XTalks

OCTOBER 8, 2024

The 2024 Nobel Prize in Physiology or Medicine has been awarded to American scientists Victor Ambros and Gary Ruvkun for their groundbreaking discovery of microRNA (or miRNA) and its role in post-transcriptional gene regulation. Last year’s Nobel Prize in Physiology and Medicine also went to RNA researchers.

Regulation 52

Regulation Genetics Scientist RNA 52

Scienmag

DECEMBER 10, 2020

Credit: Nucleic Acids Research Scientists at Tokyo Institute of Technology decipher how to quantitatively assess the effects of specific epigenetic changes on the rate of transcription by developing a mathematical model. For this, they successfully generated reconstituted chromatin bearing histone modifications in vitro.

Gene Expression 52

Gene Expression In-Vitro Gene Scientist 52

BioTech 365

DECEMBER 4, 2020

New Research Reveals the Secret Behind a Key Cellular Process (scitechdaily.com) New research has identified and described a cellular process that, despite what textbooks say, has remained elusive to scientists until now — precisely how … Continue reading →

Gene Expression 52

Gene Expression Protein Research Gene 52

BioTech 365

APRIL 12, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Understudied mutations have big impact on gene expression.An

Gene Expression 40

Gene Expression Gene Scientist Research 40

Scienmag

SEPTEMBER 29, 2020

By changing gene expression first, some immunotherapies may work better, models show Credit: (courtesy of Hackensack Meridian Health) September 29, 2020 – Nutley, NJ – A one-two punch of changing gene expression, then deploying immune checkpoint inhibitors, shows promise in battling one of the most treatment-resistant types of cancer in (..)

Gene Expression 52

Gene Expression Scientist Gene Clinical Trials 52

Scienmag

JULY 1, 2022

In a new study, scientists use gene expression patterns, called transcriptomics, to […]. . — The fossil record tells us about ancient life through the preserved remains of body parts like bones, teeth and turtle shells.

Gene Expression 63

Gene Expression Gene Scientist 63

Scienmag

MARCH 19, 2021

Credit: Thomas Gorochowski In a recent study led by the University of Bristol, scientists have shown how to simultaneously harness multiple forms of regulation in living cells to strictly control gene expression and open new avenues for improved biotechnologies.

Gene 75

Gene Gene Expression Engineer Scientist 75

Scienmag

AUGUST 4, 2020

Credit: Henry Ford Health System Findings from a research study, led by scientists at Henry Ford, published in the latest issue of Nature Communications suggest an enzyme could play an important role in the treatment of cancer and autoimmune diseases in the airway.

Gene Expression 82

Gene Expression Gene Scientist Research 82

Scienmag

MARCH 17, 2021

An international team of scientists from the University of Turku, Finland and PennState University, USA have solved a long-standing mystery of how living organisms distinguish RNA and DNA building blocks during gene expression paving the way for the design of new antiviral drugs. All cellular […].

Gene Expression 74

Gene Expression RNA DNA Drugs 74

The Pharma Data

FEBRUARY 24, 2022

UNC researchers now show that these two factors can directly associate with one another, modulating cancer-cell-specific programs of gene expression. Notably, these mechanisms include those driven by EZH2, a chromatin-modulatory enzyme, and cMyc, a prominent cancer-causing factor.

Scientist 52

Scientist Gene Expression Gene Genome 52

pharmaphorum

OCTOBER 12, 2021

The research by a team of National Institutes of Health (NIH) scientists found that people who took bumetanide, a generic drug usually used to treat heart failure and oedema, had a significantly lower prevalence of Alzheimer’s compared to those not taking the drug.

Gene Expression 111

Gene Expression Drugs FDA Approval Gene 111

Scienmag

NOVEMBER 26, 2020

For the first time, researchers describe how Rho protein really stops gene expression COLUMBUS, Ohio – New research has identified and described a cellular process that, despite what textbooks say, has remained elusive to scientists until now – precisely how the copying of genetic material that, once started, is properly turned off.

Gene Expression 54

Gene Expression Genetics Protein Gene 54

BioTech 365

AUGUST 25, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Enabling cells to talk to computers.Genetically encoded reporter proteins have been a mainstay of biotechnology research, allowing scientists to track gene expression, understand intracellular processes and debug … Continue (..)

Gene Expression 40

Gene Expression Protein Gene Scientist 40

The Pharma Data

JUNE 14, 2023

Scientists discover small RNA that regulates bacterial infection People with weakened immune systems are at constant risk of infection. Abell Chair in Molecular and Cellular Biology – and Pengbo Cao, a postdoctoral researcher in Whiteley’s lab, discovered a gene that drives the switch.

RNA 40

RNA Regulation Scientist Bacteria 40

Scienmag

APRIL 5, 2021

Study shows that tumor-suppressor protein p53 brings speckles and DNA together to boost gene expression PHILADELPHIA – A team led by scientists at the Perelman School of Medicine at the University of Pennsylvania has illuminated the functions of mysterious structures in cells called “nuclear speckles,” showing that they can work in (..)

Gene 42

Gene Gene Expression DNA Protein 42

pharmaphorum

NOVEMBER 12, 2021

The MOATAI-VIR algorithm, developed by scientists at Emory University and Georgia Tech, was put through its paces in a study that showed it was able to predict 24 out of 26 clinical manifestations of COVID-19, including acute respiratory distress, blood clotting issues, cytokine storms, brain fog, and loss of smell or taste. .

Doctors 135

Doctors Doctor Drugs Gene Expression 135

pharmaphorum

OCTOBER 19, 2022

The challenge in unlocking their potential to inform drug discovery is to work out which variants regulate which genes in which cell types and whether they exert a positive or negative impact on gene expression, according to the biotech.

Genomics 59

Genomics Genome Gene Gene Expression 59

XTalks

MAY 4, 2021

These modifications regulate gene expression without changing the sequence or structure of DNA. In the paper, the scientists also describe the CRISPRon “antidote,” which removes methylation marks placed by CRISPRoff, making the process fully reversible. It’s a great tool for controlling gene expression.”.

DNA 91

DNA Gene Gene Silencing Genome 91

The Pharma Data

SEPTEMBER 2, 2021

Scientists from the German Cancer Research Center (DKFZ) and the Medical Faculty Mannheim, Heidelberg University, have now identified a new growth factor produced by blood vessels that enables tumor cells to metastatically colonize organs. In fact, scientists were able to slow the metastatic growth of breast and lung tumors in this way.

Gene Expression 52

Gene Expression Scientist Antibody Research 52

XTalks

MAY 4, 2021

These modifications regulate gene expression without altering the sequence or structure of DNA. In the paper, the scientists also describe the CRISPRon “antidote,” which removes methylation marks placed by CRISPRoff, making the process fully reversible. It’s a great tool for controlling gene expression.”.

DNA 52

DNA Gene Gene Silencing Genome 52

pharmaphorum

MARCH 10, 2021

bluebird bio is to ask regulators to restart clinical studies of its LentiGlobin for sickle cell disease, after an investigation concluded that a case of acute myeloid leukaemia (AML) was “very unlikely” to be caused by the gene therapy. The post bluebird seeks gene therapy trial restart after cancer scare appeared first on.

Gene Therapy 53

Gene Therapy Gene Trials Gene Expression 53

The Pharma Data

JULY 11, 2021

Scientists at the Universities of Würzburg and Marburg have now succeeded for the first time in experimentally demonstrating that bacterial metabolites are able to increase the cytotoxic activity of certain immune cells and thus positively influence the efficiency of tumour therapies. The immune system is mentioned particularly frequently.

Bacteria 52

Bacteria Genetics Scientist Regulation 52

The Pharma Data

FEBRUARY 22, 2021

Born in 1970, the British and American research scientist has been Director of the Department of Microbiome Research at the Max Planck Institute for Developmental Biology in Tübingen since 2016. We are very pleased to honor today a true pioneer and outstanding scientist in microbiome research.”.

Scientist 40

Scientist Life Science Research Gene Expression 40

Roots Analysis

AUGUST 31, 2023

At present, extensive studies are being conducted to understand the interaction between nutrients and gene expression at the molecular level, to determine the effect of a specific nutrient and dietary regime on human health. In part, the success of the Human Genome Project has also paved a path for the novel concept of nutrigenomics.

Genome 40

Genome Genomics Genetics Gene 40

The Pharma Data

MARCH 7, 2022

Because these modifications occur not in, but on top of genes, they are called epigenetic, from the Greek epi “over” or “above” the genes. The chemical modifications that regulate gene activity are called epigenetic markers. Cas9 is the protein used in the gene editing process called CRISPR.

Protein 52

Protein Gene Genome Genomics 52

pharmaphorum

JUNE 3, 2021

Further evidence of its potential efficacy as a drug candidate was also established based on diminished hypothalamic inflammatory gene expression. Marks is an established physician scientist with experience leading clinical research studies. About the author. Dr. Daniel L.

Gene Expression 40

Gene Expression Research Drugs Medicine 40

XTalks

FEBRUARY 11, 2021

Much of the fundamental groundwork for genetics and genomic research was laid in the 20 th century, with significant contributions from women scientists, some of whom worked during times when acceptance of female researchers was not widespread. The marriage ended in divorce after a few short years. Marie Maynard Daly: Breaking Barriers.

Genetics 119

Genetics DNA Genome Genomics 119

XTalks

SEPTEMBER 21, 2020

UCSF scientists found that having an additional copy of the sex chromosome gives women two “doses” of a gene found only on that chromosome. To further confirm these results, the scientists deleted the second X in female Alzheimer’s mice, which led them to be more cognitively impaired like males and die faster. The Active Gene.

Gene 62

Gene Protein Gene Expression Scientist 62

The Pharma Data

MAY 15, 2021

It’s because certain genes act one way on some people… and another way on other people. Putting this in medical jargon, the gene ‘expresses’ one way with Bob, for example, and a completely different way with Mary. How a gene expresses – that is, how the gene affects you – goes on to determine whether you get ill or not.

Bacteria 52

Bacteria Gene Gene Therapy Gene Expression 52

XTalks

DECEMBER 24, 2020

After being identified in December 2019 in Wuhan, Hubei in China, medical officials and scientists got to work to isolate and identify the novel virus that they observed to be causing a new respiratory illness. By re-tooling it, they were able to develop CRISPR/Cas9, a precision gene editing technology that can be used in any living organism.

Life Science 102

Life Science Vaccine Vaccination Gene 102