STAT News

OCTOBER 6, 2022

Bluebird also recently said it would charge $3 million for Skysona, the gene therapy it just launched for a rare brain-wasting disease.  Even a drug-price watchdog, the Institute for Clinical and Economic Review, deemed the $2.8 Continue to STAT+ to read the full story…

Gene Therapy 98

Gene Therapy Gene Insulin Drugs 98

Pharmaceutical Technology

JUNE 29, 2022

The next wave of medicine is well on course to be cell and gene-based. For cell and gene therapy applications, you need a variety of speciality enzymes of the highest purity, specificity, and consistency. Meanwhile, the pharma industry is undergoing somewhat of a transformation itself. Developing best-in-class speciality enzymes.

Drugs 295

Drugs Gene Therapy Production Manufacturing 295

Scienmag

JUNE 7, 2021

Credit: ETH Zurich Many modern fitness trackers and smartwatches feature integrated LEDs. The green light emitted, whether continuous or pulsed, penetrates the skin and can be used to measure the wearer’s heart rate during physical activity or while at rest. These watches have become extremely popular.

Insulin 95

Insulin Production Research Gene Therapy 95

Scienmag

MAY 17, 2022

These small, circular DNA molecules are used by scientists to introduce new genes into a target organism. Well known for their applications in the production of therapeutic proteins like insulin, plasmids are broadly used in the large-scale production of many bioproducts. Plasmids have extensive use in basic and applied biology.

Production 90

Production Insulin Development DNA 90

Scienmag

JANUARY 26, 2021

publishers New Rochelle, NY, January 26, 2021–Hybrid closed-loop insulin therapy improved glycemic control in adolescents and young adults with type 1 diabetes. Credit: Mary Ann Liebert, Inc.,

Insulin 55

Insulin Trials Gene Therapy Clinical Trials 55

Pharmaceutical Technology

FEBRUARY 16, 2023

DNA/histone methylation governs what genes are repressed or expressed. Despite such a broad range of pathologies, the commonality between them is the insulin response. dietary restriction) of the evolutionarily conserved insulin signalling pathway. dietary restriction) of the evolutionarily conserved insulin signalling pathway.

Insulin 130

Insulin DNA Genetics Life Science 130

Camargo

NOVEMBER 29, 2021

Gene and cellular therapies. They may contain proteins that control the action of other proteins and cellular processes, genes that control production of vital proteins, modified human hormones, or cells that produce substances that suppress or activate components of the immune system. Blood and blood components. Allergenics.

Development 180

Development Protein Production Hormones 180

pharmaphorum

MARCH 11, 2021

The therapy takes the form of stem cell-derived human pancreatic islet cells, which secrete insulin in the body in response to rising blood glucose. If VX-880 works, it could remove or reduce the reliance of patients with the disease on insulin injections. We have never been in more disease areas than we are right now.

Gene Editing 98

Gene Editing Insulin Immune Response Gene 98

pharmaphorum

AUGUST 24, 2021

Vertex Pharma has ramped up its involvement in gene-editing medicines for the third time in a matter of months, agreeing a partnership with CRISPR specialist Arbor Biotechnologies that could be worth up to $1.2 If approved, it could mount a challenge to bluebird bio’s gene therapy Zynteglo, which is already approved in Europe.

Gene Editing 52

Gene Editing Gene In-Vivo Genetics 52

Scienmag

OCTOBER 29, 2020

USF Health-led TEDDY analysis focuses on development of multiple distinct autoantibodies targeting insulin-producing cells, from initial autoimmunity to symptomatic type 1 diabetes Credit: Courtesy of USF Health TAMPA, Fla.

Genetics 92

Genetics Insulin Development Clinical Trials 92

pharmaphorum

JULY 28, 2022

Alnylam Pharma has made a name for itself, developing gene-silencing therapies for rare disorders, but its latest discovery could take it into a much larger category – metabolic and cardiovascular disease. Transgenic mice in which the gene has been deleted have improved control of blood glucose and insulin sensitivity.

Biobanking 52

Biobanking Gene Gene Silencing Drugs 52

Scienmag

AUGUST 5, 2020

But when it does, it’s mostly due to a mutation in a single gene such as the KCNJ11 or insulin (INS). Credit: Tokyo Tech Diabetes seldom occurs in newborns–a condition known as neonatal diabetes.

Insulin 53

Insulin Gene Research Genetics 53

XTalks

JANUARY 21, 2025

Companion diagnostic for Pfizers hemophilia B gene therapy Beqvez (idanacogene elaparvovec-dzkt). The test is designed for identifying individuals with moderate to severe hemophilia B (congenital factor IX [FIX] deficiency) who may benefit from the gene therapy Beqvez. The diagnostic tests for more than 500 genes to profile tumors.

FDA Approval 105

FDA Approval Manufacturing Development RNA 105

Pharmaceutical Technology

DECEMBER 22, 2022

Finally there was also the completion of a deal for Biohaven Pharmaceuticals, which adds a calcitonin gene-related peptide portfolio, including NURTEC® ODT, to the company’s portfolio. It was also announced that the organisation would enter into collaboration with the Juvenile Diabetes Research Foundation (JDRF). Civica JAAQ Sanofi.

Insulin 130

Insulin Production Development Genetics 130

The Pharma Data

MARCH 3, 2022

Patients taking the oral blood pressure medication not only required less daily insulin two years after first diagnosis of the disease, but also showed evidence of surprising immunomodulatory benefits. Type 1 diabetes is an autoimmune disease that causes loss of pancreatic beta cells, which produce endogenous insulin.

Insulin 52

Insulin Gene Expression Gene Protein 52

Delveinsight

DECEMBER 10, 2020

The body’s immune system falsely attacks insulin-making beta cells in the pancreas in Type 1 diabetes. OCA-B, or B cell-specific Oct1/2 coactivator, binds to and controls about 150 genes involved in a process through which T cells are reactivated upon reencountering antigens they have earlier identified and memorised.

Gene Therapy 52

Gene Therapy Gene Vaccination Vaccine 52

BioPharma Reporter

JUNE 25, 2024

Results from a phase 1/2 clinical trial revealed that PolTREGâs regulatory T cell (Treg) therapy, PTG-007, was able to restore insulin secretion in children with type-1 diabetes.

Insulin 52

Insulin Clinical Trials Clinical Trials Trials 52

BioSpace

NOVEMBER 17, 2022

Editas Medicine is pausing its ocular gene therapy program after demonstrating a favorable safety profile and seeking a potential partner to develop EDIT-101, the company announced Thursday.

Gene Therapy 42

Gene Therapy Gene Gene Editing Medicine 42

Roots Analysis

SEPTEMBER 9, 2024

The main components of protein expression are a vector (plasmid) containing the gene of interest, and a host cell, for instance mammalian or prokaryotic cell. Protein expression process can be divided into following steps: Transcription: The DNA sequence of a gene is transcribed into mRNA.

Protein 40

Protein Gene Production DNA 40

XTalks

FEBRUARY 6, 2024

Revita, an outpatient endoscopic procedural therapy, which aims to eliminate insulin needs and enhance glycemic control by ablating dysfunctional duodenal mucosa. In a recent development, Fractyl Health announced the selection of RJVA-001 as its inaugural clinical T2D candidate in the Rejuva gene therapy platform.

Gene Therapy 98

Gene Therapy Gene Clinical Trials Clinical Trials 98

Delveinsight

FEBRUARY 10, 2021

Progeria is an autosomal dominant disorder caused by the mutation in the lamin A (LMNA) gene. LMNA gene-related HGPS is caused by a single mutation in the LMNA gene in exon 11. LMNA gene causes HGPS due to the production of an abnormal lamin A protein. What is the cause of progeria?

Gene 97

Gene Genetics Insulin Production 97

Pharma Packaging Solutions

JUNE 30, 2023

Hormones (such as insulin, glucagon, and growth hormone, to name a few) are produced by recombinant DNA, as are blood factors, thrombolytic agents, interferons, monoclonal antibodies, therapeutic enzymes, and more.

Recombinant DNA Technology 52

Recombinant DNA Technology Packaging Packaging Gene Therapy 52

Pharmaceutical Technology

JANUARY 31, 2023

While insulin price caps will begin this year, larger effects will be delayed until 2026 – when the US federal government will be allowed to negotiate Medicare prices and demand rebates from drug companies that price gouge. It’s much needed. It’s a hot area.”

Drugs 130

Drugs Gene Therapy Regulation Insulin 130

The Pharma Data

JANUARY 21, 2021

Both of those factors had weaker associations with heart disease onset in women younger than 55 than lipoprotein insulin resistance (LPIR,) a newer metric for insulin resistance. Insulin resistance occurs when cells in muscles, fat and the liver don’t respond well to insulin and can’t use glucose.

Insulin 52

Insulin Cardiology Research Doctors 52

XTalks

SEPTEMBER 17, 2020

Acromegaly Surrogate Endpoint: Serum growth hormone and serum insulin-like growth factor 1 (IGF-1) are acceptable surrogate endpoints for acromegaly clinical trials involving somatostatin analogs such as octreotide, lanreotide and pasireotide. Mutations in the gene encoding ?-Gal Prevalence: ABCG5 gene mutation: 1 in 2.6

Trials 98

Trials Gene Hormones Clinical Trials 98

The Pharma Data

JULY 28, 2021

Individuals with at least one inactive copy of the GPR75 gene had lower body mass index (BMI) and, on average, tended to weigh about 12 pounds less and faced a 54% lower risk of obesity than those without the mutation. 1 Strong associations were also seen with improvements in diabetes parameters, including glucose lowering. Yancopoulos, M.D.,

Medicine 52

Medicine Development Research Insulin 52

XTalks

JULY 27, 2022

Dr. Toleikis spoke about the latest clinical trial data for the medical device, and also about the company’s new partnership with Evotec to integrate its insulin-producing cells in the Cell Pouch System. Toleikis about Sernova’s proprietary Cell Pouch System that is designed to house therapeutic cells.

Life Science 52

Life Science Insulin Clinical Trials Clinical Trials 52

XTalks

AUGUST 30, 2024

These breakthroughs, combined with the growing focus on gene therapy, oncology and immunology, have brought these companies to the forefront of global healthcare. The recent partnership to produce affordable insulin in Africa aims to reach over four million people by 2026, reflecting Novo Nordisk’s commitment to global health equity.

Marketing 98

Marketing Production Sales Antibody 98

Delveinsight

AUGUST 20, 2020

FDA rejects BioMarin’s gene therapy and Gilead’s filgotinib over concerns. The FDA refused to approve BioMarin’s hemophilia A gene therapy valoctocogene roxaparvovec. The removal of an AdComm was seen as a positive. Immune-evading cells with PD-L1 control diabetes in mice.

Gene Therapy 52

Gene Therapy Research Gene Antibody 52

pharmaphorum

JANUARY 10, 2023

The one-shot therapy is expected to provide long-lasting effects, reduce the number of bleeds experienced by patients, and reduce the need Factor VIII replacement therapy.

Drugs 52

Drugs Gene Therapy Antibody Insulin 52

The Pharma Data

NOVEMBER 2, 2020

On average, people started eating fewer calories after a week, and saw their “good” HDL cholesterol increase while their levels of “bad” LDL cholesterol, insulin and triglycerides all fell. Experts called the findings “interesting,” but stressed the work is very preliminary.

Antibody 52

Antibody Drugs Hormones Insulin 52

Roots Analysis

JANUARY 14, 2024

Usually, the desired gene, such as human insulin gene, when inserted into the plasmid of the host cell uses transcriptional and translational machinery of the host to express itself. It is worth mentioning that in vitro gene expression requires a suitable host for the production of a specific gene product.

Contract Manufacturing 40

Contract Manufacturing Protein Manufacturing Production 40

XTalks

AUGUST 2, 2023

Meanwhile, BioMarin’s gene therapy Roctavian is approved by the FDA for the treatment of hemophilia A. It is a dipeptidyl peptidase-4 inhibitor that keeps insulin levels stable and reduces the amount of glucose produced by the body. But all three drugs have new competitors. Both are anti-CD20 agents. billion in 2022. billion ($8.72

Sales 98

Sales Manufacturing FDA Approval Life Science 98

Roots Analysis

SEPTEMBER 22, 2023

Diabetes : These devices offer an effective solution for delivering insulin, improving glycemic control, and enhancing the quality of life for diabetic patients. The historical trends of existing delivery devices, such as prefilled syringes, autoinjectors and insulin pumps, suggest a strong demand in the market.

Drug Delivery 40

Drug Delivery Marketing Insulin Drugs 40

The Pharma Data

MAY 13, 2021

food is “A food in which the gene from one species has been forced into the DNA of another species and the process itself creates all sorts of unpredicted side effects.”. This is the fattest and sickest we have ever been in the history of the world. A better definition of a G.M.O. When lab rats were given G.M.O.

Production 52

Production Containment Genetics Doctors 52

The Pharma Data

MAY 15, 2021

So you can see that your genes haven’t had time to adapt to the embarrassing over-abundance of food that you have today. Your body can’t burn fat when your insulin is high. During the Eat Stop Eat protocol your Insulin Levels will drop to one third of regular levels allowing you to burn fat at an extreme pace.

Production 52

Production Hormones Protein Insulin 52

pharmaphorum

SEPTEMBER 1, 2020

The first was insulin – Frederick Banting and colleagues managed to isolate insulin that could treat diabetes, up until that point a fatal condition. The period between 1918 and 1939 was marked by two breakthroughs that presaged the arrival of the pharma industry as we know it today.

Medicine 145

Medicine Insulin Drugs Pharmacy 145