Pharmaceutical Technology

FEBRUARY 9, 2023

Ibutamoren mesylate overview Ibutamoren mesylate (MK-677) is under development for the treatment of pediatric growth hormone deficiency (PGHD), Turner syndrome, children born small for gestational age (SGA), idiopathic short stature, nonalcoholic fatty liver disease (NAFLD) and Prader Willi syndrome. It is administered orally.

Hormones 100

Hormones Clinical Trials Clinical Trials Drugs 100

Medical Xpress

DECEMBER 12, 2022

Ana Guadaño at the Alberto Sols Biomedical Research Institute (IIBM, a combined CSIC-UAM center) and involving the Complutense University of Madrid (UCM), used CRISPR gene editing techniques to incorporate into mice a mutation of the MCT8 protein responsible for transporting thyroid hormones to the interior of the cell.

Gene Editing 75

Gene Editing Genetics Hormones Medicine 75

Medical Xpress

DECEMBER 6, 2022

Non-Hispanic Black women with hormone receptor (HR)-positive/HER2-negative, lymph node-positive breast cancer had worse outcomes compared to non-Hispanic whites, Asians, and Hispanics, despite similar 21-gene recurrence scores, according to a study presented at the 2022 San Antonio Breast Cancer Symposium, held December 6-10, 2022.

HR 75

HR Hormones Genetics Gene 75

XTalks

MARCH 7, 2024

Optimizing Sleep During Perimenopause and Beyond Sleep plays a crucial role in overall health, particularly for midlife women transitioning into menopause, a phase marked by perimenopause where hormonal changes can severely disrupt sleep due to symptoms like nocturnal hot flashes.

Genetics 115

Genetics Hormones Genomics Genome 115

pharmaphorum

SEPTEMBER 14, 2020

Merck & Co has signed a multi-billion cancer drug development deal, which will see it investing $1 billion in partner Seattle Genetics. Seattle Genetics will receive a $600 million upfront payment and Merck will make a $1.0 million shares of Seattle Genetics common stock at a price of $200 per share.

Genetics 52

Genetics Development Drugs Protein 52

The Pharma Data

SEPTEMBER 15, 2020

MSD has signed two new oncology-based deals with Seattle Genetics which together could be worth up to around $4.4 For this, MSD will put up $600 million up front and a $1 billion equity investment for five million of Seattle Genetics’ shares, while the latter will also have the option to scoop up an additional $2.6 Matt Fellows.

Genetics 52

Genetics Development Hormones Licensing 52

Pharmaceutical Technology

JANUARY 22, 2023

The mutation leads to disordered thyroid hormone transport, which causes patients to experience intellectual and motor disabilities. Egetis is banking on tiratricol, an oral small molecule that restores dysfunctional thyroid hormone signalling, to be the first drug approved for this condition.

Drugs 317

Drugs Gene Hormones Clinical Trials 317

XTalks

APRIL 15, 2025

The approval marks the first FDA-approved therapy specifically targeting hyperphagia in this rare genetic disorder. Since the FDA approved recombinant human growth hormone (rhGH) for PWS in 2000, multiple companies have tried and failed to develop a targeted treatment for hyperphagia.

FDA Approval 59

FDA Approval Clinical Trials Clinical Trials Trials 59

BioSpace

AUGUST 31, 2021

This is an effort to eliminate severe adverse reactions by matching the birth control to the genetics and hormones of the individual.

Hormones 61

Hormones Medicine Genetics 61

Worldwide Clinical Trials

JULY 8, 2024

Genetic Factors : Certain genetic mutations, such as those in DNA repair genes, can affect how cells respond to radiation. Hormonal Status : A body’s hormones, such as levels of reproductive hormones and thyroid function, can impact tissue responses to radiation therapy.

Hormones 130

Hormones Regulation Clinical Trials Clinical Trials 130

XTalks

MAY 17, 2023

While the exact physiology of vasomotor symptoms is not fully understood, it is believed that the significant fluctuations in reproductive hormones play a role in triggering these symptoms. Hormone replacement therapy is thought to be one of the most effective treatments for vasomotor symptoms.

Hormones 95

Hormones FDA Approval Drugs Clinical Trials 95

Scienmag

NOVEMBER 4, 2020

Researchers from Nara Institute of Science and Technology find that the plant hormone ethylene mediates the invasion of hosts by parasitic plants Credit: Satoko Yoshida Nara, Japan – Mutants that reveal the secrets of how plants attack?

Hormones 82

Hormones Research Bioinformatics Genetics 82

Scienmag

SEPTEMBER 13, 2021

Philadelphia, September 13, 2021—Researchers at Children’s Hospital of Philadelphia (CHOP) have demonstrated that an experimental device can improve blood sugar control in patients who developed diabetes after their pancreas was removed to treat their hyperinsulinism, a genetic disease in which the pancreas produces too much insulin.

Genetic Disease 52

Genetic Disease Insulin Hormones Research 52

Medical Xpress

FEBRUARY 14, 2025

This condition is more prevalent in Asian countries and has been associated with various genetic and hormonal factors. Ossification of the posterior longitudinal ligament (OPLL) is a progressive spinal disease characterized by ectopic bone formation in the spine, leading to severe neurological symptoms due to spinal cord compression.

Hormones 45

Hormones Genetics 45

Scienmag

AUGUST 14, 2020

Findings have implications for seed production and crop yield and could help rewrite textbooks, translating to practical applications for plant reproduction Credit: Dr. Wangshu Mou Researchers at the University of Maryland (UMD) have discovered an entirely new role for a well-known plant molecule called ACC, providing the first clear example of ACC (..)

Hormones 59

Hormones Production Research Genetics 59

Scienmag

MARCH 11, 2021

During pregnancy, the hormone progesterone helps to […]. The study in mice — published online in the Proceedings of the National Academy of Sciences — provides novel insights for developing treatments.

Hormones 74

Hormones Development Research Gene 74

Scienmag

MARCH 26, 2021

Bottom Line: Various genetic alterations in circulating tumor cells (CTCs) were associated with clinical outcomes and resistance to hormone therapy in patients with metastatic castrate-resistant prostate cancer (mCRPC).

Hormones 40

Hormones Genetics Research Medicine 40

Scienmag

DECEMBER 7, 2020

University of Pennsylvania biologists have uncovered one way plants respond to hormonal cues. A similar process is likely at play in mammals. Just like other organisms, plants must respond dynamically to a variety of cues over their lifetime.

Hormones 63

Hormones Gene Genetics Medicine 63

pharmaphorum

JANUARY 16, 2023

Hormone replacement therapy (HRT) could cut the risk of Alzheimer’s in some women at elevated risk of the disease, according to researchers in the UK.

Hormones 75

Hormones Genotype Research Genetics 75

XTalks

SEPTEMBER 15, 2020

A vaccine developed by Swedish company Diamyd Medical has demonstrated significant treatment efficacy in a predefined genetic subgroup of individuals with type 1 diabetes in a Phase IIb clinical trial. Hannelius said this highlights the importance of genetics when developing therapies for type 1 diabetes. “It

Vaccine 103

Vaccine Vaccination Insulin Trials 103

Scienmag

MAY 18, 2021

Mutations associated with autism can inhibit the release of the bonding hormone oxytocin and cause abnormal social behavior in mice Credit: Tokyo University of Science Autism spectrum disorder is a neurodevelopmental condition involving impaired social abilities, and this makes it a fascinating subject for neuroscientists like Prof.

Hormones 56

Hormones Genetics Medicine 56

Drug Discovery Today

FEBRUARY 13, 2020

Experts in the emotional needs of small children say increased levels of the stress hormone cortisol in babies and small children who are separated from their parents, especially their mothers, could have a long-term genetic impact on future generations.

Gene 40

Gene Hormones Genetics Medicine 40

XTalks

SEPTEMBER 17, 2020

Symptoms and Etiology: Caused by an overproduction of growth hormone, acromegaly primarily affects adults. By reducing the amount of growth hormone in the blood, progressive enlargement of bones should be slowed. By reducing the amount of growth hormone in the blood, progressive enlargement of bones should be slowed.

Trials 98

Trials Gene Hormones Clinical Trials 98

Delveinsight

SEPTEMBER 27, 2021

Furthermore, the condition carries the risk of differential diagnosis as more than 50 genetic/metabolic diseases are associated with infantile spasms, and many patients have other disorders that cause developmental delays (e.g., Early diagnosis is necessary for better treatment outcomes. cerebral palsy, Down syndrome, tuberous sclerosis, etc.)

Marketing 77

Marketing Hormones Radiology Pharma Companies 77

pharmaphorum

SEPTEMBER 24, 2021

AstraZeneca and Merck & Co PARP inhibitor Lynparza is already used to treat prostate cancer associated with a specific genetic mutation, but could see the drug’s use broadened after a positive phase 3 trial.

Hormones 52

Hormones Genetics Drugs Sales 52

XTalks

AUGUST 22, 2024

Hypoparathyroidism arises when the parathyroid glands fail to produce enough parathyroid hormone (PTH) or when the PTH produced is ineffective. In some cases, the cause could be autoimmune or genetic. Hypoparathyroidism is most commonly caused due to accidental injury to or the removal of the parathyroid glands.

Hormones 52

Hormones FDA Approval Trials Clinical Trials 52

pharmaphorum

JULY 28, 2022

. “We are currently testing this hypothesis, with the goal of pursuing a development candidate targeting INHBE in the near future,” said Paul Nioi, head of Alnylam’s human genetics group.

Biobanking 52

Biobanking Gene Gene Silencing Drugs 52

XTalks

MARCH 7, 2024

The team talks about the differences between genetically modified organisms (GMO) and gene edited foods, as well as whether these foods could be considered organic. These foods are banned in other countries for a variety of reasons, such as the inclusion potentially unsafe dyes, hormones and preservatives.

Gene Editing 52

Gene Editing Gene Genomics Genome 52

The Pharma Data

OCTOBER 22, 2020

That means a woman already predisposed to have a dissection is more likely to have one during pregnancy, possibly due to hormones and changes to the body during pregnancy and postpartum. The researchers found that 19% of aortic dissections in women younger than 35 were associated with pregnancy.

Cardiology 52

Cardiology Hormones Genetics Research 52

Trialfacts

MAY 23, 2023

They also want to study the contribution of stress, negative thinking patterns, and genetic and hormonal factors. In particular, they want to explore how brain activity influences binge eating episodes.

Research 52

Research Hormones Genetics Development 52

XTalks

MARCH 28, 2024

Causes and Risk Factors for Endometriosis As the exact cause of endometriosis remains unclear, many potential causes are being proposed, including retrograde menstruation (where menstrual blood flows back into the pelvic cavity instead of leaving the body), immune system disorders and hormonal imbalances.

Hormones 40

Hormones Life Science In-Vitro Drugs 40

The Pharma Data

DECEMBER 17, 2020

This patient had a genetic mutation that ruxolitinib is known to work on. Forbes said it’s not clear if other people with type 1 diabetes also have this specific genetic mutation. Insulin is a hormone that ushers the sugars from foods into the body’s cells to be used as fuel.

Insulin 52

Insulin Genetics Doctor Doctors 52

Delveinsight

JULY 30, 2020

The buildup in adrenal glands leads to the insufficient hormonal response, thus leading to several of the symptoms such as deficiency of steroid hormones (mainly cortisol and aldosterone), impaired cortisol secretion, and others that are harbingers of the disease. The disorder can occur at any stage of life and vary with severity.

Hormones 52

Hormones Marketing Gene Trials 52

The Pharma Data

JUNE 2, 2023

“These additional data on Verzenio and Jaypirca build on the evidence supporting the role each of these medicines play in improving the treatment paradigms for patients with node-positive, high risk early breast cancer and covalent BTK inhibitor pre-treated relapsed or refractory MCL, respectively,” said David Hyman, M.D.,

HR 52

HR Hormones Medicine Trials 52

The Pharma Data

AUGUST 15, 2021

Advise patients of these risks and the need for effective non-hormonal contraception. WELIREG can render some hormonal contraceptives ineffective. This is a rare genetic disease with an estimated incidence of 10,000 people in the U.S. WELIREG can render some hormonal contraceptives ineffective.

Hormones 52

Hormones Clinical Trials Clinical Trials Trials 52

XTalks

MARCH 13, 2024

Hormone-based therapeutics aim to delay glaucoma progression by enhancing estrogen’s potential protective effects. There are also studies examining gene therapy-based techniques to repair or replace genetic defects contributing to this disease.

Gene Therapy 111

Gene Therapy Gene Life Science DNA 111

Olympian Clinical Research

NOVEMBER 6, 2023

While the exact cause is unknown, factors like genetics, inflammation, and hormones play a role. Here are some common triggers of HS: Hormonal Changes: Many individuals with HS report flare-ups during periods of hormonal change, such as menstruation, pregnancy, or menopause.

Hormones 52

Hormones Doctor Doctors Clinical Trials 52