pharmaphorum

FEBRUARY 18, 2021

Researchers from the University of Texas Medical Branch based their findings on lab tests using SARS-CoV-2 coronaviruses that were genetically engineered to have the same mutations as those in the strain that is causing scientists so much concern.

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pharmaphorum

JULY 14, 2021

A few weeks ago, scientists in Germany said they had identified a possible mechanism behind the side effect related to the adenoviral vectors that both the AZ and J&J vaccines use to deliver the genetic code that stimulates the body to make the SARS-CoV-2 spike protein and stimulate an immune response.

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The Pharma Data

NOVEMBER 16, 2020

16, 2020 — Scientists are reporting early success with an experimental herpes vaccine that uses a genetically modified version of the virus. The gene edit prevents the virus from performing its normal evasive maneuver: hiding out in nervous system cells in order to elude the immune system. MONDAY, Nov.

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XTalks

MAY 30, 2023

It provides a powerful platform for individuals affected by MS to share their stories, for scientists to share their research and for advocates to push for more accessible and comprehensive healthcare. More than 200 genetic variants have been identified that are more common in people with MS.

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Genetics Research Immune Response Drugs 84

The Pharma Data

MARCH 8, 2022

Actually, these systems could identify viral genetic material (here: Ribonucleic acids/RNAs) and sound the alarm. In this way, the viral RNA escapes early recognition by the central antiviral immune-receptor RIG-I. Proteins of SARS-CoV-2 can alter viral ribonucleic acids in a way, that they become indistinguishable from endogenous RNA.

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Immune Response RNA Protein Genetics 52

Roots Analysis

MAY 21, 2024

LNPs comprise of a lipid bilayer that surrounds a hydrophobic core, which can be loaded with therapeutic agents ( such as drugs, genetic material and proteins ). Advantages of Lipid Nanoparticle LNPs are gaining significant attention of formulation scientists in drug delivery due to the various advantages offered by them.

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Drug Delivery Drugs Gene Therapy Bioavailability 40

Cloudbyz

MARCH 5, 2024

They are often used to mimic or enhance natural biological processes, such as immune responses. Immunogenicity : Small Molecules: Generally have a lower risk of inducing an immune response in the body. In this endeavor, collaboration between scientists, regulatory bodies, healthcare providers, and patients will be key.

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XTalks

FEBRUARY 19, 2024

The study compared the immune responses evoked by Moderna’s mRNA vaccine to those generated by a previous vaccine candidate, namely, the MF59-adjuvanted glycoprotein B (gB) proten subunit vaccine (gB/MF59) developed by Sanofi. Paduano Professor in Pediatrics at Weill Cornell Medicine, in a news release.

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Vaccination Vaccine Trials Clinical Trials 59

Delveinsight

FEBRUARY 11, 2021

Verily collaborates with Janssen to launch COVID-19 immune response study. Verily is partnering with Johnson & Johnson’s Janssen division to witness the body’s earliest immune responses to a coronavirus infection, with people participating in the research from within their homes. .

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Gene Therapy Gene Immune Response In-Vivo 52

pharmaphorum

MARCH 10, 2021

The study suggests that serum taken from patients injected with the mRNA shot, also known as BNT162b2, was able to neutralise a genetically engineered version of SARS-CoV-2 with the P.1 1 – that is worrying health officials around the world. . 1 mutations, as well as variants from the UK and South Africa.

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The Pharma Data

JUNE 1, 2022

Blocking an immune response-related enzyme holds promise in preventing or treating severe COVID-19 symptoms by reducing inflammation, tissue injury and blood clots in the lungs, new research in mice suggests. Previous research has shown that caspase 11 in mice has many of the same immune-response functions as caspase 4 in humans.

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Immune Response Genetic Engineering Engineer Research 52

The Pharma Data

OCTOBER 18, 2021

Northwestern Medicine scientists have shown for the first time that coronavirus vaccines and prior coronavirus infections can provide broad immunity against other, similar coronaviruses. The findings build a rationale for universal coronavirus vaccines that could prove useful in the face of future epidemics.

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Vaccination Vaccine Immune Response Antibody 40

The Pharma Data

MAY 27, 2022

The authorisation is based on a review by the Committee for Medicinal Products for Human Use (CHMP) of the substantial body of evidence demonstrating an increased immune response after a third dose booster with Vaxzevria following a primary vaccine schedule of either Vaxzevria or an mRNA COVID-19 vaccine.(1-5).

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Vaccination Vaccine Immune Response Medicine 52

The Pharma Data

JANUARY 21, 2021

22, 2021 — Everyone has heard the scary reports about the new, more infectious coronavirus variants that are circulating in countries around the world, but scientists aren’t pushing the panic button at this point. “The height of the antibody response may be somewhat proportional to how sick you are in the beginning. .”

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Vaccination Vaccine Protein Immune Response 52

The Pharma Data

JANUARY 13, 2021

The vaccine produced an immune response of all 805 clinical trial participants within two months of inoculation, according to results published Jan. The new vaccine is made up of a deactivated cold virus into which scientists cut-and-paste a genetic version of the “spike” protein used by the coronavirus to infect cells.

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Vaccination Vaccine Trials Immune Response 40

The Pharma Data

JULY 6, 2021

But HIV’s ability to mutate isn’t unique among RNA viruses – most viruses develop mutations, or changes in their genetic code, over time. They compared these sequences with the original SARS-CoV-2 genome, cross-checking the genetic changes against their highly networked epitopes. 1.351 Beta, P1 Gamma, and B.1.617.2

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Vaccine Vaccination Research Immune Response 52

The Pharma Data

DECEMBER 22, 2020

“There’s no reason to get scared or panic, we just need to closely monitor this variant,” said Dr. Ramon Lorenzo-Redondo, a scientist who studies COVID-19. Ison explained that “variants occur when there is a change in the genetic material of the virus that results in a change in proteins the virus makes.

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Vaccine Vaccination Immune Response Protein 52

The Pharma Data

JANUARY 5, 2021

Slaoui said earlier data showed that the vaccine appeared to rouse similar antibody responses among volunteers under age 55 who received either the full 100-microgram dose or a half dose. No evidence has been found that this variant is more deadly or causes more severe illness, and scientists are saying that the vaccines will work against it.

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Vaccination Vaccine Immune Response Trials 52

The Pharma Data

OCTOBER 28, 2020

“We continue to see the strongest effects in patients who are most at risk for poor outcomes due to high viral load, ineffective antibody immune response at baseline, or pre-existing risk factors. Yancopoulos , M.D., President and Chief Scientific Officer of Regeneron. Regeneron has shared these results with the U.S.

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The Pharma Data

DECEMBER 18, 2020

Action Follows Thorough Evaluation of Available Safety, Effectiveness, and Manufacturing Quality Information by FDA Career Scientists, Input from Independent Experts. The Moderna COVID-19 Vaccine contains messenger RNA (mRNA), which is genetic material. SILVER SPRING, Md. , 18, 2020 /PRNewswire/ — Today, the U.S.

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The Pharma Data

DECEMBER 29, 2020

The analysis was prospectively designed to focus on patients who had not yet mounted their own immune response to SARS-CoV-2 (i.e., did not have antibodies at baseline: seronegative), as prior evidence suggested these patients were at greater risk. futility analysis). .

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Antibody Trials Production Clinical Trials 52

The Pharma Data

NOVEMBER 20, 2020

The clinical evidence from Regeneron’s outpatient trial suggests that monoclonal antibodies such as casirivimab and imdevimab have the greatest benefit when given early after diagnosis and in patients who have not yet mounted their own immune response or who have high viral load.

Antibody 52

Antibody Production Clinical Trials Clinical Trials 52

Delveinsight

DECEMBER 3, 2020

AMD Patients often have low levels of CD59, which is a protein that protects the retina from damage caused by a vital part of the body’s natural immune response called complement. Scientists at Harvard Medical School have now proffered a light of hope that the ageing clock in the eye could be turned back, at least in animals.

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Gene Therapy Gene Antibody Research 52

The Pharma Data

DECEMBER 17, 2020

To develop this novel medicine, Regeneron scientists evaluated thousands of fully-human antibodies produced by the company’s VelocImmune ® mice, which have been genetically modified to have a human immune system, as well as antibodies identified from humans who have recovered from COVID-19.

Antibody 52

Antibody Medicine Production Trials 52

The Pharma Data

NOVEMBER 21, 2020

The clinical evidence from Regeneron’s outpatient trial suggests that monoclonal antibodies such as REGEN-COV2 have the greatest benefit when given early after diagnosis and in patients who have not yet mounted their own immune response or who have high viral load.

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The Pharma Data

JULY 6, 2021

PGRN is a key regulator of immune activity in the brain with genetic links to multiple neurodegenerative disorders, making it one of the most attractive genetically validated targets for the development of new immuno-neurology treatments. ” Arnon Rosenthal, Ph.D., ” Arnon Rosenthal, Ph.D.,

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Genetics Gene Antibody Development 52

XTalks

JUNE 10, 2024

The cause of psoriasis has yet to be fully understood, but scientists estimate its origins in genetic and environmental factors and immune dysregulation (where the body is unable to control its immune response). It is characterized by raised round or oval plaques lined with dry-looking silvery-white scales.

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Immune Response Dermatology Clinical Trials Clinical Trials 52

The Pharma Data

APRIL 8, 2021

Early clinical results are consistent with preclinical studies and suggest THOR-707 (SAR444245) may promote an anti-tumor immune response without alpha-mediated side effects, both alone and in combination with anti-PD-1.

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Immune Response Engineer Antibody Genetics 52

The Pharma Data

JANUARY 21, 2021

They are now working to identify what genetic aberrations are causing ALS in about half of the Maltese patients. How the Immune System Drives Brain Aging. Scientists at KU Leuven have identified a biological mechanism behind irritable bowel syndrome (IBS) and other food intolerances.

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pharmaphorum

OCTOBER 31, 2022

Yancopoulos continued: “Our scientists realised that the science demanded they adapt these technologies to deliver the first FDA-approved recombinant monoclonal antibody treatment for any viral disease, and they picked one of the most challenging ones in Ebola.”. Those technologies included the VelocImmune mouse and the VelociSuite.

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The Pharma Data

DECEMBER 31, 2020

Topol said that the United States does less genetic sequencing of virus to discover variants than other nations, and thus was probably slow to detect this new mutation. Greg Armstrong, who directs genetic sequencing at the CDC, told the AP. But a faster-spreading virus could swamp hospitals with seriously ill patients.

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Vaccination Vaccine Genetics Protein 52

XTalks

SEPTEMBER 14, 2020

It was recently reported that the addition of an adjuvant to their vaccine led to enhanced immune responses that exceeded responses in convalescent serum from symptomatic COVID-19 patients. Several laboratories have already shown that they can detect genetic material from the virus in wastewater.

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