Ocuphire and Opus Genetics merge to develop IRD gene therapy
Pharmaceutical Technology
OCTOBER 23, 2024
Ocuphire Pharma has announced the acquisition of Opus Genetics to develop gene therapies for inherited retinal diseases (IRDs).
Genetics Related Topics 
Leveraging Genetic Testing for Enrolling Rare Disease Trials
Worldwide Clinical Trials
JANUARY 24, 2024
Written By: Derek Ansel, MS, CCRA, Executive Director, Therapeutic Strategy Lead, Rare Disease Given that 80% of rare diseases have a genetic etiology, genetic implications should be addressed at the onset of a clinical program to support trial enrollment. One diagnostic example that I discussed in my presentation is autism.
Genetics 
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BridgeBio secures $1.25bn for genetic therapy development
Pharmaceutical Technology
JANUARY 19, 2024
BridgeBio Pharma has secured strategic financing of $1.25bn from Blue Owl Capital and CPP Investments for genetic therapies.
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Biology opens up new frontiers in medicine to cure genetic diseases: Kiran Mazumdar Shaw
AuroBlog - Aurous Healthcare Clinical Trials blog
SEPTEMBER 17, 2024
We are witnessing a revolution in healthcare, driven by advances in genetics, Omics, RNA and CRISPR gene-editing technology, to deliver precision and personalised medicine, said Kiran Mazumdar-Shaw, executive chairperson, Biocon and Biocon Biologics. This holds the potential to cure genetic diseases that have plagued families for generations.
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Scribe and Sanofi expand genetic therapy development deal
Pharmaceutical Technology
JULY 18, 2023
Scribe Therapeutics and Sanofi have expanded partnership to progress the development of in vivo genetic therapies to treat genomic diseases.
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Genetic diagnostics promises paradigm shift towards personalized, proactive healthcare
AuroBlog - Aurous Healthcare Clinical Trials blog
FEBRUARY 18, 2024
Indian healthcare industry is of the view that emergence of genetic diagnostics will be a paradigm shift towards personalized medicine. Through the ever-evolving landscape of healthcare, the role of genetic diagnostics offers personalized insights and proactive solutions for disease management and prevention.
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Pelican and Primordial Genetics merge to form biotech company Primrose Bio
Pharmaceutical Technology
SEPTEMBER 19, 2023
Pelican Technology has combined business with Primordial Genetics under a deal to create a private biotechnology company Primrose Bio.
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Cure Genetics and Frametact seek gene cures for neurological ailments
Pharmaceutical Technology
SEPTEMBER 15, 2023
Cure Genetics has entered a partnership and licensing deal with Frametact to develop gene therapy for familial neurological ailments.
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A Healthy Lifestyle Could Offset Genetic Risk For Early Death by a Hopeful 62%
AuroBlog - Aurous Healthcare Clinical Trials blog
MAY 7, 2024
When research tells us that our grandparents’ diets can affect our health decades later, it can be hard to shake the feeling that genetics spells out the trajectory of our wellbeing. But how much of our health is actually determined by our genes, and what effect does our lifestyle have, for better or worse? Can […]
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Scientists Discover a Genetic Variant That Seems to Limit HIV Infection
AuroBlog - Aurous Healthcare Clinical Trials blog
AUGUST 13, 2023
Now an international team of researchers has discovered a new genetic variant in people of African ancestries that appears to restrict HIV replication after an infection sets in. A tiny fraction of people are naturally resistant to HIV infections, and scientists want to understand why.
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FDA clears AstraZeneca, Merck drug to treat some genetic breast cancers early
Bio Pharma Dive
MARCH 14, 2022
Lynparza is the first drug targeting BRCA mutations to be approved for use in early breast cancer, a decision that could lead to more genetic testing.
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Synlogic gets grant for genetically engineered bacteria for attenuating metabolic diseases
Pharmaceutical Technology
APRIL 22, 2024
Discover how Synlogic Inc's patented genetically engineered bacteria produce short-chain fatty acids to combat metabolic diseases. Learn more about this innovative treatment approach.
Harnessing genetics to propel cancer research and clinical success
pharmaphorum
AUGUST 6, 2024
Discover how Step Pharma is harnessing genetics and developing therapeutics targeting CTPS1 to advance cancer research and enhance clinical success. Learn more about their innovative approach.
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Synlogic gets grant for genetically engineered bacteria for treating phenylketonuria
Pharmaceutical Technology
MARCH 28, 2024
Discover how Synlogic Inc's patented genetically programmed microorganisms can modulate and treat diseases. Learn about the innovative method for producing pharmaceutical compositions using non-pathogenic bacteria to metabolize phenylalanine. Explore the potential applications in gut microbiome and tumor environments.
Lilly and ProQR to expand genetic medicine development agreement
Pharmaceutical Technology
DECEMBER 23, 2022
Eli Lilly and Company has expanded a licencing and partnership agreement with ProQR Therapeutics to discover, develop and market new genetic medicines. The post Lilly and ProQR to expand genetic medicine development agreement appeared first on Pharmaceutical Technology.
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Mirai Bio launches with plan to help genetic med developers
pharmaphorum
SEPTEMBER 26, 2024
Flagship Pioneering's latest biotech launch, Mirai Bio, aims to help genetic medicine developers find the best way to get their drugs to patients.The new Cambridge, Massachusetts-based company – which was set up in 2021 but makes its official launch today with $50 million in funding from Flagship – applies artificial intelligence to solve the various (..)
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Yield10 Bioscience gets grant for genetically engineered oilseed plant expressing plant protein
Pharmaceutical Technology
MARCH 29, 2024
Discover the groundbreaking patent by Yield10 Bioscience Inc for a genetically engineered oilseed plant expressing a plant protein, revolutionizing biotechnology in agriculture.
1910 Genetics and Microsoft partner to enhance pharmaceutical R&D
Pharmaceutical Technology
MARCH 1, 2024
1910 Genetics has entered an agreement with Microsoft, aiming to revitalise pharmaceutical research and development (R&D) productivity.
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AbCellera Biologics gets grant for enhanced production of diverse antibodies using genetically modified mice
Pharmaceutical Technology
APRIL 22, 2024
Enhance immunoglobulin diversity with AbCellera's patented method for isolating B cells from genetically modified mice. Discover a broader repertoire of antibodies with a recently granted patent.
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Study reveals genetic variants are more common in Parkinson’s disease patients
Pharma Times
AUGUST 9, 2024
The study revealed that 13% of patients have a genetic form of the neurological disease
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123 Indian healthcare looks at pharmacogenomics in patient care as comprehensive genetic tests gain ground
AuroBlog - Aurous Healthcare Clinical Trials blog
NOVEMBER 14, 2023
Indian healthcare looks at pharmacogenomics, the study of influence of genetic factors on drug response, in patient care as comprehensive genetic tests gain ground.
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Merck pays Seattle Genetics $1.7B as antibody cancer drugs continue comeback
Bio Pharma Dive
SEPTEMBER 14, 2020
Merck's deal for Seattle Genetics' antibody-drug conjugate comes as Gilead agreed to acquire rival developer Immunomedics in the biotech industry's largest buyout of 2020.
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Fulgent Genetics acquires therapeutics development company Fulgent Pharma
Pharmaceutical Technology
NOVEMBER 8, 2022
Fulgent Genetics has acquired clinical-stage therapeutics development firm Fulgent Pharma for a total deal price of nearly $100m. According to the deal, the purchase price, contingent on adjustments, has to be paid by Fulgent Genetics as a combination of cash on hand and its shares of common stock.
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Interferon alfa-2b by Center for Genetic Engineering and Biotechnology for Genital Warts (Condylomata Acuminata): Likelihood of Approval
Pharmaceutical Technology
SEPTEMBER 8, 2024
Interferon alfa-2b is under clinical development by Center for Genetic Engineering and Biotechnology and currently in Phase II for Genital Warts (Condylomata Acuminata).
AI startup Basecamp allies with the Broad to dream up ‘programmable’ genetic medicines
Bio Pharma Dive
OCTOBER 9, 2024
The company, which is building a database of biological interactions found in nature, revealed $60 million in funding and a collaboration with David Liu’s lab.
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A new startup gets Takeda's backing to take complex genetic medicines 'off the shelf'
Bio Pharma Dive
FEBRUARY 11, 2021
Ensoma Therapeutics debuts with a lucrative alliance with the Japanese pharma and an unusual way to deliver genetic medicines into the body.
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Moderna and Generation Bio partner for genetic medicines development
Pharmaceutical Technology
MARCH 24, 2023
Moderna has entered a strategic partnership with Generation Bio for the development of non-viral genetic medicines. Moderna’s biological and technical expertise will be combined with core technologies of the non-viral genetic medicine platform from Generation Bio.
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SOPHiA GENETICS and AstraZeneca partner for oncology drugs development
Pharmaceutical Technology
FEBRUARY 13, 2023
SOPHiA GENETICS is expanding its collaboration with AstraZeneca to include multimodal approaches for developing cancer drugs. This collaboration aims to use the global SOPHiA DDM platform, a cloud-native platform of SOPHiA GENETICS, and multimodal algorithmic capabilities for AstraZeneca’s oncology portfolio.
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We’ve Discovered A Subtle Genetic Imbalance That May Drive Aging
AuroBlog - Aurous Healthcare Clinical Trials blog
DECEMBER 21, 2022
Scientists have found an extremely subtle twist in the genetics of aging cells, one that seems to make them increasingly less functional as time goes on.
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Leading innovators in genetically modified animal models for the pharmaceutical industry
Pharmaceutical Technology
FEBRUARY 15, 2023
In the last three years alone, there have been over 633,000 patents filed and granted in the pharmaceutical industry, according to GlobalData’s report on Innovation in Pharmaceuticals: Genetically modified animal models. Regeneron Pharmaceuticals is one of the leading patent filers in the generation of genetically modified animal models.
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Leading innovators in transcription factors for genetically modified cells for the pharmaceutical industry
Pharmaceutical Technology
JUNE 4, 2023
In the last three years alone, there have been over 633,000 patents filed and granted in the pharmaceutical industry, according to GlobalData’s report on Innovation in Pharmaceuticals: Transcription factors for genetically modified cells. However, not all innovations are equal and nor do they follow a constant upward trend.
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To Share or Not to Share Failed Genetic Screening Results with Patients
Worldwide Clinical Trials
FEBRUARY 6, 2023
When using genetic screening to identify clinical trial volunteers, a sponsor’s obligations for further testing and disclosure of results to patients and families are unclear, especially when the results have no impact on medical management. Guidance in this area is much needed. Read the full article!
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UK agency pilots biobank to study links between genetics and drug side effects
Pharmaceutical Technology
MAY 25, 2023
The Medicines and Healthcare products Regulatory Agency (MHRA) aims to launch a pilot genetic biobank that will gather patient data to associate drug-related adverse events to their genetic makeup. The first patients will have their genetic makeup sequenced in Spring 2024 and this data will be shared in 2025.
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Exsilio debuts with $82M, pitching a ‘leap’ forward for genetic medicine
Bio Pharma Dive
JUNE 25, 2024
The company claims it can address some of the field’s limitations with medicines delivered via messenger RNA and lipid nanoparticles.
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Study finds genetic screening of adults would be cost-effective
Medical Xpress
MAY 8, 2023
An exhaustive cost-benefit analysis of population genetic testing published in Annals of Internal Medicine concludes with a recommendation to U.S. health policymakers to adopt routine testing of adults ages 40 and under for three genetic conditions posing high risk of life-threatening illness.
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Predictive genetic testing offers the greatest promise and ethical challenge of our time
pharmaphorum
DECEMBER 11, 2023
Predictive genetic testing offers the greatest promise and ethical challenge of our time Mike.Hammerton Mon, 11/12/2023 - 11:00 Bookmark this
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Genetically modified herpes combats advanced cancers
Pharma Times
SEPTEMBER 21, 2022
A new genetically engineered virus has delivered a one-two punch in initial phase 1 trial
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STAT+: Emerging class of genetically targeted drugs induce remissions in leukemia patients
STAT News
DECEMBER 10, 2022
NEW ORLEANS — An emerging class of genetically targeted drugs is inducing remissions in about one-third of patients with advanced leukemia, according to updates Saturday from separate clinical trials. Continue to STAT+ to read the full story…
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4th annual Rare & Genetic Kidney Disease Drug Development Summit
pharmaphorum
SEPTEMBER 3, 2024
Join the upcoming 4th Annual Rare & Genetic Kidney Disease Drug Development Summit organised by Hanson Wade to connect with industry experts, discuss cutting-edge research, and drive progress in the field of rare kidney diseases.
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Study identifies genetic mutations that contribute to adult epilepsy
Medical Xpress
MAY 1, 2023
The condition's origins and progression are not well understood, and it has been unclear if genetic mutations may contribute to TLE. Patients with this form of epilepsy may require neurosurgery to provide relief from seizures.
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Insights into causes of rare genetic immune disorders
Medical Xpress
MARCH 21, 2023
The cellular glitches underlying a rare genetic disorder called activated PI3K Delta syndrome 2 (APDS2) have been identified by researchers at the Garvan Institute of Medical Research. The disorder is caused by genetic variations that disrupt immune cell signaling through a protein called PI3K.
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Can genetic data be a magic bullet for drug R&D?
pharmaphorum
JANUARY 24, 2023
Ben Hargreaves finds that the vast amount of genetic data that exists today could help provide a faster, more targeted way of developing new drug candidates. The logical extension to this kind of approach is treating individual patients, with their individual genetic makeup.
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Offering genetic testing at the point of care may increase uptake
Medical Xpress
MAY 3, 2023
Genetic testing for hereditary cancers, such as breast, colon, pancreatic, and ovarian cancer, helps at-risk individuals understand their familial risk for these diseases and make informed decisions about next steps in care.
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