Scienmag

MARCH 11, 2021

During pregnancy, the hormone progesterone helps to […]. The study in mice — published online in the Proceedings of the National Academy of Sciences — provides novel insights for developing treatments.

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Hormones Development Research Gene 74

Drug Discovery Today

FEBRUARY 13, 2020

Experts in the emotional needs of small children say increased levels of the stress hormone cortisol in babies and small children who are separated from their parents, especially their mothers, could have a long-term genetic impact on future generations.

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Scienmag

DECEMBER 7, 2020

University of Pennsylvania biologists have uncovered one way plants respond to hormonal cues. A similar process is likely at play in mammals. Just like other organisms, plants must respond dynamically to a variety of cues over their lifetime.

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Hormones Gene Genetics Medicine 63

Scienmag

MARCH 26, 2021

Bottom Line: Various genetic alterations in circulating tumor cells (CTCs) were associated with clinical outcomes and resistance to hormone therapy in patients with metastatic castrate-resistant prostate cancer (mCRPC).

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Hormones Genetics Research Medicine 40

The Pharma Data

JUNE 2, 2023

“These additional data on Verzenio and Jaypirca build on the evidence supporting the role each of these medicines play in improving the treatment paradigms for patients with node-positive, high risk early breast cancer and covalent BTK inhibitor pre-treated relapsed or refractory MCL, respectively,” said David Hyman, M.D.,

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Scienmag

MAY 18, 2021

Mutations associated with autism can inhibit the release of the bonding hormone oxytocin and cause abnormal social behavior in mice Credit: Tokyo University of Science Autism spectrum disorder is a neurodevelopmental condition involving impaired social abilities, and this makes it a fascinating subject for neuroscientists like Prof.

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Hormones Genetics Medicine 56

The Pharma Data

OCTOBER 22, 2020

That means a woman already predisposed to have a dissection is more likely to have one during pregnancy, possibly due to hormones and changes to the body during pregnancy and postpartum. The researchers found that 19% of aortic dissections in women younger than 35 were associated with pregnancy.

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Cardiology Hormones Genetics Research 52

The Pharma Data

DECEMBER 17, 2020

8 issue of the New England Journal of Medicine — stopped short of calling the drug a cure for type 1 diabetes. But Forbes, an assistant professor of pediatrics, immunology, allergy and rheumatology at Baylor College of Medicine in Houston, said the patient’s diabetes appears to have been reversed.

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Insulin Genetics Doctors Doctor 52

Delveinsight

JULY 30, 2020

The buildup in adrenal glands leads to the insufficient hormonal response, thus leading to several of the symptoms such as deficiency of steroid hormones (mainly cortisol and aldosterone), impaired cortisol secretion, and others that are harbingers of the disease. The disorder can occur at any stage of life and vary with severity.

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Hormones Marketing Gene Trials 52

The Pharma Data

AUGUST 15, 2021

Advise patients of these risks and the need for effective non-hormonal contraception. WELIREG can render some hormonal contraceptives ineffective. This is a rare genetic disease with an estimated incidence of 10,000 people in the U.S. WELIREG can render some hormonal contraceptives ineffective. Lactation.

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The Pharma Data

MARCH 27, 2021

Novo Nordisk today announced that the Committee for Medicinal Products for Human Use (CHMP) under the European Medicines Agency (EMA) has recommended that the use of Saxenda ® is expanded for the treatment of obesity in adolescents aged 12–17 years. About the phase 3 trial (NCT02918279). About Saxenda ®. Saxenda ® (liraglutide 3.0

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Medicine Trials Hormones Clinical Trials 52

The Pharma Data

JANUARY 7, 2021

However, Sanofi’s programs have significant depth below the waterline that could result in the approval of important medicines to treat difficult diseases. Another area where Sanofi is investing is through the Expanded Genetic Alphabet platform it gained at the end of 2019 through the $2.5 billion acquisition of Synthorx.

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Protein Antibody Genetics Gene Therapy 52

Roots Analysis

OCTOBER 24, 2023

Owing to the advancement in clinical pharmacology and oncology domain, and the rising demand for targeted therapeutics and precision medicines, high potency active pharmaceutical ingredients (HPAPIs) and cytotoxic drugs have become one of the key areas of interest to researchers and drug manufacturers across the globe.

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XTalks

FEBRUARY 14, 2024

The extensive research in developing more effective and less toxic treatments, such as targeted therapies, immunotherapies and precision medicine , has helped to considerably improve the survival rates for many types of childhood cancers.

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Hormones Development Genetics Life Science 52

The Pharma Data

JANUARY 11, 2021

What’s more, this protective effect holds even if the person carries excess weight, researchers reported recently in the journal Nature Medicine. Bronfman Institute of Personalized Medicine with the Icahn School of Medicine at Mount Sinai, in New York City. It’s not yet clear why this link might exist, Cypess said.

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Scienmag

SEPTEMBER 15, 2020

Credit: Michigan State University Differences in biological sex can dictate lifelong disease patterns, says a new study by Michigan State University researchers that links connections between specific hormones present before and after birth with immune response and lifelong immunological disease development.

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Hormones Immune Response Development Research 78

pharmaphorum

DECEMBER 23, 2020

But there was some considerable progress in other fields of medicine even though research efforts were diverted away, reports Richard Staines. NT-814 is a non-hormonal drug that works on the neurokinin (NK) 1,3 receptor antagonist, thus treating the vasomotor symptoms associated with the menopause.

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XTalks

NOVEMBER 20, 2023

AstraZeneca has won its first-in-class approval for its AKT inhibitor Truqap (capivasertib) in combination with Faslodex (fulvestrant) for treating patients with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer.

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Scienmag

MAY 6, 2021

The findings presented today at EADV’s 2021 Spring Symposium, suggest that men with genetic characteristics (phenotypes) sensitive to the male sex hormone androgen, are more likely to experience severe COVID-19 disease. Researchers were driven […].

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Hormones Genetics Research Medicine 40

The Pharma Data

SEPTEMBER 3, 2020

Our new study offers an important basis from which to start developing new treatment strategies for a rare form of cancer, which starts in the hormone-producing cells of the pancreas,” noted Dr Anguraj Sadanandam, team leader in Systems and Precision Cancer Medicine at The ICR, London. “We

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XTalks

FEBRUARY 5, 2024

Why it did so well: In 2022, Avastin was Roche’s eighth best-selling drug, but as expected, the impact of biosimilars caused the sales of this cancer medicine to decrease by 28 percent compared to 2021. Price of Avastin: The cost of Avastin was reported to be £1,848.8 ($2,356.5 USD) per month for a 70 kg patient.

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Delveinsight

DECEMBER 29, 2020

Relugolix is a once-daily, oral gonadotropin-release hormone (GnRH) receptor antagonist. X-linked myotubular myopathy (XLMTM) is a rare genetic neuromuscular disorder and leads to muscle weakness, respiratory failure, and early death. mg and norethindrone acetate (0.5 mg) in the US and Canada.

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XTalks

AUGUST 15, 2023

Akeega is a dual-action tablet (DAT) that contains the company’s androgen receptor-targeting hormone therapy Zytiga (abiraterone acetate) and PARP inhibitor (poly [ADP-ribose] polymerase inhibitor) niraparib. Niraparib is also sold by GSK under the name Zejula in other indications.

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FDA Approval Gene Hormones Drugs 52

The Pharma Data

MAY 16, 2021

Of course, but you need the RIGHT ONE for your Specific Genetics. Now you can have the prefect outline to map out your diet to the letter, follow appropriate training suited for your genetic needs, and know exactly how to tailor cardio so you don’t eat up that precious muscle mass you have. And it doesn’t stop there.

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The Pharma Data

JUNE 24, 2021

The prognosis for men with advanced prostate cancer has significantly improved since the introduction of novel hormone therapies, but additional therapeutic options are needed for the approximately 25 percent of men with tumors harboring DNA damage response (DDR) gene mutations, who may have poorer outcomes,” said Chris Boshoff, M.D.,

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The Pharma Data

JUNE 24, 2021

The approval is supported by efficacy and safety data from the Phase 3 LIBERTY 1 and LIBERTY 2 studies, which were published in the New England Journal of Medicine. This is an important step forward as we seek to redefine care for women and for men, not only through new medicines but through continued collaboration with the community.” .

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The Pharma Data

DECEMBER 9, 2020

The new company, created by Hillhouse Capital Venture Partners, launched this week with a mission to pursue the most promising advances in medicine for underserved patients in Asia and around the world. A solution could be at hand with Overland Pharmaceuticals. Amolyt Pharma – France-based Amolyt Pharma and PeptiDream, Inc.

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XTalks

FEBRUARY 5, 2024

Why it did so well: In 2022, Avastin was Roche’s eighth best-selling drug, but as expected, the impact of biosimilars caused the sales of this cancer medicine to decrease by 28 percent compared to 2021. Price of Avastin: The cost of Avastin was reported to be £1,848.8 ($2,356.5 USD) per month for a 70 kg patient.

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FDA Approval Drugs Sales Development 52

XTalks

SEPTEMBER 11, 2024

“Failure to study medications and other interventions in a broad sampling has led to women experiencing adverse effects from medications at nearly twice the rate of men ,” says Dr. Jaclyn Jansen, MD, MS, Medical Director of the Medical Department, General Medicine, Medpace. It moves away from a one-size-fits-all approach ( Figure 2 ).

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WCG Clinical

OCTOBER 8, 2024

Latin America’s genetic diversity and unique health challenges are driving groundbreaking clinical research, offering new insights into disease prevention, innovative medicine, and treatments. For instance, compounds isolated from traditional medicinal plants have been developed into prescription medications.

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The Pharma Data

JUNE 18, 2021

lead study investigator of the Phase 3 RESONATE-2 trial, and Professor of Medicine at the Wilmot Cancer Institute, University of Rochester. IMBRUVICA ® is the only FDA-approved medicine in WM and cGVHD. IMBRUVICA ® was one of the first medicines to receive FDA approval via the Breakthrough Therapy Designation pathway.

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The Pharma Data

MAY 14, 2021

It’s the genetic master switch that controls our metabolism. Which is your #1 fat-storing hormone. It’s been tested in hundreds of different studies… And it has a long history of being used in traditional Chinese medicine…. Their waists got smaller… They also saw an improvement in fat-regulating hormones.

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XTalks

DECEMBER 22, 2021

RNA therapeutics hold promise as powerful treatments for diseases, including those that are genetic-based. They can provide continuous real-time monitoring of metabolites, bacteria, hormones, glucose and other elements in these fluids. RNA Therapeutics. The deal is worth $1.5 Prior to this, Lilly struck an agreement worth $1.25

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Life Science RNA Vaccination Vaccine 98

pharmaphorum

FEBRUARY 26, 2021

UK-based doctor, Dr Natasha Larmie is on a mission to make medicine weight inclusive. We would never use such a useless screening tool in any other area of medicine, so why do we still use BMI?” As a doctor, I think it is my responsibility to practice medicine fairly and without discrimination. Natasha says. “I

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The Pharma Data

DECEMBER 15, 2020

The project also seeks to engage the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) to identify opportunities for regulatory endorsement of such drug development tools. TOMI-T1D aims to create a clinical trial simulation tool (CTST) with large and diverse clinical datasets from the T1D community.

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Delveinsight

DECEMBER 2, 2020

Smoking – Cigarette smoking, coupled with the genetic factor, can increase the risk of developing Rheumatoid Arthritis. Hormones – It is observed that hormones differentially influence the onset of Rheumatoid Arthritis in premenopausal and postmenopausal women. However, the role of hormones is still unclear.

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XTalks

AUGUST 10, 2022

HER2 is a tyrosine kinase receptor that is overexpressed and genetically amplified in approximately 20 percent of breast cancers. The trial included 494 hormone receptor positive (HR+) patients and 63 hormone receptor negative (HR-) patients. The receptor is involved in promoting cell growth.

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FDA Approval HR Hormones Antibody 98