BioTech 365

OCTOBER 6, 2020

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: The plant hormone auxin may promote disease by regulating virulence gene expression.Scientists have long known that the plant hormone auxin controls many aspects of plant growth, development, … Continue reading →

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Hormones Gene Expression Regulation Gene 40

XTalks

OCTOBER 8, 2024

The 2024 Nobel Prize in Physiology or Medicine has been awarded to American scientists Victor Ambros and Gary Ruvkun for their groundbreaking discovery of microRNA (or miRNA) and its role in post-transcriptional gene regulation. This control plays a critical role in development and cellular function.

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Regulation Genetics Scientist RNA 52

XTalks

FEBRUARY 21, 2025

Related: Obesity-Focused Metsera Launches IPO Amid Much Anticipation Aardvarks approach centers on developing novel, small-molecule drugs that harness the bodys natural hunger-regulating mechanisms.

Genetics 59

Genetics Hormones Gene Expression Gene 59

XTalks

DECEMBER 30, 2024

It regulates immune cell trafficking, preventing harmful immune cells from accumulating in tissues while reducing pro-inflammatory cytokines and autoantibodies. A subgroup analysis revealed even greater improvement in patients with high interferon-1 (IFN-1) gene expression, a known indicator of disease severity, with a -2.78

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Immune Response Gene Expression Drugs Trials 52

Pharmaceutical Technology

JUNE 13, 2023

The aberrant protein complex is essential for regulating leukaemia-promoting gene expression. Ziftomenib targets the menin-KMT2a protein-protein interaction that may occur in patients with KMT2ar or NPM1m genetic alterations. Thus, targeting menin may be an effective strategy for patients with high unmet needs.

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Gene Expression Protein Sales Genetics 130

The Pharma Data

JULY 11, 2021

Eli Lilly and Company (NYSE: LLY) announced new Phase 2 data showing that gene expression changes induced by mirikizumab in patients with ulcerative colitis (UC) over a 12-week induction treatment were maintained for up to one year. For methodology, see the “About the Studies” section below.

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Regulation Gene Gene Expression Packaging 52

Pharmaceutical Technology

JUNE 4, 2023

Innovation S-curve for the pharmaceutical industry Transcription factors for genetically modified cells is a key innovation area in the pharmaceutical industry Transcription factors are proteins which control gene expression by controlling the rate of transcription of genetic information from DNA to RNA.

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Genetics Gene Expression DNA Antibody 130

Delveinsight

JULY 24, 2021

Another therapy by the same company named GTX-102 is also an antisense therapy; however, it silences gene expression by binding to the RNA molecule that regulates its expression. It is designed to target and inhibit the molecule that silences the paternal copy of the gene, called UBE3A antisense transcript (UBE3A-AS).

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Gene Therapy Gene Gene Expression RNA 96

The Pharma Data

JUNE 14, 2023

Scientists discover small RNA that regulates bacterial infection People with weakened immune systems are at constant risk of infection. Abell Chair in Molecular and Cellular Biology – and Pengbo Cao, a postdoctoral researcher in Whiteley’s lab, discovered a gene that drives the switch.

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RNA Regulation Scientist Bacteria 40

Scienmag

JUNE 14, 2021

The study, “Transcriptomics identifies STAT3 as a key regulator of hippocampal gene expression and anhedonia during withdrawal from chronic alcohol exposure,” is published in the journal Translational Psychiatry by researchers […].

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Gene Expression Research Gene Regulation 41

pharmaphorum

JANUARY 29, 2021

California-based Sangamo Therapeutics is one such company that believes in the powerful potential of in vivo genome editing and regulation, together known as genome engineering, and has built up a sizable preclinical pipeline of genome regulation treatments for diseases such as Huntington’s disease and Amyotrophic lateral sclerosis (ALS).

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Gene Editing Gene Gene Therapy In-Vivo 145

Scienmag

JANUARY 11, 2021

These biomarkers are epigenetic, meaning they involve changes to molecular factors that regulate genome activity such as gene expression independent of DNA sequence, and can be passed down to future generations. In a […].

Gene Expression 41

Gene Expression DNA Genomics Genome 41

XTalks

MAY 4, 2021

These modifications regulate gene expression without changing the sequence or structure of DNA. Now we have a simple tool that can silence the vast majority of genes,” said Jonathan Weissman, PhD, Whitehead Institute member, co-senior author of the new paper and a former UCSF faculty member in a statement from UCSF. “We

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DNA Gene Gene Silencing Genomics 98

Roots Analysis

AUGUST 31, 2023

Type of Gene Regulation Based on the type of transcription factor ( activators / repressors ), gene regulation has been categorized into positive and negative gene regulation. When activator binds to the operon, it either speeds up or permits gene expression.

Gene 40

Gene Gene Therapy Gene Expression Regulation 40

pharmaphorum

MARCH 10, 2021

bluebird bio is to ask regulators to restart clinical studies of its LentiGlobin for sickle cell disease, after an investigation concluded that a case of acute myeloid leukaemia (AML) was “very unlikely” to be caused by the gene therapy. Shares in bluebird ticked up following the announcement.

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Gene Therapy Gene Trials Gene Expression 59

pharmaphorum

JANUARY 13, 2022

AstraZeneca has expanded its efforts to develop new therapies targeting transcription factors – proteins that regulate processes in the cell that have become a hot topic for drug discovery in cancer and other diseases.

Protein 59

Protein Gene Expression Gene Regulation 59

pharmaphorum

OCTOBER 19, 2022

The dark genome – a loose term that covers non-coding regions of the genome that are capable of regulating the expression of genes, previously rather inaccurately referred to as junk DNA – is increasingly being explored by biopharma companies for new drug targets.

Genomics 59

Genomics Genome Gene Gene Expression 59

pharmaphorum

JUNE 27, 2022

The safety of Astellas’ gene therapy portfolio has been thrust into the spotlight once again, after the FDA placed a clinical hold on a trial of its Pompe disease candidate AT845. The delivery vector – an AAV8 capsid – is designed to allow gene expression directly in target tissues like skeletal muscle.

Gene Therapy 52

Gene Therapy Gene Gene Expression Trials 52

XTalks

MARCH 13, 2024

Secondly, other funded research is exploring differential gene expression regulated by DNA methylation. By identifying genes affected by DNA methylation in glaucoma, researchers hope to uncover new insights into the disease’s molecular mechanisms.

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Gene Therapy Gene Life Science DNA 111

pharmaphorum

NOVEMBER 22, 2022

TCFs – which control gene expression and can regulate important cellular processes, including cell growth and survival – have traditionally been held to fall into the undruggable category, with fewer than 1% of them successfully targeted for therapeutics.

Gene Expression 52

Gene Expression Packaging Packaging Medicine 52

pharmaphorum

FEBRUARY 9, 2021

InteRNA is focusing on the development of gene-silencing drugs based on microRNA, naturally occurring, non-coding strands of RNA that are thought to regulate gene expression in cells.

Trials 59

Trials Gene Silencing RNA Gene Expression 59

The Pharma Data

MARCH 3, 2022

In 2018, Shalev and colleagues reported the benefits of verapamil in a one-year clinical study of Type 1 diabetes patients, finding that regular oral administration of verapamil enabled patients to produce higher levels of their own insulin, thus limiting their need for injected insulin to regulate blood sugar levels.

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Insulin Gene Expression Gene Protein 52

The Pharma Data

JULY 11, 2021

On the one hand, they can boost the metabolism of T cells by inducing central regulators of energy metabolism. On the other hand, they can inhibit specific enzymes that regulate the accessibility to the genetic material and thus the gene expression in the T cells. In doing so, they induce epigenetic changes.

Bacteria 52

Bacteria Genetics Scientist Regulation 52

XTalks

MAY 4, 2021

These modifications regulate gene expression without altering the sequence or structure of DNA. Now we have a simple tool that can silence the vast majority of genes,” said Jonathan Weissman, PhD, Whitehead Institute member, co-senior author of the new paper and a former UCSF faculty member in a statement from UCSF. “We

DNA 52

DNA Gene Gene Silencing Genomics 52

The Pharma Data

SEPTEMBER 2, 2021

” With a particular focus on the lung, the researchers performed global gene expression analyses of the metastatic niche.

Gene Expression 52

Gene Expression Scientist Antibody Research 52

The Pharma Data

MARCH 7, 2022

The new technique controls gene activity without altering the DNA sequence of the genome by targeting chemical modifications that help package genes in our chromosomes and regulate their activity. The chemical modifications that regulate gene activity are called epigenetic markers.

Protein 52

Protein Gene Genomics Genome 52

Delveinsight

JANUARY 18, 2021

For instance, GTX-102 , an antisense therapy silencing the gene expression by binding to the RNA molecule behind the regulation of its expression, has also secured USFDA Fast Track Designation. Although, it can be relieving that other players turned to different approaches for finding a cure for Angelman syndrome.

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Marketing Gene Drugs Protein 52

The Pharma Data

OCTOBER 15, 2020

Manual manipulation affects gene expression,” he pointed out, so minimizing that, as well as the vast quantities of plastics typically required, results in a more controlled process and a more consistent product. The advantage is that the cells exist in a very homogenous space and are 99% pure.”.

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Manufacturing Gene Therapy Gene Gene Expression 52

Roots Analysis

OCTOBER 22, 2023

Coding RNAs include messenger RNA (mRNA) and short interfering RNA (siRNA), which encode proteins and silence gene expression, respectively. RNA interference (RNAi) Therapeutics : Fundamentally, RNAi is a natural process of post-transcriptional gene silencing, involving short strands of nucleic acids.

RNA 40

RNA Protein Genetics Gene Expression 40

XTalks

AUGUST 12, 2020

Unique and diverse patterns of cell surface protein glycosylation (the addition of sugar molecules to proteins) make up specific glycoimmune profiles that have key functional roles in regulating cellular processes and immune functions.

RNA 52

RNA Protein DNA In-Vivo 52

Roots Analysis

JANUARY 14, 2024

Like all drugs, biologics are regulated by the FDA. Usually, the desired gene, such as human insulin gene, when inserted into the plasmid of the host cell uses transcriptional and translational machinery of the host to express itself. They are different from small molecules in terms of their size and complexity.

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Contract Manufacturing Protein Manufacturing Production 40

The Pharma Data

NOVEMBER 9, 2020

Furthermore, Amgen’s research, testing, pricing, marketing and other operations are subject to extensive regulation by domestic and foreign government regulatory authorities. Measures of gene expression in sputum cells can identify TH2-high and TH2-low subtypes of asthma. EMJ Allergy Immunol. 2018; 3: 60-9. 15 Fahy JV.

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Trials Production Sales Manufacturing 52

Scienmag

DECEMBER 1, 2021

BOSTON – An important player in the healthy development of female embryos turns out also to play a key role in regulating the behavior of chromosome loops and gene expression in both sexes, according to a new study by researchers at Massachusetts General Hospital (MGH).

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Gene Expression Gene RNA Research 61

XTalks

DECEMBER 24, 2020

BioNTech/Pfizer’s vaccine became the world’s first approved COVID-19 vaccine, with UK regulators becoming the first to authorize it for emergency use, followed by Health Canada, which fully approved it. Among these, single-cell RNA sequencing (scRNA-seq) is particularly useful for analyzing the transcriptome with respect to gene expression.

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Life Science Vaccination Vaccine Gene 111

The Pharma Data

MAY 15, 2021

It’s because certain genes act one way on some people… and another way on other people. Putting this in medical jargon, the gene ‘expresses’ one way with Bob, for example, and a completely different way with Mary. How a gene expresses – that is, how the gene affects you – goes on to determine whether you get ill or not.

Bacteria 52

Bacteria Gene Gene Therapy Gene Expression 52

The Pharma Data

MAY 13, 2021

The trans-fat ban–food regulation and long-term health. Regulation of glucose metabolism from a liver-centric perspective. Adipose tissue regulates insulin sensitivity: role of adipogenesis, de novo lipogenesis and novel lipids. The role of ghrelin in weight-regulation disorders: implications in clinical practice.

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Insulin Production Hormones Medicine 52