Delveinsight

DECEMBER 10, 2020

The body’s immune system falsely attacks insulin-making beta cells in the pancreas in Type 1 diabetes. UniQure/CSL haemophilia B gene therapy curbs bleeding in phase 3. Its recent data infer that it could work for patients considered unsuited for gene therapy. The Lancet paper offers background on how the U.K.

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XTalks

FEBRUARY 6, 2024

Revita, an outpatient endoscopic procedural therapy, which aims to eliminate insulin needs and enhance glycemic control by ablating dysfunctional duodenal mucosa. In a recent development, Fractyl Health announced the selection of RJVA-001 as its inaugural clinical T2D candidate in the Rejuva gene therapy platform.

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BioSpace

NOVEMBER 17, 2022

Editas Medicine is pausing its ocular gene therapy program after demonstrating a favorable safety profile and seeking a potential partner to develop EDIT-101, the company announced Thursday.

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BioPharma Reporter

JUNE 25, 2024

Results from a phase 1/2 clinical trial revealed that PolTREGâs regulatory T cell (Treg) therapy, PTG-007, was able to restore insulin secretion in children with type-1 diabetes.

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Pharma Packaging Solutions

JUNE 30, 2023

Hormones (such as insulin, glucagon, and growth hormone, to name a few) are produced by recombinant DNA, as are blood factors, thrombolytic agents, interferons, monoclonal antibodies, therapeutic enzymes, and more.

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Pharmaceutical Technology

JANUARY 31, 2023

While insulin price caps will begin this year, larger effects will be delayed until 2026 – when the US federal government will be allowed to negotiate Medicare prices and demand rebates from drug companies that price gouge. It’s much needed. It’s a hot area.”

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XTalks

JULY 27, 2022

Dr. Toleikis spoke about the latest clinical trial data for the medical device, and also about the company’s new partnership with Evotec to integrate its insulin-producing cells in the Cell Pouch System. Toleikis about Sernova’s proprietary Cell Pouch System that is designed to house therapeutic cells.

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Life Science Insulin Clinical Trials Clinical Trials 52

XTalks

JANUARY 21, 2025

Companion diagnostic for Pfizers hemophilia B gene therapy Beqvez (idanacogene elaparvovec-dzkt). The test is designed for identifying individuals with moderate to severe hemophilia B (congenital factor IX [FIX] deficiency) who may benefit from the gene therapy Beqvez.

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Delveinsight

AUGUST 20, 2020

FDA rejects BioMarin’s gene therapy and Gilead’s filgotinib over concerns. The FDA refused to approve BioMarin’s hemophilia A gene therapy valoctocogene roxaparvovec. The removal of an AdComm was seen as a positive. Immune-evading cells with PD-L1 control diabetes in mice.

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pharmaphorum

AUGUST 24, 2021

It will focus on ‘ex vivo’ therapies, which involves harvesting cells from patients, modifying them and then infusing then back into the body. If approved, it could mount a challenge to bluebird bio’s gene therapy Zynteglo, which is already approved in Europe.

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Roots Analysis

SEPTEMBER 22, 2023

Diabetes : These devices offer an effective solution for delivering insulin, improving glycemic control, and enhancing the quality of life for diabetic patients. The historical trends of existing delivery devices, such as prefilled syringes, autoinjectors and insulin pumps, suggest a strong demand in the market.

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Roots Analysis

JANUARY 14, 2024

Usually, the desired gene, such as human insulin gene, when inserted into the plasmid of the host cell uses transcriptional and translational machinery of the host to express itself. It is worth mentioning that in vitro gene expression requires a suitable host for the production of a specific gene product.

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XTalks

AUGUST 2, 2023

Meanwhile, BioMarin’s gene therapy Roctavian is approved by the FDA for the treatment of hemophilia A. It is a dipeptidyl peptidase-4 inhibitor that keeps insulin levels stable and reduces the amount of glucose produced by the body. But all three drugs have new competitors. Both are anti-CD20 agents. billion in 2022.

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pharmaphorum

SEPTEMBER 1, 2020

The first was insulin – Frederick Banting and colleagues managed to isolate insulin that could treat diabetes, up until that point a fatal condition. The period between 1918 and 1939 was marked by two breakthroughs that presaged the arrival of the pharma industry as we know it today.

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XTalks

AUGUST 30, 2024

These breakthroughs, combined with the growing focus on gene therapy, oncology and immunology, have brought these companies to the forefront of global healthcare. The recent partnership to produce affordable insulin in Africa aims to reach over four million people by 2026, reflecting Novo Nordisk’s commitment to global health equity.

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pharmaphorum

JANUARY 10, 2023

The one-shot therapy is expected to provide long-lasting effects, reduce the number of bleeds experienced by patients, and reduce the need Factor VIII replacement therapy.

Drugs 52

Drugs Gene Therapy Antibody Insulin 52

Pharmaceutical Technology

MAY 17, 2023

It is no exaggeration to say that the world changed in the early 80s when insulin was expressed synthetically in microorganisms for the first time. This breakthrough led to a recombinant (biosynthetic) and thereby safer therapy for diabetes than the animal-sourced insulin which had been used since 1922.

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The Pharma Data

MAY 6, 2021

CSL closes deal for UniQure gene therapy in hopeful sign for M&A ( BioPharmaDive ). Dyno raises $100 million to bring artificial intelligence to gene therapy ( STAT ). Lilly inks smart insulin pen deals with Roche, Dexcom and more ( Fierce ). OcuWho? .

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