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Takeda has forged another alliance as it continues a push into gene therapy, agreeing a deal worth up to $2 billion with Code Biotherapeutics for opt-in rights to four candidates for rare diseases. The post Takeda grows in gene therapies again with $2bn Code Bio deal appeared first on. Last October it signed a $3.6 billion-plus.
Credit: Elizabeth Cooke Next-generation genesequencing (NGS) technologies –in which millions of DNA molecules are simultaneously but individually analyzed– theoretically provides researchers and clinicians the ability to noninvasively identify mutations in the blood stream.
New method yields 10 times more data, reduces genesequencing costs by one third Researchers have devised a way to multiply by more than ten-fold the accessible details of gene activity in individual cells.
The three-year project – led by respiratory medicine expert Dr Timothy Hinks from the Oxford University Respiratory Medicine Unit – will use whole-genome sequencing of around 500 patients with severe asthma, comparing their genesequences with control subjects who don’t have asthma.
18 months after signing its first partnering deal with Genentech, Scenic Biotech has raised $31 million in first-round financing that it will use to take its own genetic modifier-targeted medicines into clinical trials.
Vertex Pharma has ramped up its involvement in gene-editing medicines for the second time in a week, paying Obsidian Therapeutics $75 million upfront to access its technology platform. . For example, adding a small-molecule might stabilise the medicine, allowing levels of the target protein to increase.
The neoantigens are selected based on genesequencing of either a tumour biopsy or a blood sample, with an individual vaccine tailored to the patient manufactured and administered in a matter of weeks.
Since the introduction of a genesequencing method by Frederick Sanger in 1977, the field of genomic data collection and analysis has evolved significantly. Advancement in DNA sequencing technologies have resulted in noteworthy developments in various healthcare-related research fields, such as diagnostics and personalized medicine.
Cambridge, UK-based Biofidelity has raised $12 million in first-round funding for its cancer diagnosis platform, which can detect mutations quicker than current approaches like genesequencing. Longwall Ventures and Agilent have both returned to invest in the Series A, which on this occasion was led by BlueYard Capital.
The advantage of plant-based production is that it is quick – Medicago says it produced the main ingredient for its vaccine just 20 days after the genesequence of SARS-CoV-2 was published – and is easily scalable simply by cultivating additional plants.
Tripling its production capacity, Touchlight can now manufacture 8kg plasmid DNA, a key component for mRNA gene therapies and vaccines. As per the company, dbDNA is suitable for rapid, scalable manufacture of GMP DNA and can incorporate genesequences of sizes ranging from 500bp to 20kb, which are typically unstable as pDNA.
In November 2019 it was licensed for use by the European Medicines Agency and is now prequalified by WHO, the US FDA, as well as in eight African countries. This is a priority area for us to ensure that all African countries are equipped to carry out genesequencing locally or can send samples to reference laboratories.”.
Rather, developers of diagnostic tests and, indeed of any product that relies on free access to genesequence and other biomarker information, should pay also close attention, as PERA would overturn longstanding judicial precedent. By 2010, about 2000 isolated human genes had been patented in the U.S.
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