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New CRISPR-Based Tool Called PASTE Gene Editing Inserts Large DNA Sequences at Desired Sites

XTalks

The objective of Abudayyeh and Gootenberg’s research was to develop a gene editing tool that can facilitate the splicing and replacement of a defective gene sequence without double-stranded breaks in DNA. The researchers reported very few unwanted deletions or insertions at the sites of gene integration.

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Touchlight boosts DNA manufacturing capacity with latest expansion

Pharmaceutical Technology

Tripling its production capacity, Touchlight can now manufacture 8kg plasmid DNA, a key component for mRNA gene therapies and vaccines. As per the company, dbDNA is suitable for rapid, scalable manufacture of GMP DNA and can incorporate gene sequences of sizes ranging from 500bp to 20kb, which are typically unstable as pDNA.

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