Drug Discovery World

NOVEMBER 17, 2022

The rapidly growing area of synthetic biology – including molecular biology, biotechnology, biophysics, and genetic engineering – is having a marked impact on the drug discovery landscape. The Brady lab has been finding antibacterial genes in soil and growing them within more lab-friendly bacteria.

Bacteria 52

Bacteria Engineer Gene Genetics 52

Drug Discovery World

JUNE 27, 2024

Scientists at the University of Sydney have developed a gene-editing tool with greater accuracy and flexibility than CRISPR. SeekRNA uses a programmable ribonucleic acid (RNA) strand that can directly identify sites for insertion in genetic sequences, simplifying the editing process and reducing errors.

Gene Editing 59

Gene Editing Gene DNA Genetic Engineering 59

Drug Discovery World

MARCH 13, 2023

The cell and gene therapy (CGT) landscape has grown significantly in the past year. One example: Zynteglo, a newly approved gene therapy priced at a record-breaking $2.8M It has taken a concerted effort to evolve cell and gene therapies into what they are today, and the technology is advancing faster than ever. Fierce Pharma.

Gene Therapy 52

Gene Therapy Gene Manufacturing Development 52

Drug Discovery World

JULY 22, 2022

By Courtney Ferrebee, PhD, Field Applications Scientist, Taconic Biosciences. The future could involve creating genetically engineered DCs or “CAR-DC” cells using patient-derived neoantigen-loaded cells to improve clinical outcomes 30. Courtney Ferrebee, PhD, is a field applications scientist at Taconic Biosciences.

In-Vivo 52

In-Vivo Engineer In-Vitro Medicine 52

Drug Discovery World

SEPTEMBER 28, 2022

Scientists from Tel Aviv University have deciphered the mechanism that enables skin cancer to metastasise to the brain and were able to delay the spread of the disease by 60-80% using existing treatments. . Once melanoma, or skin cancer, spreads to the brain, it becomes extremely aggressive.

Research 52

Research Gene Editing Genetic Engineering Protein 52

Drug Discovery World

JANUARY 23, 2023

Kevin Hemphill, R&D Manager at PerkinElmer’s Horizon Discovery explores how base editing has emerged as an attractive gene editing option for researchers wanting to develop stem cell-based therapies. Adult fibroblasts were cultured in a cocktail of transcription factors to reactivate embryonic gene expression patterns 2.

Gene Editing 52

Gene Editing Gene Engineer DNA 52

Drug Discovery World

NOVEMBER 9, 2023

Gail Calvert, Field Application Scientist, Sartorius UK, on: ‘Leveraging integrated and advanced technologies for successful cell line development’. Engineering for higher avidity and multi-valency Following chairperson’s remarks from Bruce Keyt, PhD, CSO, R&D, IGM Biosciences, there will be three presentations in this session.

Engineer 52

Engineer Antibody Protein In-Vivo 52

pharmaphorum

SEPTEMBER 13, 2022

During this period, Nobel prize-winning German scientist Paul Ehrlich developed his lock-key hypothesis of molecules that specifically bind to cell receptors. Building on the success of cytokine-based immunotherapies, scientists continued to seek other areas where the immune system could be leveraged against tumours.

Genome Project 94

Genome Project Genome Genomics DNA 94

Drug Discovery World

FEBRUARY 15, 2023

Genetically modified T cells stimulated with IL2 are now administered as cell therapy for multiple cancer cell types with beneficial results 3,4. Genetically engineered mouse models (GEMM) recapitulate the stromal biology of different human cancers including the tumour microenvironment that regulates the disease process.

Research 52

Research In-Vitro In-Vivo Development 52