Scienmag

DECEMBER 9, 2021

Credit: SWOG/The Hope Foundation In an analysis of data from postmenopausal patients with hormone receptor-positive breast cancer, a standard measure of gene expression known as the sensitivity-to-endocrine-therapy (SET2,3) index was found to have prognostic value that complemented the known prognostic value of the 21-gene breast recurrence score.

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Scienmag

AUGUST 11, 2020

New study identifies frequency of hormone therapy use and predictors of its use in women who underwent preventive oophorectomy as a result of carrying the BRCA gene CLEVELAND, Ohio (August 12, 2020)–Removal of the ovaries before natural menopause (surgical menopause) often exacerbates menopause symptoms and places women at increased risk for (..)

Hormones 43

Hormones Gene Cardiology Medicine 43

Medical Xpress

APRIL 17, 2023

Discovery of a gene in multiple mammalian species could pave the way for a highly effective, reversible and non-hormonal male contraceptive for humans and animals.

Genetics 75

Genetics Hormones Gene Research 75

Scienmag

SEPTEMBER 24, 2021

A new study delves into the evolution and function of the human growth hormone receptor gene, and asks what forces in humanity’s past may have driven changes to this vital piece of DNA. BUFFALO, N.Y. — Credit: Credit: Rebecca Farnham / Marie Saitou / University at Buffalo.

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Gene Scientist Genome Genomics 52

XTalks

JANUARY 9, 2024

The thyroid plays a critical role in the body by producing hormones that regulate metabolism, heart rate and body temperature among others. Types of Thyroid Conditions There are several different thyroid conditions, with each affecting thyroid hormone production or the gland’s structure, leading to a range of health issues.

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Hormones Antibody Trials Production 105

Medical Xpress

DECEMBER 6, 2022

Non-Hispanic Black women with hormone receptor (HR)-positive/HER2-negative, lymph node-positive breast cancer had worse outcomes compared to non-Hispanic whites, Asians, and Hispanics, despite similar 21-gene recurrence scores, according to a study presented at the 2022 San Antonio Breast Cancer Symposium, held December 6-10, 2022.

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HR Hormones Genetics Gene 74

Medical Xpress

DECEMBER 12, 2022

Ana Guadaño at the Alberto Sols Biomedical Research Institute (IIBM, a combined CSIC-UAM center) and involving the Complutense University of Madrid (UCM), used CRISPR gene editing techniques to incorporate into mice a mutation of the MCT8 protein responsible for transporting thyroid hormones to the interior of the cell.

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Gene Editing Genetics Hormones Medicine 75

XTalks

OCTOBER 18, 2024

The US Food and Drug Administration (FDA) has approved Itovebi (inavolisib) for the treatment of adults with hormone receptor-positive (HR-positive), human epidermal growth factor receptor 2 (HER2)-negative, locally advanced or metastatic breast cancer with a PIK3CA mutation.

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Trialfacts

MAY 27, 2024

This study will use brain imaging, genetics, questionnaires, and other assessments to map the brain systems and genes that underlie risk and resilience for mental health problems. Click Here to Check Your Eligibility for this Study The post Get Involved in Understanding Your Brain and Genes appeared first on Trialfacts.

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Gene Hormones Research Doctor 52

pharmaphorum

AUGUST 16, 2022

The study – which included an all-comer population of men with mCRPC – showed that Lynparza plus Johnson & Johnson’s hormonal therapy Zytiga (abiraterone) reduced the risk of disease progression or death by 34% versus Zytiga alone, with radiographic progression-free survival (rPFS) of 24.8 months and 16.6 months, respectively.

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Hormones Gene Sales Trials 111

Scienmag

FEBRUARY 12, 2021

Among the markers now in use are genes, proteins, hormones, lipids and other classes of molecules. Biomarkers play a central role in the diagnosis of disease and assessment of its course. Biomarkers can be found in the blood, in cerebrospinal fluid, urine and various types of tissues, but most of them have one thing in […].

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Hormones Protein Gene 68

Trialfacts

MAY 27, 2024

Click Here to Check Your Eligibility for this Study The post Discover How the Brain and Genes Affect The Mind appeared first on Trialfacts. If eligible, a member of the research team will contact you to discuss the study and answer any questions you may have.

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Gene Hormones Research Doctor 52

Scienmag

APRIL 9, 2021

Researchers at Osaka University define the complex role of SLPI, a secretory leukocyte protease inhibitor, in coordinating the biphasic action of parathyroid hormone on the metabolism of bone Credit: Osaka University Osaka, Japan – Despite what some people think, bone is not merely a passive component of the body.

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Hormones Research Gene Medicine 96

pharmaphorum

JULY 28, 2022

Alnylam Pharma has made a name for itself, developing gene-silencing therapies for rare disorders, but its latest discovery could take it into a much larger category – metabolic and cardiovascular disease. Transgenic mice in which the gene has been deleted have improved control of blood glucose and insulin sensitivity.

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Biobanking Gene Gene Silencing Drugs 52

Roots Analysis

AUGUST 31, 2023

Overview of Gene Switch The notion that genes might be turned on and off was discovered several decades ago when studies revealed that E. Gene switches are sites on genes where regulatory molecules can bind to trigger transcription process, leading to expression of a particular gene.

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Gene Gene Therapy Gene Expression Regulation 40

Pharmaceutical Technology

APRIL 19, 2023

In 2012, Bayer entered a five-year, multi-target collaboration with Evotec which yielded six non-hormonal pre-clinical candidates, two of which advanced to Phase I development: BAY2328065 and BAY2395840.

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Gene Therapy Hormones Production Sales 130

XTalks

MAY 17, 2023

While the exact physiology of vasomotor symptoms is not fully understood, it is believed that the significant fluctuations in reproductive hormones play a role in triggering these symptoms. Hormone replacement therapy is thought to be one of the most effective treatments for vasomotor symptoms.

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Hormones FDA Approval Drugs Clinical Trials 95

Worldwide Clinical Trials

JULY 8, 2024

Genetic Factors : Certain genetic mutations, such as those in DNA repair genes, can affect how cells respond to radiation. Individuals with familial cancer syndrome may have inherited mutations that predispose them to cancer development, affecting genes involved in DNA repair and cell cycle regulation.

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Hormones Regulation Clinical Trials Clinical Trials 130

XTalks

JANUARY 24, 2022

In developing the vegan casein, Fooditive aims to eradicate the downsides of factory farming, antibiotics, hormones and lactose. And while cow’s milk is a good source of protein and calcium, other ingredients and additives , like natural growth hormones and lactose, can make it hard to digest.

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Gene Splicing Protein Hormones Production 112

XTalks

NOVEMBER 26, 2020

In addition to innovative new antibody drugs and mRNA vaccines, researchers have found that the sleep-regulating hormone melatonin may also offer protection against COVID-19. The study was published in the journal PLOS Biology. Related: Can Vitamin D Be Beneficial for COVID-19 Patients?

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XTalks

MARCH 7, 2024

In this episode of the Xtalks Food Podcast, Sydney talks about gene edited foods and how this landmark guidance aims to demystify the FDA’s risk-based approach towards both genome edited foods and all new plant varieties. Genome editing stands as a cutting-edge technique that ingeniously introduces new traits into plants.

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Gene Editing Gene Genome Genomics 52

pharmaphorum

MARCH 8, 2021

The cost-effectiveness agency is assessing use of Lynparza (olaparib) in patients with tumours that carry BRCA1 or BRCA2 mutations who have previously been treated with the hormone therapies abiraterone and enzalutamide but have relapsed.

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Hormones Marketing Trials DNA 98

XTalks

MARCH 7, 2024

Optimizing Sleep During Perimenopause and Beyond Sleep plays a crucial role in overall health, particularly for midlife women transitioning into menopause, a phase marked by perimenopause where hormonal changes can severely disrupt sleep due to symptoms like nocturnal hot flashes.

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Genetics Hormones Genome Genomics 115

The Pharma Data

OCTOBER 21, 2020

21, 2020 — Low levels of thyroid hormone during pregnancy may contribute to the development of attention deficit hyperactivity disorder in the child, new research suggests. Thyroid hormones play an important role in the growth and development of the fetal brain, especially during the first trimester of pregnancy, the researchers said.

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Hormones Gene Research Medicine 52

Scienmag

DECEMBER 8, 2020

In an article published in the Journal of Pineal Research, researchers at São Paulo State University and collaborators describe a set of genes potentially regulated by the ‘sleep hormone’ in some types of tumor A Brazilian study published in the Journal of Pineal Research describes a group of genes potentially regulated by the hormone melatonin (..)

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Hormones Gene Regulation Research 40

Scienmag

MARCH 11, 2021

During pregnancy, the hormone progesterone helps to […]. The study in mice — published online in the Proceedings of the National Academy of Sciences — provides novel insights for developing treatments.

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Hormones Development Research Gene 74

pharmaphorum

JULY 14, 2022

Piqray (alpelisib) meanwhile is a once-daily, oral PI3K inhibitor that has been cleared for use in combination with hormonal therapy (fulvestrant) for hormone receptor-positive, HER2-negative, PIK3CA-mutated locally advanced or metastatic breast cancer, that has progressed after endocrine and CDK4/6 inhibitor therapy.

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Drugs Hormones Genome Genomics 104

XTalks

SEPTEMBER 17, 2020

Symptoms and Etiology: Caused by an overproduction of growth hormone, acromegaly primarily affects adults. By reducing the amount of growth hormone in the blood, progressive enlargement of bones should be slowed. By reducing the amount of growth hormone in the blood, progressive enlargement of bones should be slowed.

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Trials Gene Hormones Clinical Trials 98

The Pharma Data

NOVEMBER 24, 2020

25, 2020 /CNW/ – On August 21, 2020 , Health Canada approved Lynparza® (olaparib), for the treatment of adult patients with deleterious or suspected deleterious germline and/or somatic BRCA or ATM- mutated metastatic castration-resistant prostate cancer (mCRPC) who have progressed following prior treatment with a new hormonal agent (NHA).

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Gene Hormones DNA Medicine 52

XTalks

MAY 27, 2022

Treatment resistance has been in part attributed to mutation in the ESR1 gene which plays a significant role in sexual and reproductive health. The ESR1 gene has also been detected in recurrent local and metastatic cancer cells. which is encoded by the ESR1 gene in humans. What is Elacestrant and How Does It Work? Future Scope.

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Clinical Trials Clinical Trials Trials Gene 98

Drug Discovery Today

FEBRUARY 13, 2020

Experts in the emotional needs of small children say increased levels of the stress hormone cortisol in babies and small children who are separated from their parents, especially their mothers, could have a long-term genetic impact on future generations.

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Gene Hormones Genetics Medicine 40

Pharma Packaging Solutions

JUNE 30, 2023

Hormones (such as insulin, glucagon, and growth hormone, to name a few) are produced by recombinant DNA, as are blood factors, thrombolytic agents, interferons, monoclonal antibodies, therapeutic enzymes, and more.

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Recombinant DNA Technology Packaging Packaging Gene Therapy 52

Scienmag

DECEMBER 7, 2020

University of Pennsylvania biologists have uncovered one way plants respond to hormonal cues. A similar process is likely at play in mammals. Just like other organisms, plants must respond dynamically to a variety of cues over their lifetime.

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Hormones Gene Genetics Medicine 63

Roots Analysis

SEPTEMBER 9, 2024

The main components of protein expression are a vector (plasmid) containing the gene of interest, and a host cell, for instance mammalian or prokaryotic cell. Protein expression process can be divided into following steps: Transcription: The DNA sequence of a gene is transcribed into mRNA.

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Protein Gene Production DNA 40

XTalks

MARCH 13, 2024

Hormone-based therapeutics aim to delay glaucoma progression by enhancing estrogen’s potential protective effects. There are also studies examining gene therapy-based techniques to repair or replace genetic defects contributing to this disease.

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Gene Therapy Gene Life Science DNA 111

pharmaphorum

JANUARY 16, 2023

Hormone replacement therapy (HRT) could cut the risk of Alzheimer’s in some women at elevated risk of the disease, according to researchers in the UK.

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Hormones Genotype Research Genetics 75

The Pharma Data

DECEMBER 9, 2020

The trial, conducted in nine countries, found that adding chemotherapy to hormone-blocking drugs brought no added benefit to a particular group of patients. Those were postmenopausal women with hormone-sensitive breast cancer that had spread to only one to three lymph nodes, and who had a low risk of recurrence. WEDNESDAY, Dec.

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Hormones Trials Medicine Research 52