Outsourcing Pharma

JULY 13, 2021

The genetic exome sequence analysis partnership has created a large database linking rare protein-coding genetic variants to human health and disease.

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Genetics Protein Research 98

Medical Xpress

FEBRUARY 21, 2025

Blood proteins serve as crucial indicators of health and disease risk throughout development.

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Protein Genetics Development Regulation 82

Scienmag

MAY 7, 2021

Credit: UPMC PITTSBURGH, May 7, 2021 – In a paper published today in Nature Communications, an international group of collaborators led by researchers at UPMC Children’s Hospital of Pittsburgh have identified a genetic cause of a rare neurological disorder marked by developmental delay and loss of coordination, or ataxia.

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Genetics Genetic Disease RNA Protein 95

Scienmag

APRIL 15, 2021

Team of Japanese and European scientists identify a novel genetic mitochondrial disorder by analyzing DNA samples from three distinct families Credit: Fujita Health University DNA ligase proteins, which facilitate the formation of bonds between separate strands of DNA, play critical roles in the replication and maintenance of DNA.

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Genetics DNA Genomics Genome 105

Pharmaceutical Technology

MAY 17, 2023

Antisense therapies are designed for destroying mRNA, reducing the amount of disease-causing protein. They will also have the potential to treat diseases that are caused by too little protein by increasing production, thus restoring the protein to normal levels.

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Scienmag

NOVEMBER 22, 2021

Scientist are now combining recent advances in evolutionary analysis and deep learning to build three-dimensional models of how most proteins in eukaryotes interact.

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Protein Scientist Genetics Medicine 90

Medical Xpress

MAY 4, 2023

A major challenge in human genetics is understanding which parts of the genome drive specific traits or contribute to disease risk. This challenge is even greater for genetic variants found in the 98% of the genome that does not encode proteins.

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Genetics Genomics Genome Protein 98

Pharmaceutical Technology

MARCH 11, 2024

is revolutionizing adoptive cell transfer therapies with patented methods to reduce HLA-A protein expression in engineered human cells. Discover how Intellia Therapeutics Inc. Explore the potential for treating cancer, infectious diseases, and autoimmune disorders.

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Protein Genetics Engineer 100

Medical Xpress

FEBRUARY 17, 2023

Researchers at the National Institutes of Health and their colleagues have found that a toxic protein made by the body called DUX4 may be the cause of two very different rare genetic disorders.

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Medical Xpress

APRIL 26, 2023

Researchers from Children's Hospital of Philadelphia (CHOP) and Princeton University have discovered a novel genetic disorder associated with neurodevelopmental differences. The study "Abrogation of MAP4K4 protein function causes congenital anomalies in humans and zebrafish" is published in Science Advances today, April 26.

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pharmaphorum

MARCH 26, 2021

There’s a new kid on the block among companies using artificial intelligence in drug discovery, after 1910 Genetics launched today with $26 million in financing. 1910 Genetics is named after the year in which sickle cell disease (SCD) was first discovered in the US by James Herrick.

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World of DTC Marketing

DECEMBER 29, 2020

These vaccines were developed using different “platform technologies” that involve slotting genetic material from the virus into a tried and tested delivery package. While such platform technologies are a non-traditional approach, that does not mean they are untested.

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Pharmaceutical Technology

DECEMBER 22, 2023

Enhance protein expression and cellular targeting for effective treatment of genetic disorders. Discover Amicus Therapeutics' groundbreaking gene therapy vectors and methods of use. Explore the patent claim now!

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Gene Therapy Protein Gene Genetics 100

Pharmaceutical Technology

FEBRUARY 20, 2023

Other lines of research look at the genetic overlap between FTD and amyotrophic lateral sclerosis (ALS), which could be used in the development of treatments for both conditions. This protein promotes lysosomal function. Proteins and biomarkers The pathologic buildup of proteins is also a potential drug target.

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Pharmaceutical Technology

JUNE 24, 2022

The protein-based vaccine is engineered from the genetic sequence of the SARS-CoV-2 virus’ initial strain. Developed utilising Novavax’s recombinant nanoparticle technology to generate antigen obtained from the coronavirus spike (S) protein, the vaccine is also formulated with the company’s saponin-based Matrix-M adjuvant.

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Pharmaceutical Technology

JULY 6, 2022

A protein-based vaccine, NVX-CoV2373 is made from the genetic sequence of the SARS-CoV-2 virus’ first strain. Our protein-based vaccine was developed using an innovative approach to traditional technology and has demonstrated efficacy and safety in both adolescents and adults.”.

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Scienmag

MARCH 30, 2022

Russian researchers and their international collaborators have developed a full-function bioelectronic photocell using one molecule of a fluorescent protein attached to a carbon nanotube. The […].

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Protein Genetics Development Research 69

STAT News

APRIL 10, 2023

So we were excited when we were referred to a pediatric geneticist who offered Gabrielle whole exome sequencing , which sequences all of the protein-coding regions of the genome, to determine whether there was a genetic cause. Read the rest…

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Genetics Genomics Genome Protein 98

Medical Xpress

MARCH 29, 2025

Alopecia is an autoimmune disorder that causes non-scarring hair loss on the scalp and body that is experienced by almost 2% of the global population at some point in their lifetime.

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Protein Genetics 141

Worldwide Clinical Trials

AUGUST 14, 2024

Historically, these indications have challenged the one-size-fits-all treatment approach due to patient variability, such as genetic differences in drug metabolism and underlying health conditions. This resistance may occur due to genetic mutations, epigenetic changes, or a tumor’s microenvironment.

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Pharmaceutical Technology

MARCH 28, 2024

Discover how 4D Molecular Therapeutics Inc's patented variant AAV capsid proteins enhance muscle cell infectivity for gene therapy, revolutionizing treatment for genetic disorders.

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Medical Xpress

DECEMBER 5, 2022

Biomedical and genetic engineers at Duke University and the Albert Einstein College of Medicine have designed a small fluorescent protein that emits and absorbs light that penetrates deep into biological tissue.

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Protein Genetic Engineering Research Engineer 75

Worldwide Clinical Trials

APRIL 15, 2025

Despite their clinical heterogeneity, these diseases often share overlapping pathological mechanisms, including protein misfolding and aggregation, synaptic dysfunction, neuroinflammation, and axonal degeneration. Elevated NfL levels in CSF and serum correlate with disease activity, brain atrophy, and long-term disability.

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Clinical Trials Clinical Trials Trials Protein 100

Medical Xpress

MAY 15, 2023

Irregularities in the body's genetic coding to make proteins are linked to cancerous tumors. But most genetic material contains elements whose function isn't clear.

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Pharmaceutical Technology

SEPTEMBER 5, 2022

Administered as a single dose, the genetically engineered vaccine has the replication-defective adenovirus type 5 vector that expresses the spike S protein of the SARS-CoV-2 virus. In May, CanSinoBIO received an emergency use listing (EUL) from the World Health Organization (WHO) for its recombinant Covid-19 shot, Convidecia.

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XTalks

JULY 26, 2021

But several researchers and experts have brought to light some food safety concerns of plant-based meat, and why it must be treated differently than that of animal protein. Because of their near-neutral pH and high protein and moisture content, plant-based meats are susceptible to microbial growth. Subject to Microbial Growth.

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Pharmaceutical Technology

FEBRUARY 22, 2023

Taldefgrobep is a complete human anti-myostatin recombinant protein that is developed for lowering free myostatin. According to Biohaven, SMA affects nearly one in 11,000 births in the US, and it is a genetic carrier in approximately one in every 50 Americans.

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Clinical Trials Clinical Trials Genetics Protein 246

Pharma Times

JUNE 27, 2021

The vaccine has been designed with minor genetic alterations to the spike protein based on the beta (B.1.351) 1.351) variant

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Medical Xpress

MARCH 18, 2023

University of Utah Health scientists have corrected abnormal heart rhythms in mice by restoring healthy levels of a protein that heart cells need to establish connections with one another.

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Gene Therapy Protein Genetics Gene 110

Scienmag

APRIL 19, 2022

Eukaryotes (from the Greek meaning “true kernel”) have a cell nucleus that harbours most of the cell’s genetic information and includes organisms such as humans, plants and fungi. In prokaryotes, the cell’s contents, including its genetic material, are diffusely distributed. Eukaryotes typically have much larger […].

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Protein Scientist Genetics 83

Scienmag

MARCH 9, 2022

The genome also has the code for making a capsid, the protein shell of a virus that encapsulates the genome and protects it like a nanocontainer. . — Each simple RNA virus has a genome, its “native RNA.” This genome dictates how the virus replicates in cells to eventually cause disease. Credit: Zandi lab, […].

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Packaging Packaging Genetics Genomics 84

Pharmaceutical Technology

JULY 12, 2022

A protein-based vaccine, NVX-CoV2373 is created from the genetic sequence of the SARS-CoV-2 virus’ initial strain. It is formulated with the company’s saponin-based Matrix-M and also comprises a purified protein antigen.

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Scienmag

NOVEMBER 25, 2020

An international study, coordinated by experts from the University of Nottingham, has revealed that the genetic risk of pre-eclampsia – a potentially dangerous condition in pregnancy – is related to blood pressure and body mass index. It […].

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Genetics Protein Medicine 73

Medical Xpress

FEBRUARY 14, 2025

Researchers from Cologne, Bochum, Padova and Angers have discovered a novel connection between mitochondrial function, protein quality control and cellular health, whose failure could be the leading cause of the currently incurable neurological disease Charcot-Marie-Tooth (CMT).

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Protein Research Genetics 82

Scienmag

JULY 2, 2021

Studies using human cell lines and tumors grown in mice provide early evidence that inhibiting RNA-binding proteins, a previously overlooked family of molecules, might provide a new approach for treating some cancers Credit: UC San Diego Health Sciences In cancer research, it’s a common goal to find something about cancer cells — some sort (..)

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RNA Protein Drugs Research 87

Medical Xpress

DECEMBER 1, 2022

A University of Massachusetts Amherst scientist has discovered that a mutation in the misfolding protein that causes Parkinson's disease offers protection against another fatal neurodegenerative disorder—multiple system atrophy (MSA), which is caused by the same misfolding protein.

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Protein Scientist Genetics 75

Pharmaceutical Technology

JUNE 15, 2023

Eloxx is conducting a Phase II trial (NCT05448755) investigating ELX-02 in the treatment of Alport syndrome – a genetic disorder characterised by kidney disease. ELX-02 is a small molecule drug designed to increase the probability full-length proteins are produced by promoting ribosomal function.

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