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Genetic analysis links obesity to higher rheumatoid arthritis risk

Scienmag

An analysis of genetic data collected from more than 850,000 individuals of European ancestry has found a link between obesity-related genes and rheumatoid arthritis.

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Genes Help Explain Role of Race in Prostate Cancer Risk

The Pharma Data

. “The potential utility of this is that it can be used to define men who are at elevated risk of developing prostate cancer,” said lead author Christopher Haiman, professor of preventive medicine at Keck School of Medicine at the University of Southern California (USC) in Los Angeles.

Gene 52
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After Stillbirth, New Genetic Analyses May Give Parents Answers

Scienmag

12) — Columbia researchers have uncovered an array of new genes that cause stillbirth, significantly increasing the understanding of the condition’s genetic foundations. The findings suggest that genetic analysis could be used to counsel parents who have previously experienced stillbirth and to unlock new human biology.

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Immunotherapies could target aggressive pancreatic cancer, research indicates

The Pharma Data

Comparing four separate forms of the disease, they found that samples of the most aggressive form, known as metastases-like primary tumours, saw changes in activity of 74 immune-related genes, compared with changes in only 12 in the more benign insulinoma-like tumours.

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AI test could predict best cancer therapies for patients

pharmaphorum

Genetic analysis of tumours can reveal mutations that are fuelling cancers growth, some of which can be targeted with treatment, they note. They then used the AI to predict sensitivity to drug combinations, using 21 different two-drug combinations in lung cancer cells with different gene faults, such as mutations in EGFR and KRAS.

Protein 67
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New research identifies biological causes of muscle weakness in later life

Scienmag

A new largescale genetic analysis has found biological mechanisms that contribute to making people more susceptible to muscle weakness in later life, finding that diseases such as osteoarthritis and diabetes may play a large role in susceptibility.

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Beam makes USD 120M bet; GRAIL and Quest announce the collaboration; Brain organoids mimic infant’s brains; Improvement in T cells to kill cancer

Delveinsight

Beam Therapeutics has taken over a startup whose technology could proffer the biotech’s genetic medicines to more tissues in the body, widening the potential to approach more diseases. Cambridge, Massachusetts-based Beam aims to make more precise edits with genetic medicines, which employ base-editing.

DNA 52