Medical Xpress

DECEMBER 6, 2022

Non-Hispanic Black women with hormone receptor (HR)-positive/HER2-negative, lymph node-positive breast cancer had worse outcomes compared to non-Hispanic whites, Asians, and Hispanics, despite similar 21-gene recurrence scores, according to a study presented at the 2022 San Antonio Breast Cancer Symposium, held December 6-10, 2022.

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HR Hormones Genetics Gene 71

The Pharma Data

SEPTEMBER 15, 2020

MSD has signed two new oncology-based deals with Seattle Genetics which together could be worth up to around $4.4 For this, MSD will put up $600 million up front and a $1 billion equity investment for five million of Seattle Genetics’ shares, while the latter will also have the option to scoop up an additional $2.6 Matt Fellows.

Genetics 52

Genetics Development Hormones Licensing 52

XTalks

MARCH 7, 2024

Optimizing Sleep During Perimenopause and Beyond Sleep plays a crucial role in overall health, particularly for midlife women transitioning into menopause, a phase marked by perimenopause where hormonal changes can severely disrupt sleep due to symptoms like nocturnal hot flashes.

Genetics 101

Genetics Hormones Genome Genomics 101

BioSpace

AUGUST 31, 2021

This is an effort to eliminate severe adverse reactions by matching the birth control to the genetics and hormones of the individual.

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Hormones Medicine Genetics 62

WCG Clinical

OCTOBER 8, 2024

Latin America’s genetic diversity and unique health challenges are driving groundbreaking clinical research, offering new insights into disease prevention, innovative medicine, and treatments. The barbasco root is a plant used in Mexican traditional medicine that has been used to develop synthetic hormones. [1]

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XTalks

JUNE 20, 2022

TTR is made in the liver and is involved in carrying the thyroid hormone thyroxine (T4) and retinol (vitamin A) to the liver. Defects in the TTR transporter leads to a buildup of amyloid protein (amyloidosis) in tissues and organs, occurring mainly in the nerves in the peripheral nervous system.

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FDA Approval Protein Genetics RNA 95

Worldwide Clinical Trials

JULY 8, 2024

Genetic Factors : Certain genetic mutations, such as those in DNA repair genes, can affect how cells respond to radiation. Hormonal Status : A body’s hormones, such as levels of reproductive hormones and thyroid function, can impact tissue responses to radiation therapy.

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Hormones Regulation Clinical Trials Clinical Trials 130

Scienmag

SEPTEMBER 13, 2021

Philadelphia, September 13, 2021—Researchers at Children’s Hospital of Philadelphia (CHOP) have demonstrated that an experimental device can improve blood sugar control in patients who developed diabetes after their pancreas was removed to treat their hyperinsulinism, a genetic disease in which the pancreas produces too much insulin.

Genetic Disease 52

Genetic Disease Insulin Hormones Research 52

Scienmag

MARCH 26, 2021

Bottom Line: Various genetic alterations in circulating tumor cells (CTCs) were associated with clinical outcomes and resistance to hormone therapy in patients with metastatic castrate-resistant prostate cancer (mCRPC).

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Hormones Genetics Research Medicine 40

Pharma Packaging Solutions

JUNE 30, 2023

Hormones (such as insulin, glucagon, and growth hormone, to name a few) are produced by recombinant DNA, as are blood factors, thrombolytic agents, interferons, monoclonal antibodies, therapeutic enzymes, and more.

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Recombinant DNA Technology Packaging Packaging Gene Therapy 52

Trialfacts

MAY 27, 2024

This study combines brain imaging, genetics, and surveys to uncover crucial insights. Be part of cutting-edge research exploring how personality traits affect mental health. Are you a man aged 18 – 45? Participate in an online questionnaire and a single 7- to 8-hour visit including cognitive testing, an interview, and an MRI scan.

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Gene Hormones Research Doctors 52

Scienmag

AUGUST 14, 2020

Findings have implications for seed production and crop yield and could help rewrite textbooks, translating to practical applications for plant reproduction Credit: Dr. Wangshu Mou Researchers at the University of Maryland (UMD) have discovered an entirely new role for a well-known plant molecule called ACC, providing the first clear example of ACC (..)

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Hormones Production Research Genetics 59

XTalks

AUGUST 22, 2024

Hypoparathyroidism arises when the parathyroid glands fail to produce enough parathyroid hormone (PTH) or when the PTH produced is ineffective. In some cases, the cause could be autoimmune or genetic. Hypoparathyroidism is most commonly caused due to accidental injury to or the removal of the parathyroid glands.

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Hormones FDA Approval Trials Clinical Trials 52

Trialfacts

MAY 27, 2024

This study will use brain imaging, genetics, questionnaires, and other assessments to map the brain systems and genes that underlie risk and resilience for mental health problems. Findings from this study may assist in the development of improved diagnosis, early intervention, and treatment.

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Gene Hormones Research Doctors 52

XTalks

MARCH 28, 2024

Causes and Risk Factors for Endometriosis As the exact cause of endometriosis remains unclear, many potential causes are being proposed, including retrograde menstruation (where menstrual blood flows back into the pelvic cavity instead of leaving the body), immune system disorders and hormonal imbalances.

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Hormones Life Science In-Vitro Drugs 40

pharmaphorum

AUGUST 16, 2022

AstraZeneca and Merck & Co’s PARP inhibitor Lynparza is already used to treat prostate cancer associated with a specific genetic mutation, but could see its use broadened if a new marketing application is approved by the FDA. months and 16.6 months, respectively.

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Drug Discovery Today

FEBRUARY 13, 2020

Experts in the emotional needs of small children say increased levels of the stress hormone cortisol in babies and small children who are separated from their parents, especially their mothers, could have a long-term genetic impact on future generations.

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Gene Hormones Genetics Medicine 40

Scienmag

NOVEMBER 4, 2020

Researchers from Nara Institute of Science and Technology find that the plant hormone ethylene mediates the invasion of hosts by parasitic plants Credit: Satoko Yoshida Nara, Japan – Mutants that reveal the secrets of how plants attack?

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Hormones Research Bioinformatics Genetics 82

XTalks

MARCH 7, 2024

The team talks about the differences between genetically modified organisms (GMO) and gene edited foods, as well as whether these foods could be considered organic. These foods are banned in other countries for a variety of reasons, such as the inclusion potentially unsafe dyes, hormones and preservatives.

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Gene Editing Gene Genome Genomics 52

Scienmag

MARCH 11, 2021

During pregnancy, the hormone progesterone helps to […]. The study in mice — published online in the Proceedings of the National Academy of Sciences — provides novel insights for developing treatments.

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pharmaphorum

JANUARY 16, 2023

Hormone replacement therapy (HRT) could cut the risk of Alzheimer’s in some women at elevated risk of the disease, according to researchers in the UK.

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Hormones Genotype Research Genetics 75

Scienmag

MAY 18, 2021

Mutations associated with autism can inhibit the release of the bonding hormone oxytocin and cause abnormal social behavior in mice Credit: Tokyo University of Science Autism spectrum disorder is a neurodevelopmental condition involving impaired social abilities, and this makes it a fascinating subject for neuroscientists like Prof.

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Hormones Genetics Medicine 56

Scienmag

DECEMBER 7, 2020

University of Pennsylvania biologists have uncovered one way plants respond to hormonal cues. A similar process is likely at play in mammals. Just like other organisms, plants must respond dynamically to a variety of cues over their lifetime.

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Hormones Gene Genetics Medicine 63

Trialfacts

MAY 23, 2023

They also want to study the contribution of stress, negative thinking patterns, and genetic and hormonal factors. In particular, they want to explore how brain activity influences binge eating episodes.

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pharmaphorum

JULY 28, 2022

. “We are currently testing this hypothesis, with the goal of pursuing a development candidate targeting INHBE in the near future,” said Paul Nioi, head of Alnylam’s human genetics group.

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Biobanking Gene Gene Silencing Drugs 52

Roots Analysis

OCTOBER 24, 2023

This has led to their widespread production and extensive use in the treatment of various indications including hormonal imbalances, oncological disorders and respiratory disorders. Hormones: Biologic HPAPIs which are not classified as oncology drugs include hormones, narcotics and retinoids.

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The Pharma Data

JUNE 2, 2023

“These additional data on Verzenio and Jaypirca build on the evidence supporting the role each of these medicines play in improving the treatment paradigms for patients with node-positive, high risk early breast cancer and covalent BTK inhibitor pre-treated relapsed or refractory MCL, respectively,” said David Hyman, M.D.,

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HR Hormones Medicine Trials 52

Olympian Clinical Research

NOVEMBER 6, 2023

While the exact cause is unknown, factors like genetics, inflammation, and hormones play a role. Here are some common triggers of HS: Hormonal Changes: Many individuals with HS report flare-ups during periods of hormonal change, such as menstruation, pregnancy, or menopause.

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Hormones Doctors Doctor Clinical Trials 52

Delveinsight

AUGUST 31, 2021

FDA’s Green Flag to Ascendis’s Once-Weekly SKYTROFA for Treatment of Pediatric Growth Hormone Deficiency. Growth Hormone Deficiency , commonly known as dwarfism, can constitute short stature and complications with metabolism, which arise due to inadequate production of growth hormones by the pituitary gland inside the body.

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Hormones FDA Approval Development Drugs 60

The Pharma Data

OCTOBER 22, 2020

That means a woman already predisposed to have a dissection is more likely to have one during pregnancy, possibly due to hormones and changes to the body during pregnancy and postpartum. The researchers found that 19% of aortic dissections in women younger than 35 were associated with pregnancy.

Cardiology 52

Cardiology Hormones Genetics Research 52

Roots Analysis

AUGUST 31, 2023

An additional level of genetic control is provided by gene switches that are located upstream of the promoter region. These genetic switches assist transcription factors in binding to the promoter region. This is true for any genetic products or byproducts of the metabolic pathways that are toxic to the host.

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Gene Gene Therapy Gene Expression Regulation 40

Roots Analysis

SEPTEMBER 9, 2024

Algal Expression System: This expression system is used in genetic engineering, biofuel production, botany. Hormones (includes recombinant insulin, erythropoietin and growth hormones) Enzyme replacement therapies used in treatment of rare genetic disorders such as Gaucher disease.

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Protein Gene Production DNA 40

Trialfacts

JANUARY 16, 2024

In particular, they want to explore the impact of stress, negative thinking patterns, and genetic and hormonal factors on eating behaviours. With the knowledge gained from this study, researchers hope to better understand the connection between mind and body. Why Participate?

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Research Hormones Genetics 52

Delveinsight

SEPTEMBER 27, 2021

Furthermore, the condition carries the risk of differential diagnosis as more than 50 genetic/metabolic diseases are associated with infantile spasms, and many patients have other disorders that cause developmental delays (e.g., Early diagnosis is necessary for better treatment outcomes. cerebral palsy, Down syndrome, tuberous sclerosis, etc.)

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XTalks

FEBRUARY 14, 2024

Moreover, these advancements have enabled healthcare providers to tailor treatments according to the genetic profile of each tumor, which has, in turn, helped enhance efficacy while minimizing adverse effects. In fact, for healthcare providers and medical device companies, these advancements are both a challenge and an opportunity.

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Hormones Development Genetics Life Science 52

The Pharma Data

DECEMBER 17, 2020

This patient had a genetic mutation that ruxolitinib is known to work on. Forbes said it’s not clear if other people with type 1 diabetes also have this specific genetic mutation. Insulin is a hormone that ushers the sugars from foods into the body’s cells to be used as fuel.

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Insulin Genetics Doctors Doctor 52

Olympian Clinical Research

DECEMBER 19, 2023

Family History: Genetics plays a significant role. Hormonal Changes: Hormonal fluctuations, especially during puberty, can influence the severity and onset of psoriasis. Hormonal Changes: Hormonal fluctuations, especially during puberty, can influence the severity and onset of psoriasis.

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Clinical Research Hormones Clinical Trials Clinical Trials 52