Scienmag

APRIL 15, 2021

Epigenetic regulator HPI1a drives de novo genome reorganization in early Drosophila embryos Credit: MPI of Immunobiology and Epigenetics, F. Instead, it is folded in a very organized way by the help of different proteins to establish a unique spatial organization of the genetic information. This […].

Genome 56

Genome Genomics DNA Genetics 56

pharmaphorum

OCTOBER 19, 2022

million ($40 million) first-round financing that will be used to explore so-called ‘dark’ regions of the human genome. Nucleome’s platform adds 3D genomic information to a wealth of available genomic data, uncovering a new dimension of information that is disease as well as cell type-specific.

Genome 59

Genome Genomics Gene Gene Expression 59

XTalks

FEBRUARY 21, 2025

Current Share Price: PWS is a complex, genetically determined neurodevelopmental disorder that affects multiple organ systems. And hyperphagia is common not only to PWS but also to hypothalamic obesity, binge-eating disorder and certain rare genetic disorders like Bardet-Biedl syndrome.

Genetics 59

Genetics Hormones Gene Expression Gene 59

Scienmag

MAY 7, 2021

The two meters of -stretched- DNA contained in human cells are continuously twisting and untwisting to give access to genetic information: when a gene is expressed to generate a protein, the two strands of DNA are separated to give access to all the machinery necessary for this expression, resulting in an excessive accumulation of coiling […]. (..)

DNA 62

DNA Regulation Genome Genomics 62

Scienmag

OCTOBER 27, 2021

The rapid scientific advancements that followed the mapping of the human genome have revealed just how staggeringly complex the world of genetics is. We now know that proteins are not just the products of genes, but that they also interact with genes, influencing and regulating the rhythm of their expression.

Gene 72

Gene Genomics Genome Genetics 72

XTalks

JULY 14, 2022

However, there is limited knowledge about the upstream regulators of most genes. CRISPR-Cas9 gene editing was used to simultaneously perturb thousands of genes by targeting specific points of genetic code. They found that many of the regulators controlled each other through numerous interconnected feedback loops.

Gene 98

Gene Regulation Protein Gene Editing 98

pharmaphorum

DECEMBER 21, 2021

In a recent webinar held by pharmaphorum, in partnership with IQVIA, a discussion was held looking at how to make academic and commercial medical research more efficient, while also looking at the opportunity of genomic data to bring benefits to patients and healthcare systems. The potential to leverage genomic data.

Development 98

Development Genome Genomics Drugs 98

XTalks

FEBRUARY 4, 2021

The power of leveraging clinical data to decipher disease mechanisms and fuel drug discovery has rapidly grown in the era of genomics and personalized medicine. Genuity Science focuses on population genomics as a tool to derive novel biological insights through partnerships with industry-leading pharmaceutical and biotech companies.

Research 98

Research Biobanking Drugs Genomics 98

The Pharma Data

AUGUST 28, 2020

FoundationOne Liquid CDx analyses more than 300 cancer-related genes and multiple genomic signatures to help inform treatment decisions for all solid tumour cancers. Many cancer patients are unable to have a tissue biopsy. Source link.

Genome 52

Genome Genomics Gene Regulation 52

FDA Law Blog

MARCH 3, 2024

The Act is intended to address national security concerns by prohibiting certain conduct by regulated industry. Biotechnology companies of concern include BGI (formerly Beijing Genomics Institute), MGI, Complete Genomics, WuXi Apptec, and any subsidiary, parent, affiliate, or successor of such entities.

Genomics 102

Genomics Genome Manufacturing Production 102

pharmaphorum

FEBRUARY 11, 2022

” Hopes were high that a drug developed by Sangamo based on its zinc finger nuclease (ZFN) genome-editing technology could lead to the first therapy that could correct the genetic defect n MPS I, but that candidate – called SB-318 – flunked out in a clinical trial reported in 2019 and was discontinued.

Gene Therapy 111

Gene Therapy Gene Trials FDA Approval 111

Scienmag

AUGUST 5, 2020

A long-running national collaboration has produced a comprehensive catalogue of the molecular elements that regulate our genes Credit: Ella Maru Studio A 17-year research project has generated a detailed atlas of the genome that reveals the location of hundreds of thousands of potential regulatory regions – a resource that will help all human (..)

Genomics 53

Genomics Genome Gene Regulation 53

Scienmag

NOVEMBER 16, 2020

Wnt-regulated lncRNA discovery enhanced by in vivo identification and CRISPRi functional validation. Genome Med 12, 89 (2020). Singapore scientists uncover potential role of long non-coding RNAs in pancreatic cancer Credit: From Figure 4 in Liu, S., Harmston, N., Glaser, T.L.

In-Vivo 53

In-Vivo RNA DNA Genomics 53

FDA Law Blog

MAY 25, 2022

Javitt — On April 19, FDA issued a safety communication regarding genetic non-invasive prenatal screening, commonly referred to as non-invasive prenatal tests or NIPT ( here ). NIPT are intended to screen for genetic abnormalities in a fetus. FDASLA incorporates a modified version of the VALID Act.

Regulation 40

Regulation Genetics In-Vitro Development 40

pharmaphorum

JANUARY 4, 2023

The proposed EHDS Regulation 1 ( Proposal ), introduced in May 2022 by the European Commission (EC), aims to reform the “situation of fragmentation” that depicts the existing approach to health data access across Europe 2 through the establishment of a centralised data system. European Health Data Space: Regulation 2022/0140.

Regulation 98

Regulation Research Development Genome 98

XTalks

MARCH 7, 2024

In a pivotal move for the food industry, the US Food and Drug Administration (FDA) has unveiled industry guidance for genome edited foods derived from plants. Genome editing stands as a cutting-edge technique that ingeniously introduces new traits into plants.

Gene Editing 52

Gene Editing Gene Genomics Genome 52

WCG Clinical

AUGUST 27, 2024

1 This is an important requirement, as the NIH Guidelines were originally created partly in response to public concerns surrounding recombinant DNA and genetic engineering. Many of those original concerns of the 1970s and 1980s surrounding genetic engineering have lessened over time.

Genetic Engineering 52

Genetic Engineering Engineer Compliance Genetics 52

The Pharma Data

JANUARY 19, 2021

But altering the tracr-L with genetic engineering to make it function more like a guide RNA increased CRISPR-Cas9 cuts. The authors suggest natural tracr-L regulates autoimmunity. In bacteria with unaltered tracr-L, levels of CRISPR-related genes were low. And removing tracr-L altogether greatly increased CRISPR-Cas9 expression.

Bacteria 52

Bacteria Gene Editing Research RNA 52

XTalks

JANUARY 21, 2025

The tricuspid valve, one of the heart’s four valves, regulates blood flow from the right atrium to the right ventricle, preventing backflow between these chambers. There, plasma is separated, and tumor DNA is identified by detecting genetic mutations, methylation patterns and fragmentation signals.

FDA Approval 105

FDA Approval Manufacturing Development RNA 105

pharmaphorum

MARCH 10, 2021

bluebird bio is to ask regulators to restart clinical studies of its LentiGlobin for sickle cell disease, after an investigation concluded that a case of acute myeloid leukaemia (AML) was “very unlikely” to be caused by the gene therapy. bluebird bio’s Philip Gregory. Shares in bluebird ticked up following the announcement.

Gene Therapy 59

Gene Therapy Gene Trials Gene Expression 59

Scienmag

JANUARY 11, 2021

These biomarkers are epigenetic, meaning they involve changes to molecular factors that regulate genome activity such as gene expression independent of DNA sequence, and can be passed down to future generations. In a […].

Gene Expression 41

Gene Expression DNA Genomics Genome 41

The Pharma Data

JULY 11, 2021

Since then, there has been an increasing body of findings that the microbiome, which is sometimes also referred to as the second human genome, is not only of central importance for digestion, but also influences, if not controls, at least a large number of body functions. The immune system is mentioned particularly frequently.

Bacteria 52

Bacteria Genetics Scientist Regulation 52

The Pharma Data

SEPTEMBER 7, 2020

US regulators have approved Genentech’s Gavreto (pralsetinib) for the treatment of adults with metastatic rearranged during transfection (RET) fusion-positive non-small cell lung cancer (NSCLC). The personalised cancer treatment has received conditional approval in the US. Source link.

FDA Approval 52

FDA Approval Genomics Genome Genetics 52

XTalks

APRIL 5, 2021

The Human Genome Project could not have succeeded without the use of bioinformatics. Specific skills are required to succeed in this job; these include advanced writing skills for scientific literature, developing software tools, working on genome sequencing projects, and designing DNA sequencing libraries. Bioinformatics Engineer.

Bioinformatics 59

Bioinformatics Engineer Scientist Genome 59

The Pharma Data

MARCH 23, 2022

Polymerase is a viral protein that directs how Ebola virus replicates its genome as it infects new hosts. Back in 2018, researchers tested a broad-spectrum antiviral candidate called remdesivir/VEKLURY, which acts as a nucleotide decoy to get incorporated into the viral RNA genome and stop viral polymerase.

Protein 52

Protein Genomics Genome Research 52

Advarra

SEPTEMBER 29, 2022

Informed consent is one of the central protections the regulations provide to research subjects. The regulatory requirements for informed consent will vary depending upon which regulations apply to the conduct of a particular study. The regulations are very specific regarding what to include in the ICF and what to exclude.

Regulation 52

Regulation Research Genetics Compliance 52

XTalks

MARCH 18, 2024

By genetically editing microorganisms, scientists can now manipulate the metabolic pathways to produce foods with desirable properties. The precision fermentation study highlights how genetically engineered microorganisms can inhibit the growth of foodborne pathogens.

Genetic Engineering 52

Genetic Engineering Genetics Production Protein 52

Roots Analysis

MARCH 24, 2022

Scientific fields involved in high throughput measurement of biological molecules are referred with the suffix- omics including, transcriptomics, genomics, proteomics and metabolomics. Genomics is the study of genetic material within a cell, and transcriptomics is the study of gene activity in different cells.

Clinical Research 52

Clinical Research Development Research Drug Delivery Systems 52

XTalks

OCTOBER 4, 2024

Whole-Genome Sequencing Reveals Genetic Causes of Cerebral Palsy Canadian researchers have unveiled significant genetic factors that may contribute to the development of cerebral palsy. Advocate for Change: Reach out to policymakers and advocate for laws and regulations that support the rights of individuals with cerebral palsy.

Genetics 52

Genetics Botox Research Development 52

Pharma Marketing Network

OCTOBER 17, 2024

Personalized Medicine and Targeted Campaigns Personalized medicine is revolutionizing the pharmaceutical industry by tailoring treatments to individual genetic profiles and health conditions. Companies must navigate complex regulations such as GDPR and HIPAA to ensure that their data collection and usage practices are compliant.

Marketing 52

Marketing Pharma Companies Regulation Production 52

Trialfacts

SEPTEMBER 12, 2024

Their work is driven by a profound understanding of disease biology and supported by advanced discovery platforms such as genetics and genomics, gene editing, bioinformatics, proteomics, bioengineering, image analysis, biobanks, disease-specific stem cell lines, and various animal models.

Research 52

Research Gene Editing Biobanking Bioinformatics 52

Advarra

NOVEMBER 29, 2022

However, despite the promise of these therapies, the regulations governing them lag the science, which in turn hinders the clinical translation of these novel medicines. While each ultra-rare genetic disorder may have a very small patient population, when these conditions are grouped together, they make up a significant number.

Gene Therapy 52

Gene Therapy Gene Production Clinical Trials 52

Pharmaceutical Technology

FEBRUARY 3, 2023

The field of genomic medicine has reached a true turning point. With scientists fervently developing mRNA vaccines, nucleic acid therapeutics, and viral vector-based gene therapies, clinicians are set to have a growing number of tools available to treat a wide range of conditions, from infectious diseases to genetic disorders and more.

Genome 244

Genome Genomics Medicine Gene Therapy 244

XTalks

FEBRUARY 27, 2024

There have been significant advancements in new rare disease drugs, particularly for genetic disorders that can be treated by correcting, replacing or silencing defective genes. These regulations offer benefits such as tax credits, grant funding and extended market exclusivity for approved drugs.

Research 59

Research Drugs Gene Therapy Clinical Trials 59

XTalks

SEPTEMBER 30, 2020

The research shows that the activity of the immune messenger type 1 interferon (IFN) protein is diminished, either by genetic mutations or an autoimmune attack by neutralizing antibodies against it, in a subset of COVID-19 patients. Casanova’s lab is now searching for the genetic driver behind the autoantibodies. percent of men.

Antibody 135

Antibody Genetics Research In-Vitro 135

Roots Analysis

OCTOBER 30, 2023

These RNA based therapeutics play a crucial role in protein production and regulation of gene functions. Self-amplifying RNA (saRNA): Self amplifying RNA is an engineered form of RNA, combining the amplifying genome (native to certain viruses) to the therapeutic gene of interest.

RNA 40

RNA Vaccination Vaccine Development 40

pharmaphorum

JANUARY 29, 2021

Genome editing is an exciting but still nascent field, and companies in the area face as many obstacles as they do opportunities. ZFPs can be engineered to make zinc finger nucleases, or ZFNs, which are proteins that can be used to edit genomes by knocking select genes in or out to specifically modify DNA sequences.

Gene Editing 145

Gene Editing Gene Gene Therapy In-Vivo 145