The Pharma Data

FEBRUARY 24, 2022

UNC researchers now show that these two factors can directly associate with one another, modulating cancer-cell-specific programs of gene expression. ” They found that EZH2 possesses two different binding patterns on chromatin in acute leukemia cells, eliciting two distinct gene-regulatory programs (Figure 1).

Scientist 52

Scientist Gene Expression Gene Genome 52

Scienmag

APRIL 5, 2021

Study shows that tumor-suppressor protein p53 brings speckles and DNA together to boost gene expression PHILADELPHIA – A team led by scientists at the Perelman School of Medicine at the University of Pennsylvania has illuminated the functions of mysterious structures in cells called “nuclear speckles,” showing that they can work in (..)

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Gene Gene Expression DNA Protein 42

The Pharma Data

JUNE 14, 2023

Scientists discover small RNA that regulates bacterial infection People with weakened immune systems are at constant risk of infection. Abell Chair in Molecular and Cellular Biology – and Pengbo Cao, a postdoctoral researcher in Whiteley’s lab, discovered a gene that drives the switch.

RNA 40

RNA Regulation Scientist Bacteria 40

XTalks

MAY 4, 2021

These modifications regulate gene expression without changing the sequence or structure of DNA. The CRISPR gene editing system consists of the Cas9 enzyme, which serves as molecular scissors to cleave double-stranded DNA, and a guide RNA template targeted to a specific genomic sequence, which allows for precise editing.

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DNA Gene Gene Silencing Genome 98

pharmaphorum

MARCH 10, 2021

bluebird bio is to ask regulators to restart clinical studies of its LentiGlobin for sickle cell disease, after an investigation concluded that a case of acute myeloid leukaemia (AML) was “very unlikely” to be caused by the gene therapy. Shares in bluebird ticked up following the announcement.

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Gene Therapy Gene Trials Gene Expression 55

The Pharma Data

SEPTEMBER 2, 2021

Scientists from the German Cancer Research Center (DKFZ) and the Medical Faculty Mannheim, Heidelberg University, have now identified a new growth factor produced by blood vessels that enables tumor cells to metastatically colonize organs. In fact, scientists were able to slow the metastatic growth of breast and lung tumors in this way.

Gene Expression 52

Gene Expression Scientist Antibody Research 52

XTalks

MAY 4, 2021

These modifications regulate gene expression without altering the sequence or structure of DNA. The CRISPR gene editing system consists of the Cas9 enzyme, which serves as molecular scissors to cleave double-stranded DNA, and a guide RNA template targeted to a specific genomic sequence, which allows for precise editing.

DNA 52

DNA Gene Gene Silencing Genome 52

Roots Analysis

AUGUST 31, 2023

At present, extensive studies are being conducted to understand the interaction between nutrients and gene expression at the molecular level, to determine the effect of a specific nutrient and dietary regime on human health. In part, the success of the Human Genome Project has also paved a path for the novel concept of nutrigenomics.

Genome 40

Genome Genomics Genetics Gene 40

XTalks

FEBRUARY 11, 2021

Much of the fundamental groundwork for genetics and genomic research was laid in the 20 th century, with significant contributions from women scientists, some of whom worked during times when acceptance of female researchers was not widespread. Martha Chase: For the Books. Martha Chase. The marriage ended in divorce after a few short years.

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Genetics DNA Genome Genomics 119

XTalks

SEPTEMBER 21, 2020

UCSF scientists found that having an additional copy of the sex chromosome gives women two “doses” of a gene found only on that chromosome. The gene, called KDM6A , is a histone demethylase that is believed to function as a tumor suppressor. The Active Gene. One of these doubly active genes is KDM6A. KDM6A Variant.

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Gene Protein Gene Expression Scientist 73

XTalks

DECEMBER 24, 2020

After being identified in December 2019 in Wuhan, Hubei in China, medical officials and scientists got to work to isolate and identify the novel virus that they observed to be causing a new respiratory illness. Most antibody drugs and vaccines have been developed to target parts of the spike protein.

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Life Science Vaccination Vaccine Gene 110