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Jude Children’s Research Hospital scientists have developed a highly efficient method to address a major challenge in biology–identifying the genetic ‘switches’ that regulate geneexpression. Jude Children’s Research Hospital St. Credit: St.
A University of Minnesota Twin Cities-led team has developed a new technique that allows scientists and engineers to, for the first time, visualize mRNA molecules in the brains of living mice.
New Research Reveals the Secret Behind a Key Cellular Process (scitechdaily.com) New research has identified and described a cellular process that, despite what textbooks say, has remained elusive to scientists until now — precisely how … Continue reading → Source : Biology Textbooks Wrong?
A data-mining study conducted by researchers in the US has found that an already-approved diuretic drug could have potential as a treatment for some patients with Alzheimer’s disease. The results are strong enough to back a proof-of-concept study in people with genetic risk of Alzheimer’s according to the researchers.
Credit: Henry Ford Health System Findings from a research study, led by scientists at Henry Ford, published in the latest issue of Nature Communications suggest an enzyme could play an important role in the treatment of cancer and autoimmune diseases in the airway.
Researchers in the US have developed an artificial intelligence-based tool that is able to predict COVID-19 symptoms and suggest which FDA-approved drugs might be used to treat patients. The tool meanwhile could also be applied to new outbreaks of other novel viral infections as they emerge, according to the scientists.
Credit: Nucleic Acids ResearchScientists at Tokyo Institute of Technology decipher how to quantitatively assess the effects of specific epigenetic changes on the rate of transcription by developing a mathematical model. Their study published in Nucleic Acids Research provides an accurate quantitative approach […].
Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Understudied mutations have big impact on gene expression.An
For the first time, researchers describe how Rho protein really stops geneexpression COLUMBUS, Ohio – New research has identified and described a cellular process that, despite what textbooks say, has remained elusive to scientists until now – precisely how the copying of genetic material that, once started, is properly turned off.
The 2024 Nobel Prize in Physiology or Medicine has been awarded to American scientists Victor Ambros and Gary Ruvkun for their groundbreaking discovery of microRNA (or miRNA) and its role in post-transcriptional gene regulation. Last year’s Nobel Prize in Physiology and Medicine also went to RNA researchers.
Researchers at the University of North Carolina at Chapel Hill and the UNC Lineberger Comprehensive Cancer Center have uncovered a new role of a chromatin-modulatory enzyme, termed EZH2, during cancer development. PROTAC addresses this gap,” said Jun Wang, PhD, postdoctoral researcher at UNC Lineberger and co-first author of the work.
Researchers at the University of California San Francisco (UCSF) and the Whitehead Institute have developed a novel CRISPR-based tool called “CRISPRoff” that can switch off genes in human cells through epigenetic editing without altering the genetic sequence itself. The research was published earlier this month in the journal Cell.
Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Enabling cells to talk to computers.Genetically encoded reporter proteins have been a mainstay of biotechnology research, allowing scientists to track geneexpression, understand intracellular processes and debug … Continue (..)
Scientists discover small RNA that regulates bacterial infection People with weakened immune systems are at constant risk of infection. However, researchers at the Georgia Institute of Technology have identified the major mechanism behind the transition between chronic and acute P. aeruginosa infections. and Nelson D.
The challenge in unlocking their potential to inform drug discovery is to work out which variants regulate which genes in which cell types and whether they exert a positive or negative impact on geneexpression, according to the biotech. Dr Danuta Jeziorska.
Scientists from the German Cancer Research Center (DKFZ) and the Medical Faculty Mannheim, Heidelberg University, have now identified a new growth factor produced by blood vessels that enables tumor cells to metastatically colonize organs.
Researchers at the University of California San Francisco (UCSF) and the Whitehead Institute have developed a novel CRISPR-based tool called “CRISPRoff” that can switch off genes in human cells without editing the genetic sequence itself. These modifications regulate geneexpression without altering the sequence or structure of DNA.
The microbiome has been the focus of research for 20 years – ever since a new technique made it possible to analyse these bacteria quickly and precisely: high-throughput sequencing. The research team published the results of its study in the journal Nature Communications. The immune system is mentioned particularly frequently.
The researcher at the Max Planck Institute for Developmental Biology received the award in a virtual ceremony for her groundbreaking research on the human microbiome – the totality of all microorganisms that naturally colonize a healthy human – which can reach an impressive mass of approximately one kilogram.
By combining CRISPR technology with a protein designed with artificial intelligence (AI), it is possible to awaken individual dormant genes by disabling the chemical “off switches” that silence them. Researchers from the University of Washington School of Medicine in Seattle describe this finding in the journal Cell Reports.
Physician and researcher Dr. Daniel L Marks discusses the historial challenges to developing a therapeutic for this condition and what may finally be on the horizon. . Until recently, cancer research and resulting therapeutic approaches have focused on one thing: “get the tumour.” 4 receptor (MC4R).
Recent advances in DNA sequencing technologies have led to significant developments in healthcare-focused research on precision medicine and diagnostics. According to a study, around 20,000 genes are present in the human body, all of which interact with the nutrients in the food, either directly or indirectly.
Much of the fundamental groundwork for genetics and genomic research was laid in the 20 th century, with significant contributions from women scientists, some of whom worked during times when acceptance of female researchers was not widespread. Rosalind Franklin: From Chemistry to Genetics.
After being identified in December 2019 in Wuhan, Hubei in China, medical officials and scientists got to work to isolate and identify the novel virus that they observed to be causing a new respiratory illness. By re-tooling it, they were able to develop CRISPR/Cas9, a precision gene editing technology that can be used in any living organism.
UCSF scientists found that having an additional copy of the sex chromosome gives women two “doses” of a gene found only on that chromosome. The new research provides insight into how sex chromosomes affect susceptibility to Alzheimer’s, and how they can impact the course and severity of the disease. The Active Gene.
Epigenetics is a multi-billion dollar area of research, studied throughout the world and funded by health institutions, universities and by governments. It shows us that we can directly affect a gene’s damaging behavior so that it no longer hurts us. So identical twins can have identical genes – yet different genetic illnesses.
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