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New ‘split-drive’ system puts scientists in the (gene) driver seat

Scienmag

Researchers develop tunable system that harnesses the spread of cargo carried by gene drives Credit: Gerard Terradas, UC San Diego Powerful new genetic engineering methods have given scientists the potential to revolutionize several sectors of global urgency.

Gene 52
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Q&A: A decade on, what’s next for CAR-T therapies?

Pharmaceutical Technology

More broadly however, several advancements are on the horizon for cell and gene therapies in 2023. This includes the first potential approval of a CRISPR-based gene therapy called exa-cel , which is developed by CRISPR Therapeutics and Vertex Pharmaceuticals. AZ: Cell and gene therapies often come with a high price.

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Regeneron, AZ team up on drugs for obesity “superpower” gene

pharmaphorum

AstraZeneca has formed a partnership with Regeneron to investigate the potential of treating obesity using drugs directed at GPR75, a protective gene identified by scientists at the Regeneron Genetics Centre. The post Regeneron, AZ team up on drugs for obesity “superpower” gene appeared first on.

Gene 52
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Interview with Dr. Kristin Yarema, President of Cell Therapy at Poseida Therapeutics – Xtalks Life Science Podcast Ep. 129

XTalks

Poseida is a clinical-stage biopharmaceutical firm that utilizes its unique non-viral gene engineering methods to develop innovative cell and gene therapies. Scientists working at Poseida Therapeutics. Photo courtesy of Poseida Therapeutics.

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Could Fluoride be the Solution to Antibiotic Resistance? A New Study Weighs In

The Pharma Data

But scientists at the University of California (UC), Santa Barbara, believe fluoride may offer hope in the fight against antibiotic-resistant bacteria. Justin is replacing that with the gene for these fluoride exporters.” ” The use of low-concentration fluoride costs only about four cents per liter. ” Source link.

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A history of blood cancer treatment

pharmaphorum

During this period, Nobel prize-winning German scientist Paul Ehrlich developed his lock-key hypothesis of molecules that specifically bind to cell receptors. Building on the success of cytokine-based immunotherapies, scientists continued to seek other areas where the immune system could be leveraged against tumours.

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Bacteriophage Therapy: A Promising Solution to Antibiotic Resistance

Advarra

These resistance genes are commonly found on small circles of DNA called plasmids. They often carry genes to help the bacteria succeed by giving it a selective advantage, such as bacterial toxins or antibiotic resistance genes. The progeny viruses are released into the environment to await another host to infect.