pharmaphorum

FEBRUARY 3, 2021

“A recent report indicates that autologous T cells that carry multiple CRISPR-Cas9-mediated genetic modifications designed to improve persistence and efficacy can be safely administered to patients with refractory cancer, providing an important step forward in the use of CRISPR in immune cell therapies”.

Gene Editing 98

Gene Editing Gene DNA Engineer 98

XTalks

JANUARY 21, 2025

There, plasma is separated, and tumor DNA is identified by detecting genetic mutations, methylation patterns and fragmentation signals. The Onclarity HPV reagent pack extraction combo. The genetic bleeding disorder is caused by the absence of blood clotting factor IX. Photo courtesy of BD.

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FDA Approval Manufacturing Development RNA 105

Scienmag

MAY 18, 2021

(Boston)–Researchers from Boston University School of Medicine (BUSM) report the formation of human cells containing a green fluorescent protein or GFP (one of the most important proteins in biology and fluorescence imaging) genetically fused with two interferon stimulated genes (ISGs), namely Viperin and ISG15.

Immune Response 41

Immune Response Reagent Research Protein 41

Pharmaceutical Technology

SEPTEMBER 1, 2022

While nucleic acid amplification tests - a type of viral diagnostic test for a virus or bacterium that detects genetic materials rather than antigens or antibodies - can provide a shorter turnaround time, they come with challenges, ranging from their complex nature to the intensity of labour required in their creation. “For

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Manufacturing Bacterium Reagent Production 130

The Pharma Data

OCTOBER 27, 2020

.” With the panel’s authorization, Agena also aims to alleviate material shortages, enabling laboratories to accelerate testing without concerns about instrument or reagent availability. Agena Bioscience develops, manufactures, and supplies genetic analysis systems and reagents, including the MassARRAY ® System.

Genetic Analysis 52

Genetic Analysis Genome Genomics Reagent 52

Camargo

MAY 2, 2021

In chimeric antigen receptor T-cell (CAR-T) therapy, cells are genetically modified before being (re)introduced into the patient, representing the intersection between gene and cell therapy. Both have tremendously evolved in recent years. Identify critical development issues or deficiencies to address.

Gene Therapy 155

Gene Therapy Gene Packaging Packaging 155

Roots Analysis

FEBRUARY 13, 2023

It transfers genetic information form to DNA to ribosomes, a specialized structure, or organelle, which decodes genetic information into a protein. With the help of genetic engineering, synthetic mRNAs can express proteins, as they structurally resemble a natural mRNA.

Manufacturing 52

Manufacturing Drug Delivery Systems Genetic Engineering RNA 52

Roots Analysis

FEBRUARY 21, 2022

Moreover, the manual protocols require extensive manipulation, costly reagents and long duration of skilled genomic library production. The evolution of NGS technologies has made it possible to sequence thousands of genes with a suspected genetic disease predisposition, in a very short period of time and at minimal costs.

Marketing 52

Marketing Gene Sequencing DNA Genome 52

The Pharma Data

JANUARY 31, 2021

It will offer chosen startups with access to investment and business guidance from Sequoia Capital China, and access to Illumina’s sequencing systems, reagents and genomics expertise. The new incubator will have two funding cycles per year, each six months long. All will be in a fully operational laboratory space in Shanghai, China.

Life Science 52

Life Science Genome Genomics Reagent 52

The Pharma Data

SEPTEMBER 8, 2021

TIB Molbiol is a biotech company that has supplied the global market with reagents for research and medical diagnostics for over 30 years.

Genotype 52

Genotype Reagent Genetics Research 52

Roots Analysis

OCTOBER 16, 2023

These genes possess the following characteristics: GC content: Moderate (40-65%) No critical hairpin loops Not more than 20 bp repeats Not more than 20bp hairpin stretches Complex Genes: The interaction of a gene with external factors, either environmental or genetic, influences the normal trait, making it complex.

DNA 40

DNA Gene Protein In-Vitro 40

The Pharma Data

MARCH 16, 2022

3, and Delta ([link] About TIB Molbiol TIB Molbiol is a subsidiary of Roche Diagnostics that has supplied the global market with reagents for research and medical diagnostics for over 30 years. These kits can detect and differentiate between Omicron subvariants BA.1,

In-Vitro 52

In-Vitro Genotype Reagent Protein 52

Advarra

NOVEMBER 29, 2022

Bottlenecks in the manufacturing process, supply chain issues such as accessibility of good manufacturing practice (GMP)-grade reagents, and shortages of qualified scientists and engineers have caused many therapies to fail at critical stages of the clinical development pipeline. But review issues are not the only problems.

Gene Therapy 52

Gene Therapy Gene Production Clinical Trials 52

FDA Law Blog

MAY 19, 2023

The submission will need to include a “detailed description of a protocol for continuous monitoring, identification, and handling of genetic mutations and/or novel isolates or strains.” Continuous Monitoring and Post Market Reporting Special Controls Within the Special Control for Risk Analysis are details regarding continuous monitoring.

Reagent 40

Reagent Genetics Contamination Marketing 40

The Pharma Data

MARCH 13, 2021

HAE is a rare genetic disorder that results in recurrent attacks of oedema – swelling – in various parts of the body, including the abdomen, face, feet, genitals, hands and throat. The reagents used in the aPTT laboratory test initiate intrinsic coagulation through the activation of plasma kallikrein in the contact system.

Drugs 52

Drugs Antibody Production Medicine 52

XTalks

OCTOBER 19, 2023

This could involve tweaking experimental conditions, changing reagents or redesigning the assay. There is also an increasing focus on personalized and precision medicine, where treatments are tailored to individual patients based on genetic or molecular data, which requires assays to detect and quantify these unique markers.

Scientist 59

Scientist Development Research Compliance 59

The Pharma Data

JULY 11, 2021

Hereditary angioedema (HAE) is a rare genetic disorder that results in recurring attacks of oedema – swelling – in various parts of the body, including the abdomen, face, feet, genitals, hands and throat. About Hereditary Angioedema. The swelling can be debilitating and painful. 7,8 HAE affects an estimated 1 in 50,000 people worldwide.

Allergies 52

Allergies Antibody Recombinant DNA Technology Production 52

XTalks

OCTOBER 1, 2020

Sooter has also found success in industry, leading and bringing together the work of different teams of researchers at NeuBase to help drive the company’s goal of developing cures and treatments for genetic diseases, including Huntington’s Disease. She says, “It’s been a lot of fun; it’s a decision I’m glad I made.”.

Scientist 52

Scientist In-Vitro Research Life Science 52

The Pharma Data

JANUARY 20, 2021

Laboratory Implementation Laboratory reagents for performing the test commercially have been designed and are currently being validated in preparation for regulatory submission to CMS/CLIA with a view to targeting sales in the USA initially. MELBOURNE, Australia, Jan. Quarterly Results Release Date and Webinar.

Genetics 40

Genetics Reagent Biobanking Production 40

XTalks

JANUARY 6, 2025

Furthermore, CRISPR/Cas9 presents a promising avenue for overcoming genetic diseases in the near future. CAR-T cell therapies continue to dominate the pipeline for genetically modified cell therapies, with 97 percent of them targeting cancer. By 2025 , 10 to 20 new gene therapies are expected to gain approval each year.

Gene Therapy 111

Gene Therapy RNA Gene Editing Gene 111