

Protein Gene Genome Genomics 52

Pharmaceutical Technology

JUNE 4, 2023

Innovation S-curve for the pharmaceutical industry Transcription factors for genetically modified cells is a key innovation area in the pharmaceutical industry Transcription factors are proteins which control gene expression by controlling the rate of transcription of genetic information from DNA to RNA.

Genetics 130

Genetics Gene Expression DNA Antibody 130

Scienmag

SEPTEMBER 10, 2020

Findings suggest one factor that may contribute to disparities in COVID-19 infection New York – In a study published in JAMA today, Mount Sinai researchers report findings that shed some light on the disproportionate impact of COVID-19 on Blacks, who have experienced rates of infection and death that are much greater, in some areas twice […]. (..)

Gene Expression 40

Gene Expression Protein Gene Research 40

XTalks

MAY 4, 2021

These modifications regulate gene expression without changing the sequence or structure of DNA. The CRISPR gene editing system consists of the Cas9 enzyme, which serves as molecular scissors to cleave double-stranded DNA, and a guide RNA template targeted to a specific genomic sequence, which allows for precise editing.

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DNA Gene Gene Silencing Genome 98

pharmaphorum

JANUARY 29, 2021

ZFPs can be engineered to make zinc finger nucleases, or ZFNs, which are proteins that can be used to edit genomes by knocking select genes in or out to specifically modify DNA sequences. Zinc fingers are the most common control gene in the body,” Macrae explains.

Gene Editing 145

Gene Editing Gene Gene Therapy In-Vivo 145

Roots Analysis

OCTOBER 22, 2023

Coding RNAs include messenger RNA (mRNA) and short interfering RNA (siRNA), which encode proteins and silence gene expression, respectively. ASOs are short single-stranded nucleotides that bind to specific messenger RNAs and prevent the production of a particular protein.

RNA 40

RNA Protein Genetics Gene Expression 40

XTalks

OCTOBER 8, 2024

To activate these instructions, cells create a copy called messenger RNA (mRNA), which exits the nucleus and directs the cell’s machinery to produce a specific protein. Despite containing the same set of genes, cells are able to differentiate due to the regulatory role of microRNAs, which control gene expression in a precise manner.

Regulation 52

Regulation Genetics Scientist RNA 52

Roots Analysis

AUGUST 31, 2023

Further, the expression of any gene is dependent on the rate at which it is transcribed into mRNA and translated into proteins. There are various regulatory proteins or transcription factors that are responsible for affecting the transcription rate.

Gene 40

Gene Gene Therapy Gene Expression Regulation 40

BioTech 365

OCTOBER 14, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Protein that manipulates gene expression inside the cell nucleus could inspire new RSV drugs, vaccines.Protein that manipulates gene expression inside the cell nucleus could inspire new RSV … Continue reading →

Gene Expression 40

Gene Expression Protein Gene Drugs 40