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Chroma Medicine's launch is the latest step in a decadeslong quest by drugmakers to capitalize on research into epigenetics, a way of controlling geneexpression without altering DNA.
Jude Children’s Research Hospital scientists have developed a highly efficient method to address a major challenge in biology–identifying the genetic ‘switches’ that regulate geneexpression. Jude Children’s Research Hospital St. Credit: St.
In the last three years alone, there have been over 633,000 patents filed and granted in the pharmaceutical industry, according to GlobalData’s report on Innovation in Pharmaceuticals: IgG geneexpressing animal models. Regeneron Pharmaceuticals is the leading patent filer in IgG geneexpressing animal models.
The authors of the study say their research is the first to link COVID-19 to molecular signatures of brain aging. “We observed that geneexpression in the brain tissue of patients who died […].
US researchers examined geneexpression in more than a million brain cells collected post-mortem from 191 donors. Those with schizophrenia and older adults were found to have a comparitively reduced expression of specific genes in both […]
New research from the Department of Biomedical Informatics (DBMI) at the University of Colorado School of Medicine has identified 45 genes whose geneexpression is associated with body mass index (BMI), many of which have not been previously explored in obesity research, after the researchers conducted a study using a multiethnic cohort.
Researchers at Baylor College of Medicine, Yale University and other institutions have identified previously unrecognized changes in geneexpression and cellular interactions in distinct cell populations in chronic obstructive pulmonary disease (COPD).
A team led by researchers at Baylor College of Medicine and the Czech Academy of Sciences has uncovered a new piece of the puzzle of how geneexpression is orchestrated. Published in the journal Science, the findings reveal a novel mechanism that coordinates the assembly of components inside cells that control geneexpression.
The type and direction of the force on a cell alters geneexpression by stretching different regions of DNA, researchers at University of […]. . — Tissues and cells in the human body are subjected to a constant push and pull – strained by other cells, blood pressure and fluid flow, to name a few.
CHOP researchers find small changes in RNA due to RNA editing could have a large impact on geneexpression and phenotype Philadelphia, March 9, 2021–Combining computational mining of big data with experimental testing in the lab, researchers at Children’s Hospital of Philadelphia (CHOP) have identified RNA editing events that influence (..)
Study marks the first time this complex has been visualized for human cells Credit: Northwestern University For the first time ever, a Northwestern University-led research team has peered inside a human cell to view a multi-subunit machine responsible for regulating geneexpression.
The research reveals new insights into how memories are formed and stored in the brain and could provide scientists with new information about diseases such […].
But they are also involved in regulating the genesexpressed within—and the signaling between—cells. When we consume fats (also called lipids) in our diet, they can be metabolized or stored to provide energy for the body.
A joint study by two groups of researchers at Peking University revealed for the first time the “pan-cancer single-cell landscape of tumor-infiltrating T cells”. Combining geneexpression profiles and T cell receptor sequences, it investigated the heterogeneity and dynamics […].
Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: MIT and UCSF researchers create CRISPR ‘on-off switch’ that controls geneexpression without changing DNA.MIT and UCSF researchers create CRISPR ‘on-off switch’ that controls geneexpression without … Continue reading → (..)
Researchers at University of California San Diego School of Medicine and Moores Cancer Center at UC San Diego Health have identified a strong association between the product of a geneexpressed in most cancers, including the most common type of head and neck cancer, and elevated levels of white blood cells that produce antibodies within tumors.
Researchers at Baylor College of Medicine and Rice University have found a new way to do just that […]. The function of a protein can depend on its abundance in a cell. So, when investigating the properties of a new protein, it is essential to make sure that the same amount is produced by every cell.
Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Algorithm maps geneexpression in space.As we accumulate more and more gene-sequencing information, cell-type databases are growing in both size and complexity.
BostonGene Announces Publication in Clinical Cancer Research Identifying the Cellular Features and GeneExpression Characteristics Underlying MRI Visibility in Prostate Cancer BostonGene Announces Publication in Clinical Cancer Research Identifying the Cellular Features and GeneExpression Characteristics Underlying MRI Visibility in … Continue (..)
Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Researchers identify key RNA “gatekeeper” in geneexpression, pointing to possible new drug targets.An
Mount Sinai researchers have discovered that Polycomb complexes, groups of proteins that maintain geneexpression patterns, are essential for proper skin development, according to a paper published in Genes & Development on February 18.
Just as it’s hard to understand a conversation without knowing its context, it can be difficult for biologists to grasp the significance of geneexpression without knowing a cell’s environment.
An international research team, including researchers at Karolinska Institutet, has mapped the genesexpressed in the brain cells of people with multiple sclerosis (MS). The atlas, which is presented in the journal Neuron, is hoped to contribute to more personalized treatment of MS in the future.
New Research Reveals the Secret Behind a Key Cellular Process (scitechdaily.com) New research has identified and described a cellular process that, despite what textbooks say, has remained elusive to scientists until now — precisely how … Continue reading → Source : Biology Textbooks Wrong?
Blocking geneexpression in mitochondria in mice stops cancer cells from growing Credit: Hauke S. Researchers from the Max Planck Institute for Biology of Ageing in […]. Hillen A newly developed compound starves cancer cells by attacking their “power plants” – the so-called mitochondria.
Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Protein that manipulates geneexpression inside the cell nucleus could inspire new RSV drugs, vaccines.Protein that manipulates geneexpression inside the cell nucleus could inspire new RSV … Continue reading →
It is a comprehensive term which encompasses a large variety of therapy products including viral and bacterial vectors, plasmid DNA, human gene editing technology, and patient-specific cellular gene therapy. Additionally, gene editing allows us either to remove or to modify harmful genes. GeneExpression Considerations.
Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: New, reversible CRISPR method can control geneexpression while leaving underlying DNA sequence unchanged.Over the past decade, the CRISPR-Cas9 gene editing system has revolutionized genetic engineering, allowing … Continue (..)
In recent webinars by Genuity Science, formerly known as WuXi NextCODE, experts from the biotech and pharma industries spoke about leveraging the power of single cell RNA sequencing platforms and solutions in conjunction with machine learning technologies such as AI in cell biology and disease research. The Power of Single Cell Technology.
A data-mining study conducted by researchers in the US has found that an already-approved diuretic drug could have potential as a treatment for some patients with Alzheimer’s disease. The results are strong enough to back a proof-of-concept study in people with genetic risk of Alzheimer’s according to the researchers.
If humans are ever going to be able to regrow damaged tissues the way lizards and fish routinely do, it will require the precise control of geneexpression in time and place—otherwise you might end up with random cells growing everywhere or a new body part that never quits growing.
Credit: Nucleic Acids Research Scientists at Tokyo Institute of Technology decipher how to quantitatively assess the effects of specific epigenetic changes on the rate of transcription by developing a mathematical model. Their study published in Nucleic Acids Research provides an accurate quantitative approach […].
Credit: Henry Ford Health System Findings from a research study, led by scientists at Henry Ford, published in the latest issue of Nature Communications suggest an enzyme could play an important role in the treatment of cancer and autoimmune diseases in the airway.
Let’s explore some of the innovative research and emerging trends shaping the epilepsy treatment landscape in this blog. Exploring Innovation in Epilepsy on Purple Day 2025 The progress seen in epilepsy research over recent years is nothing short of inspiring. Imaging and biomarker research are improving diagnostic precision.
Many of these adaptations are mediated through two-component signal transduction systems (TCSs) that coordinate geneexpression in response to environmental stimuli. In a new study reported in the Journal of Bacteriology, researchers at Illinois provide insight into the signal transduction mechanism […].
Researchers from the Cardiology Department at the University Medical Center Mainz have now discovered that noise exposure (average sound pressure level 72 dB; peak level 85 dB) up to 4d resulted in pro-inflammatory aortic geneexpression in mice.
Individuals with cocaine use disorder exhibit geneexpression changes in two brain regions: the nucleus accumbens, a region associated with reward, and the caudate nucleus, a region mediating habit formation, according to research conducted at the Icahn School of Medicine at Mount Sinai and published February 10 in Science Advances.
Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: A new method for mapping geneexpression deep in the body could one day be used to track stem cells or cancer therapy.Even fans of black-and-white film … Continue reading →
First study to show geneexpression changes in divers with ‘the bends’ reveals key role of genes for inflammation and immunity For over a century, researchers have known about “the bends”, a serious condition affecting scuba divers. Doctors do not yet have a definitive test […].
A form of blood cancer known as mantle cell lymphoma is critically dependent on a protein that coordinates geneexpression, such that blocking its activity with an experimental drug dramatically slows the growth of this lymphoma in preclinical tests, according to a study from Weill Cornell Medicine researchers.
Researchers in the US have developed an artificial intelligence-based tool that is able to predict COVID-19 symptoms and suggest which FDA-approved drugs might be used to treat patients. It could also be made more powerful by incorporating personal genetic information and geneexpression profiles in tissues such as the lungs, they suggest.
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