Scienmag

DECEMBER 7, 2020

University of Pennsylvania biologists have uncovered one way plants respond to hormonal cues. A similar process is likely at play in mammals. Just like other organisms, plants must respond dynamically to a variety of cues over their lifetime.

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Scienmag

MARCH 26, 2021

Bottom Line: Various genetic alterations in circulating tumor cells (CTCs) were associated with clinical outcomes and resistance to hormone therapy in patients with metastatic castrate-resistant prostate cancer (mCRPC).

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The Pharma Data

JUNE 2, 2023

“These additional data on Verzenio and Jaypirca build on the evidence supporting the role each of these medicines play in improving the treatment paradigms for patients with node-positive, high risk early breast cancer and covalent BTK inhibitor pre-treated relapsed or refractory MCL, respectively,” said David Hyman, M.D.,

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Scienmag

MAY 18, 2021

Mutations associated with autism can inhibit the release of the bonding hormone oxytocin and cause abnormal social behavior in mice Credit: Tokyo University of Science Autism spectrum disorder is a neurodevelopmental condition involving impaired social abilities, and this makes it a fascinating subject for neuroscientists like Prof.

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The Pharma Data

OCTOBER 22, 2020

That means a woman already predisposed to have a dissection is more likely to have one during pregnancy, possibly due to hormones and changes to the body during pregnancy and postpartum. The researchers found that 19% of aortic dissections in women younger than 35 were associated with pregnancy.

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The Pharma Data

DECEMBER 17, 2020

8 issue of the New England Journal of Medicine — stopped short of calling the drug a cure for type 1 diabetes. But Forbes, an assistant professor of pediatrics, immunology, allergy and rheumatology at Baylor College of Medicine in Houston, said the patient’s diabetes appears to have been reversed.

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The Pharma Data

SEPTEMBER 3, 2020

Our new study offers an important basis from which to start developing new treatment strategies for a rare form of cancer, which starts in the hormone-producing cells of the pancreas,” noted Dr Anguraj Sadanandam, team leader in Systems and Precision Cancer Medicine at The ICR, London. “We

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Delveinsight

JULY 30, 2020

The buildup in adrenal glands leads to the insufficient hormonal response, thus leading to several of the symptoms such as deficiency of steroid hormones (mainly cortisol and aldosterone), impaired cortisol secretion, and others that are harbingers of the disease. The disorder can occur at any stage of life and vary with severity.

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The Pharma Data

JANUARY 7, 2021

However, Sanofi’s programs have significant depth below the waterline that could result in the approval of important medicines to treat difficult diseases. Another area where Sanofi is investing is through the Expanded Genetic Alphabet platform it gained at the end of 2019 through the $2.5 billion acquisition of Synthorx.

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The Pharma Data

NOVEMBER 24, 2020

25, 2020 /CNW/ – On August 21, 2020 , Health Canada approved Lynparza® (olaparib), for the treatment of adult patients with deleterious or suspected deleterious germline and/or somatic BRCA or ATM- mutated metastatic castration-resistant prostate cancer (mCRPC) who have progressed following prior treatment with a new hormonal agent (NHA).

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XTalks

AUGUST 15, 2023

Akeega is a dual-action tablet (DAT) that contains the company’s androgen receptor-targeting hormone therapy Zytiga (abiraterone acetate) and PARP inhibitor (poly [ADP-ribose] polymerase inhibitor) niraparib. Niraparib is also sold by GSK under the name Zejula in other indications.

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Roots Analysis

OCTOBER 24, 2023

Owing to the advancement in clinical pharmacology and oncology domain, and the rising demand for targeted therapeutics and precision medicines, high potency active pharmaceutical ingredients (HPAPIs) and cytotoxic drugs have become one of the key areas of interest to researchers and drug manufacturers across the globe.

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pharmaphorum

DECEMBER 23, 2020

But there was some considerable progress in other fields of medicine even though research efforts were diverted away, reports Richard Staines. NT-814 is a non-hormonal drug that works on the neurokinin (NK) 1,3 receptor antagonist, thus treating the vasomotor symptoms associated with the menopause.

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The Pharma Data

JUNE 24, 2021

The prognosis for men with advanced prostate cancer has significantly improved since the introduction of novel hormone therapies, but additional therapeutic options are needed for the approximately 25 percent of men with tumors harboring DNA damage response (DDR) gene mutations, who may have poorer outcomes,” said Chris Boshoff, M.D.,

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The Pharma Data

JANUARY 11, 2021

What’s more, this protective effect holds even if the person carries excess weight, researchers reported recently in the journal Nature Medicine. Bronfman Institute of Personalized Medicine with the Icahn School of Medicine at Mount Sinai, in New York City. It’s not yet clear why this link might exist, Cypess said.

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XTalks

DECEMBER 22, 2021

RNA therapeutics hold promise as powerful treatments for diseases, including those that are genetic-based. They can provide continuous real-time monitoring of metabolites, bacteria, hormones, glucose and other elements in these fluids. RNA Therapeutics. The deal is worth $1.5 Prior to this, Lilly struck an agreement worth $1.25

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The Pharma Data

MAY 13, 2021

Millions of Women Over 30 Suffer From This Hidden Hormonal Disorder That Keeps You Overweight, Weakens Your Heart, & Starves Your Brain. And it led to a SHOCKING revelation that saved my life, you see… This Hidden Hormonal Defect Makes Weight Loss Impossible And Is the REAL Reason You’re Frustrated & Struggling.

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The Pharma Data

JUNE 18, 2021

lead study investigator of the Phase 3 RESONATE-2 trial, and Professor of Medicine at the Wilmot Cancer Institute, University of Rochester. IMBRUVICA ® is the only FDA-approved medicine in WM and cGVHD. IMBRUVICA ® was one of the first medicines to receive FDA approval via the Breakthrough Therapy Designation pathway.

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The Pharma Data

MAY 16, 2021

Of course, but you need the RIGHT ONE for your Specific Genetics. Now you can have the prefect outline to map out your diet to the letter, follow appropriate training suited for your genetic needs, and know exactly how to tailor cardio so you don’t eat up that precious muscle mass you have. And it doesn’t stop there.

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The Pharma Data

MAY 15, 2021

I always knew that I wasn’t what you would call “genetically gifted” In fact, many people in my family struggle with their weight and self-esteem. Research shows that there is a connection between arm fat and the hormones testosterone and estrogen.

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XTalks

SEPTEMBER 11, 2024

“Failure to study medications and other interventions in a broad sampling has led to women experiencing adverse effects from medications at nearly twice the rate of men ,” says Dr. Jaclyn Jansen, MD, MS, Medical Director of the Medical Department, General Medicine, Medpace. It moves away from a one-size-fits-all approach ( Figure 2 ).

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pharmaphorum

FEBRUARY 26, 2021

UK-based doctor, Dr Natasha Larmie is on a mission to make medicine weight inclusive. We would never use such a useless screening tool in any other area of medicine, so why do we still use BMI?” As a doctor, I think it is my responsibility to practice medicine fairly and without discrimination. Natasha says. “I

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Worldwide Clinical Trials

JULY 8, 2024

In nuclear medicine, radiopharmaceuticals play a pivotal role in two primary applications: Diagnostic Imaging Radiopharmaceuticals are administered to patients, where they accumulate in specific organs or tissues of interest.

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The Pharma Data

MAY 14, 2021

Your body’s hormones are destroyed from almost a year of starvation. But the reason for my muscular arms has nothing to do with genetics (before starting to lift weights, my arms were as skinny as pipe cleaners). Remember, I’m not genetically gifted in any way. One of the problems of anorexia is how it destroys your thyroid.

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XTalks

MAY 17, 2023

. “Today’s approval of fezolinetant is a significant and long-awaited milestone for individuals in the US who experience moderate to severe vasomotor symptoms during the menopausal transition,” said Genevieve Neal-Perry, MD, PhD, Chair of the UNC School of Medicine Department of Obstetrics and Gynecology, in Astellas’ news release.

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Scienmag

SEPTEMBER 15, 2020

Credit: Michigan State University Differences in biological sex can dictate lifelong disease patterns, says a new study by Michigan State University researchers that links connections between specific hormones present before and after birth with immune response and lifelong immunological disease development.

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XTalks

NOVEMBER 20, 2023

AstraZeneca has won its first-in-class approval for its AKT inhibitor Truqap (capivasertib) in combination with Faslodex (fulvestrant) for treating patients with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer.

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The Pharma Data

AUGUST 15, 2021

Advise patients of these risks and the need for effective non-hormonal contraception. WELIREG can render some hormonal contraceptives ineffective. This is a rare genetic disease with an estimated incidence of 10,000 people in the U.S. WELIREG can render some hormonal contraceptives ineffective. Lactation.

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The Pharma Data

JUNE 18, 2021

deputy head of hematology, University of Amsterdam Faculty of Medicine. IMBRUVICA is the only FDA-approved medicine in WM and cGVHD. IMBRUVICA was one of the first medicines to receive FDA approval via the Breakthrough Therapy Designation pathway. Tell your healthcare provider about all the medicines you take, ?including

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The Pharma Data

MAY 15, 2021

Now imagine the entire length of the field as the 300,000 years of human genetic evolution. However your genetic code IS hardwired to go without food for short periods between times of plenty. What if there was a near “magical” fat burning hormone?… It’s a hormone that signals your fat cells to store more fat.

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Delveinsight

DECEMBER 2, 2020

Smoking – Cigarette smoking, coupled with the genetic factor, can increase the risk of developing Rheumatoid Arthritis. Hormones – It is observed that hormones differentially influence the onset of Rheumatoid Arthritis in premenopausal and postmenopausal women. However, the role of hormones is still unclear.

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XTalks

FEBRUARY 14, 2024

The extensive research in developing more effective and less toxic treatments, such as targeted therapies, immunotherapies and precision medicine , has helped to considerably improve the survival rates for many types of childhood cancers.

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Hormones Development Genetics Life Science 52

Scienmag

MAY 6, 2021

The findings presented today at EADV’s 2021 Spring Symposium, suggest that men with genetic characteristics (phenotypes) sensitive to the male sex hormone androgen, are more likely to experience severe COVID-19 disease. Researchers were driven […].

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The Pharma Data

JUNE 18, 2021

IMBRUVICA is the only FDA-approved medicine in WM and cGVHD. IMBRUVICA was one of the first medicines to receive FDA approval via the Breakthrough Therapy Designation pathway. Tell your healthcare provider about all the medicines you take, ?including with certain other medicines may affect how IMBRUVICA ® ?works

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Delveinsight

DECEMBER 29, 2020

Relugolix is a once-daily, oral gonadotropin-release hormone (GnRH) receptor antagonist. X-linked myotubular myopathy (XLMTM) is a rare genetic neuromuscular disorder and leads to muscle weakness, respiratory failure, and early death. mg and norethindrone acetate (0.5 mg) in the US and Canada.

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The Pharma Data

MAY 15, 2021

And it gets even better: this breakthrough research was conducted using men and women that had horrible genetics—so you KNOW it can work for you too. Using a combination of optimizing your hormones and reducing your calories Monday through Thursday, this will be your “Diet Interval”. This has NOTHING to do with extreme dieting.

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The Pharma Data

JANUARY 21, 2021

Researchers at Washington University School of Medicine in St. They are now working to identify what genetic aberrations are causing ALS in about half of the Maltese patients. They believe this is key to understanding how aggressive prostate cancer subtypes and neuroendocrine prostate cancer (NEPC) develop after hormonal therapies.

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