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These models are engrafted with mouse tumors derived from the same strain background; this genetic similarity between tumor and host prevents the host from rejecting the tumor. One consideration in using syngeneic models is that some drug candidates can cause a negative immuneresponse not seen in humans.
Both vaccine candidates incorporate Novavax’ proprietary saponin-based Matrix-M adjuvant in order to enhance the immuneresponse and stimulate high levels of neutralizing antibodies.
Both vaccine candidates incorporate Novavax’ proprietary saponin-based Matrix-M adjuvant in order to enhance the immuneresponse and stimulate high levels of neutralizing antibodies.
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