article thumbnail

Takeda grows in gene therapies again with $2bn Code Bio deal

pharmaphorum

Code Bio’s 3DNA vectors are based on pieces of synthetic DNA linked together to form a scaffold that can carry a larger gene sequence than viral vectors, and according to the biotech don’t trigger an immune response which might cause side effects or limit the potential for re-dosing.

article thumbnail

Medicago, GSK’s plant-made COVID jab clears phase 2

pharmaphorum

.” The interim phase 2 results show that two doses of the plant-derived jab stimulated neutralising antibody levels that are around 10 times higher than those in a panel of sera from patients recovering from COVID-19, with a similar response seen in adults and the elderly.

article thumbnail

Zynteglo halt re-ignites viral vector safety concerns; analysts

pharmaphorum

That therapy uses an adeno-associated virus (AAV) as a vector rather than a lentivirus, a vector type that features in approved gene therapies such as Roche’s Luxturna and Novartis’ Zolgensma. million in Europe.