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An analysis of genetic data collected from more than 850,000 individuals of European ancestry has found a link between obesity-related genes and rheumatoid arthritis.
. “The potential utility of this is that it can be used to define men who are at elevated risk of developing prostate cancer,” said lead author Christopher Haiman, professor of preventive medicine at Keck School of Medicine at the University of Southern California (USC) in Los Angeles.
12) — Columbia researchers have uncovered an array of new genes that cause stillbirth, significantly increasing the understanding of the condition’s genetic foundations. The findings suggest that geneticanalysis could be used to counsel parents who have previously experienced stillbirth and to unlock new human biology.
Comparing four separate forms of the disease, they found that samples of the most aggressive form, known as metastases-like primary tumours, saw changes in activity of 74 immune-related genes, compared with changes in only 12 in the more benign insulinoma-like tumours.
Geneticanalysis of tumours can reveal mutations that are fuelling cancers growth, some of which can be targeted with treatment, they note. They then used the AI to predict sensitivity to drug combinations, using 21 different two-drug combinations in lung cancer cells with different gene faults, such as mutations in EGFR and KRAS.
A new largescale geneticanalysis has found biological mechanisms that contribute to making people more susceptible to muscle weakness in later life, finding that diseases such as osteoarthritis and diabetes may play a large role in susceptibility.
Beam Therapeutics has taken over a startup whose technology could proffer the biotech’s geneticmedicines to more tissues in the body, widening the potential to approach more diseases. Cambridge, Massachusetts-based Beam aims to make more precise edits with geneticmedicines, which employ base-editing.
The risk profile of developing AMD has been studied for years,” he said, “and more than 50% of a given individual’s risk profile is dependent on their genetics. So, pegcetacoplan blocks an inflammatory pathway that appears to be central for geopathic genesis based on extensive geneticanalysis,” Dr Wykoff concluded.
Whether its the integration of nanotechnology in medicine, the evolution of point-of-care (POC) diagnostics or the transformative impact of CRISPR and regenerative medicine, these biotech trends are pushing scientific boundaries and creating new opportunities for businesses and researchers alike. percent from 2022 to 2030.
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