XTalks

SEPTEMBER 15, 2020

A vaccine developed by Swedish company Diamyd Medical has demonstrated significant treatment efficacy in a predefined genetic subgroup of individuals with type 1 diabetes in a Phase IIb clinical trial. Specifically, the vaccine contains human recombinant glutamate decarboxylase 65 (GAD65) protein conjugated to aluminum hydroxide (GAD-alum).

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XTalks

SEPTEMBER 17, 2020

Symptoms and Etiology: Caused by an overproduction of growth hormone, acromegaly primarily affects adults. By reducing the amount of growth hormone in the blood, progressive enlargement of bones should be slowed. By reducing the amount of growth hormone in the blood, progressive enlargement of bones should be slowed.

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Trials Gene Hormones Clinical Trials 98

The Pharma Data

JANUARY 7, 2021

He also noted innovations are occurring with protein degraders, antibody conjugates, nanobodies and multi-specific antibodies, specifically bi- and tri-specific. Another area where Sanofi is investing is through the Expanded Genetic Alphabet platform it gained at the end of 2019 through the $2.5 billion acquisition of Synthorx.

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Protein Antibody Genetics Gene Therapy 52

Delveinsight

AUGUST 31, 2021

FDA’s Green Flag to Ascendis’s Once-Weekly SKYTROFA for Treatment of Pediatric Growth Hormone Deficiency. Growth Hormone Deficiency , commonly known as dwarfism, can constitute short stature and complications with metabolism, which arise due to inadequate production of growth hormones by the pituitary gland inside the body.

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Roots Analysis

AUGUST 31, 2023

Further, the expression of any gene is dependent on the rate at which it is transcribed into mRNA and translated into proteins. There are various regulatory proteins or transcription factors that are responsible for affecting the transcription rate. These genetic switches assist transcription factors in binding to the promoter region.

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Delveinsight

JULY 30, 2020

Adrenoleukodystrophy (ALD/ X-ALD) is a rare, X-linked disorder secondary to a mutation in the ABCD1 gene, which encodes for a peroxisomal membrane protein, resulting in an excessive accumulation of very-long-chain fatty acids (VLCFAs) in the brain and adrenal glands. The disorder can occur at any stage of life and vary with severity.

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Hormones Marketing Gene Trials 52

XTalks

MARCH 13, 2024

Hormone-based therapeutics aim to delay glaucoma progression by enhancing estrogen’s potential protective effects. There are also studies examining gene therapy-based techniques to repair or replace genetic defects contributing to this disease.

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Gene Therapy Gene Life Science DNA 111

Delveinsight

AUGUST 6, 2020

Transthyretin (TTR) is a protein that the liver produces to facilitate the transfer of thyroid hormone and vitamin A in the blood. However, due to specific reasons, the TTR protein begins to misfold and aggregate as fibrils, a process known as amyloidosis of Transthyretin (ATTR). hATTR Market: Present Treatment Options.

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Protein Gene Silencing Marketing Gene 52

Roots Analysis

OCTOBER 24, 2023

This has led to their widespread production and extensive use in the treatment of various indications including hormonal imbalances, oncological disorders and respiratory disorders. The ADCs bind to specific proteins or peptides in cancer cells with very high specificity and efficacy influencing the biological functions.

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The Pharma Data

DECEMBER 31, 2020

The messenger RNA (mRNA) vaccines encode a form of the spike (S) protein of SARS-CoV-2 virus. The vaccine teaches the cells to make a piece of the spike protein, which triggers an immune response to help prevent illness if later exposed to the virus. The partial piece of the spike protein cannot cause COVID-19 disease.

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Vaccine Vaccination FDA Approval Hormones 52

XTalks

DECEMBER 22, 2021

RNA, and its protein-generating form messenger RNA (mRNA) discovered in 1961 , has quickly transitioned from being an obscure, finicky molecule that is difficult to work with, to becoming a significant cornerstone of therapeutic innovation in pharma and biotech. The RNA Revolution: From mRNA Vaccines to RNA Editing. RNA Therapeutics.

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Life Science RNA Vaccination Vaccine 98

Delveinsight

JANUARY 7, 2021

It also slates to commence a Phase Ib trial of its second candidate, TERN-201, a vascular adhesion protein (VAP-1) inhibitor, with top-line data anticipated in the first half of 2022. Terns schedules to bring a third candidate into the clinic this year, TERN-501, a thyroid hormone receptor (THR) beta-agonist.

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XTalks

MARCH 22, 2021

Using a simple, standard blood sample, the assay can detect actionable genetic mutations in cancers, including cancer-driving alterations. Maverick’s COBRA platform is used to engineer protein-based therapies that target T cells in the tumor microenvironment to trigger their activation.

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XTalks

MAY 10, 2023

The exact cause of lupus is not entirely understood, but it is thought to be from a combination of genetic, environmental and hormonal factors. It works by targeting a protein called B-lymphocyte stimulator (BLyS) that is overproduced in people with lupus and contributes to an overactive immune system.

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Drugs Clinical Trials Clinical Trials Antibody 52

XTalks

FEBRUARY 5, 2024

Sandostatin (Octreotide) Sandostatin 2022 sales: $1.238 billion Company/Developer: Novartis Date of first FDA approval: October 21, 1988 Indications Sandostatin is FDA-approved for: Sandostatin is a synthetic protein closely resembling the natural hormone somatostatin in the human body. mg implant) is around $1,006.

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FDA Approval Drugs Sales Development 101

The Pharma Data

MAY 15, 2021

Now imagine the entire length of the field as the 300,000 years of human genetic evolution. However your genetic code IS hardwired to go without food for short periods between times of plenty. What if there was a near “magical” fat burning hormone?… Especially meals that are high in sugar and protein.

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Production Hormones Protein Insulin 52

The Pharma Data

MAY 16, 2021

Of course, but you need the RIGHT ONE for your Specific Genetics. Now you can have the prefect outline to map out your diet to the letter, follow appropriate training suited for your genetic needs, and know exactly how to tailor cardio so you don’t eat up that precious muscle mass you have. And it doesn’t stop there.

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Production Hormones Genetics Vaccine 52

XTalks

FEBRUARY 5, 2024

Sandostatin (Octreotide) Sandostatin 2022 sales: $1.238 billion Company/Developer: Novartis Date of first FDA approval: October 21, 1988 Indications Sandostatin is FDA-approved for: Sandostatin is a synthetic protein closely resembling the natural hormone somatostatin in the human body. mg implant) is around $1,006.

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FDA Approval Drugs Sales Development 52

The Pharma Data

JUNE 18, 2021

The BTK protein sends important signals that tell B cells to mature and produce antibodies. VENCLEXTA ® /VENCLYXTO ® (venetoclax) is a first-in-class medicine that selectively binds and inhibits the B-cell lymphoma-2 (BCL-2) protein. VENCLXEXTA/VENCLYXTO targets the BCL-2 protein and works to help restore the process of apoptosis.

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Medicine Production FDA Approval Development 52

The Pharma Data

JUNE 18, 2021

The BTK protein sends important signals that tell B cells to mature and produce antibodies. 4 Genetics Home Reference. Isolated growth hormone deficiency. ? BTK signaling is needed by specific cancer cells to multiply and spread. European Heamtology Association 2021 Virtual Congress. November 2020. 5 Turetsky, et al.

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The Pharma Data

JUNE 18, 2021

The BTK protein sends important signals that tell B cells to mature and produce antibodies. About VENCLEXTA ® /VENCLYXTO ® (venetoclax) VENCLEXTA ® /VENCLYXTO ® (venetoclax) is a first-in-class medicine that selectively binds and inhibits the B-cell lymphoma-2 (BCL-2) protein. 5 Genetics Home Reference. 5 Burger JA et al.

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Medicine Production FDA Approval Development 40

The Pharma Data

MAY 14, 2021

Your body’s hormones are destroyed from almost a year of starvation. There are so many people out there telling you to try keto, intermittent fasting, vegan, high-protein, high-fat, low-fat, and so much more. Remember, I’m not genetically gifted in any way. One of the problems of anorexia is how it destroys your thyroid.

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The Pharma Data

MAY 14, 2021

It’s all based on human biology… I refer to it as your “metabolism switch”… But the scientific name for it is AMP-activated protein kinase…. It’s the genetic master switch that controls our metabolism. Which is your #1 fat-storing hormone. How little you exercise…. Because insulin BLOCKS AMPk.

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XTalks

AUGUST 10, 2022

HER2 is a tyrosine kinase receptor that is overexpressed and genetically amplified in approximately 20 percent of breast cancers. HER2-low is characterized by the presence of some HER2 proteins on the cell surface, but not enough to be classified as HER2-positive. The receptor is involved in promoting cell growth.

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FDA Approval HR Hormones Antibody 98

Delveinsight

DECEMBER 2, 2020

Smoking – Cigarette smoking, coupled with the genetic factor, can increase the risk of developing Rheumatoid Arthritis. Hormones – It is observed that hormones differentially influence the onset of Rheumatoid Arthritis in premenopausal and postmenopausal women. However, the role of hormones is still unclear.

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Marketing Hormones Antibody Development 60

The Pharma Data

JANUARY 21, 2021

They are now working to identify what genetic aberrations are causing ALS in about half of the Maltese patients. They found that by blocking the interaction of PGE2, a hormone, and a receptor, that it could restore the youthful metabolism in mouse and human myeloid cells in a Petri dish and in living mice.

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The Pharma Data

MAY 14, 2021

We have many hormones in our bodies, but when they are balanced they keep our bodies and our hair healthy. One of the most important hormones is Testosterone. While it is considered a men’s hormone, both men and women need it to grow and heal bones and muscles.

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Production Hormones Doctors Doctor 52

The Pharma Data

MAY 13, 2021

Following this program will help you lose weight fast, prevent yo-yoing, stabilize hormonal balance, and get back on track to leading a healthy life – all while never being hungry or having to go to the gym! Effects of glucose-to-fructose ratios in solutions on subjective satiety, food intake, and satiety hormones in young men.

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Insulin Production Hormones Medicine 52

Pharmaceutical Technology

JANUARY 22, 2023

The mutation leads to disordered thyroid hormone transport, which causes patients to experience intellectual and motor disabilities. Egetis is banking on tiratricol, an oral small molecule that restores dysfunctional thyroid hormone signalling, to be the first drug approved for this condition.

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Intouch Solutions

FEBRUARY 28, 2025

The exact reasons why rare diseases are more present in women than men are unknown, but some of the hypotheses include hormonal factors, genetic predisposition and womens stronger immune systems. Moreover, clinical data suggests that menstruation, pregnancy, and estrogen medication can worsen the symptoms in certain patients.

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