Scienmag

APRIL 26, 2022

Using new analyses, scientists have just found the last two of the five informational units of DNA and RNA that had yet to be discovered in samples from meteorites. While it is unlikely that DNA could be formed in a meteorite, this discovery demonstrates that these genetic parts are available for delivery and could have […].

DNA 86

DNA RNA Genetics Scientist 86

Scienmag

MARCH 4, 2021

Findings explain how plants use RNA to defend against fungal invaders Credit: Nicole Ward Gauthier/University of Kentucky New research reveals an essential step in scientists’ quest to create targeted, more eco-friendly fungicides that protect food crops.

Protein 95

Protein RNA Scientist Manufacturing 95

Scienmag

NOVEMBER 6, 2020

JUPITER, FL–A new strategy for treating a variety of diseases known as RNA-repeat expansion disorders, which affect millions of people, has shown promise in proof-of-principle tests conducted by scientists at […].

RNA 60

RNA Scientist Research Genetics 60

Scienmag

NOVEMBER 20, 2020

Scientists at Goethe University within the international consortium COVID19-NMR refine previous 2D models The genetic code of the SARS-CoV2 virus is exactly 29,902 characters long, strung through a long RNA molecule. It contains the information for the production of 27 proteins.

Genome 70

Genome Genomics RNA Protein 70

The Pharma Data

FEBRUARY 22, 2022

State-of-the-art facility will headquarter research efforts in Boston and New York to accelerate the development of RNA and DNA-based medicines. Adams, vice president of genetic medicine at Lilly and co-director of the Institute. ” The Institute will be headquartered in 334,000 sq.

Genetics 52

Genetics Medicine RNA Scientist 52

The Pharma Data

JUNE 14, 2023

Scientists discover small RNA that regulates bacterial infection People with weakened immune systems are at constant risk of infection. Using genetic sequencing technologies, Whiteley and Cao measured the levels of all types of mRNA present in the bacteria. They named the small RNA SicX (sRNA inducer of chronic infection X).

RNA 40

RNA Regulation Scientist Bacteria 40

The Pharma Data

NOVEMBER 17, 2021

Mount Sinai researchers have developed a new model that uses DNA and RNA sequencing data from hundreds of patients to identify specific genes and genetic alterations responsible for never-before-defined subtypes of a blood cancer called multiple myeloma. doi: 10.1126/sciadv.abg9551. Source link: [link].

Scientist 52

Scientist RNA DNA Genetics 52

Pharmaceutical Technology

JULY 5, 2022

In addition, the scientists later found that the HAV needs TENT4A/B for its replication. It was also found in lab experiments that ZCCHC14, a protein that interacts with zinc, attaches to certain part of HAV’s ribonucleic acid (RNA), enabling the virus to recruit TENT4 from the human cell.

Protein 130

Protein RNA Genome Genomics 130

XTalks

DECEMBER 14, 2022

It’s a new genetic way of potentially targeting these really hard to treat diseases,” said Abudayyeh, a McGovern Fellow at MIT’s McGovern Institute for Brain Research, in MIT’s press release. Integrases are used by viruses called bacteriophages to insert their genetic material into bacteria. How does the Gene Editing Tool PASTE Work?

Gene Editing 98

Gene Editing DNA Gene Gene Sequencing 98

Scienmag

JANUARY 18, 2021

19, 2021) – A look at RNA tells us what our genes are telling our cells to do, and scientists say looking directly at the RNA of brain tumor cells appears to provide objective, efficient evidence to better classify a tumor and the most effective treatments. […].

RNA 52

RNA Gene Scientist Genetics 52

Scienmag

DECEMBER 22, 2020

Credit: Kung-Chi Chang/Spector lab, 2020 Cold Spring Harbor Laboratory (CSHL) scientists have discovered a gene-regulating snippet of RNA that may contribute to the spread of many breast cancers. The same strategy, […].

RNA 52

RNA Gene Scientist Regulation 52

XTalks

AUGUST 29, 2022

CRISPR is notable for engineering living cells, allowing scientists to edit, turn off, delete, or replace genes in a cell’s genome. The CRISPR-Cas9 system works by having “spacer” sequences transcribed into short RNA sequences that can guide the system to the matching target in the DNA sequence of a cell.

Gene Editing 98

Gene Editing DNA Gene Genome 98

Scienmag

NOVEMBER 16, 2020

Singapore scientists uncover potential role of long non-coding RNAs in pancreatic cancer Credit: From Figure 4 in Liu, S., doi:10.1186/s13073-020-00788-5… SINGAPORE, 3 Nov 2020 – Long RNA molecules carrying DNA codes that […]. Harmston, N., Glaser, T.L. Genome Med 12, 89 (2020). Genome Med 12, 89 (2020).

In-Vivo 53

In-Vivo RNA DNA Genome 53

Scienmag

NOVEMBER 1, 2020

Scientists from an international group led by the RIKEN Center for Integrative Medical Sciences and Yokohama City University have discovered that a pair of proteins play a key role in allowing an important type of functional non-coding RNA, known as SINEUPs, to act to promote their target messenger RNA.SINEUPs are a recently discovered type of […]. (..)

Protein 45

Protein Production RNA Research 45

Scienmag

FEBRUARY 17, 2021

Messenger RNA (mRNA) vaccines to prevent COVID-19 have made headlines around the world recently, but scientists have also been working on mRNA vaccines to treat or prevent other diseases, including some forms of cancer.

Vaccine 40

Vaccine Vaccination RNA Scientist 40

XTalks

APRIL 6, 2022

Scientists at the University of Cambridge evaluated the use of a personalized blood test that detects ctDNA to help predict the relapse risk of lung cancer. XTALKS WEBINAR: Using CRISPR interference (CRISPRi) Viability Screens to Map Long Noncoding RNA Dependencies in Tumor Cells.

DNA 105

DNA In-Vitro Doctors Doctor 105

The Pharma Data

SEPTEMBER 28, 2020

The large-scale project, undertaken in collaboration with researchers and clinicians from Fred Hutchinson Cancer Research Center (Fred Hutch) and the Target Padiatric AML (TpAML) computational working group aims to enable paediatric oncology physicians and researchers to better analyse patient clinical trial and genetic data.

Genome 52

Genome Genomics Clinical Trials Clinical Trials 52

The Pharma Data

NOVEMBER 22, 2020

Scientists in Israel have used the CRISPR Cas-9 gene editing system to destroy cancerous cells in mice without damaging other cells. To conduct the research, the scientists used hundreds of mice with two of the most aggressive forms of cancer: glioblastoma and metastatic ovarian cancer. Photo courtesy of Science Advances.

Gene Editing 52

Gene Editing DNA Genome Genomics 52

The Pharma Data

MARCH 23, 2022

Now scientists at La Jolla Institute for Immunology (LJI) and Scripps Research have found a promising strategy for stopping Ebola virus polymerase. The major challenge in developing drugs directly against Ebola virus polymerase is that scientists have not solved its atomic structure.

Protein 52

Protein Genome Genomics Research 52

The Pharma Data

JULY 6, 2021

But HIV’s ability to mutate isn’t unique among RNA viruses – most viruses develop mutations, or changes in their genetic code, over time. They compared these sequences with the original SARS-CoV-2 genome, cross-checking the genetic changes against their highly networked epitopes. 1.351 Beta, P1 Gamma, and B.1.617.2

Vaccine 52

Vaccine Vaccination Research Immune Response 52

The Pharma Data

JANUARY 13, 2021

.” The Johnson & Johnson vaccine also would be hardier than either of the already approved vaccines because it relies on DNA technology rather than messenger RNA to prompt an immune system response. The new vaccine remains stable for a time in the refrigerator.

Vaccine 40

Vaccine Vaccination Trials Immune Response 40

pharmaphorum

JANUARY 26, 2023

We are already seeing an increase in projects exploring population genomics in Africa, the Middle East, and Asia, with initiatives including the GenomeAsia100K Project and the Genome Aggregation Database focusing on capturing genetic data of non-European individuals. Just one mutation can lead to a complete change in protein formation.

Genome 129

Genome Genomics Genome Project Genetics 129

Pharmaceutical Technology

APRIL 20, 2023

Targovax has unveiled plans to rebrand as Circio , reflecting its strategic shift to focus on expediting the development of its innovative circular RNA (circRNA) platform. Initially reported in 2011, CircRNA is a naturally occurring class of RNA.

Gene Therapy 240

Gene Therapy RNA Gene Development 240

XTalks

OCTOBER 8, 2024

The 2024 Nobel Prize in Physiology or Medicine has been awarded to American scientists Victor Ambros and Gary Ruvkun for their groundbreaking discovery of microRNA (or miRNA) and its role in post-transcriptional gene regulation. A gene contains instructions within our DNA. The work, which began in the early 1990s through studies on the C.

Regulation 52

Regulation Genetics Scientist RNA 52

NY Times

JANUARY 26, 2021

Scientists are exploring the physics of viruses, to understand how these pathogens assemble themselves — and might be rent apart.

Scientist 70

Scientist RNA Protein Genetics 70

XTalks

OCTOBER 21, 2020

The answer may lie in the genetic code of the virus, which scientists at Duke University have found contains several silent mutations that affect protein folding. Moreover, Berrio says the changes likely affected the folding and function of viral RNA. So studying the genetics of the current coronavirus strain remains important.

RNA 98

RNA Protein Genome Genomics 98

pharmaphorum

JANUARY 22, 2021

According to the US biopharma company, genetic analyses of publicly available sequences for the new variants of SARS-CoV-2 suggest the mutations in the viral spike protein that have made them more transmissible shouldn’t affect the way Veklury (remdesivir) works.

In-Vitro 141

In-Vitro RNA Licensing Licensing 141

XTalks

MAY 4, 2021

Researchers at the University of California San Francisco (UCSF) and the Whitehead Institute have developed a novel CRISPR-based tool called “CRISPRoff” that can switch off genes in human cells through epigenetic editing without altering the genetic sequence itself. Epigenetic Editing with CRISPR.

DNA 98

DNA Gene Gene Silencing Genome 98

pharmaphorum

NOVEMBER 9, 2020

The vaccine is based on a strand of messenger RNA – a short segment of genetical material that codes for the “Spike” protein found on the surface of the coronavirus. Around 42% of global participants and 30% of U.S. participants have racially and ethnically diverse backgrounds.

Vaccine 98

Vaccine Vaccination Clinical Trials Clinical Trials 98

The Pharma Data

MAY 9, 2022

But now Northwestern Medicine scientists, in an international collaboration with scientists at the University of California, San Francisco and the University of Hong Kong, have identified a drug that inhibits growth of the most aggressive meningiomas and how to most accurately identify which meningiomas will respond to the drug.

Drugs 52

Drugs Scientist DNA Genetics 52

Pharma Mirror

APRIL 21, 2024

This represents an increasingly promising field of precision medicine, holding significant prospects for preventing and treating numerous challenging or genetic diseases. Scientists have been striving to optimize mRNA stability, immunogenicity, translation efficiency, and delivery systems to achieve efficient and safe mRNA delivery.

In-Vitro 130

In-Vitro Drugs Genetic Disease RNA 130

XTalks

MAY 4, 2021

Researchers at the University of California San Francisco (UCSF) and the Whitehead Institute have developed a novel CRISPR-based tool called “CRISPRoff” that can switch off genes in human cells without editing the genetic sequence itself. These modifications regulate gene expression without altering the sequence or structure of DNA. .

DNA 52

DNA Gene Gene Silencing Genome 52

XTalks

MARCH 8, 2022

With exciting new applications being developed in the areas of gene therapy, CRISPR and RNA editing, the contributions of women to these fields was highlighted in a piece we published last year on women scientists who paved the way forward in genetics.

Life Science 105

Life Science Gene Therapy DNA Vaccine 105

Delveinsight

FEBRUARY 25, 2021

Beam Therapeutics has taken over a startup whose technology could proffer the biotech’s genetic medicines to more tissues in the body, widening the potential to approach more diseases. Cambridge, Massachusetts-based Beam aims to make more precise edits with genetic medicines, which employ base-editing.

DNA 52

DNA In-Vivo Genetics Medicine 52

Scienmag

SEPTEMBER 30, 2020

Scientists are fighting back with multiple strategies, including vaccines, repurposed drugs developed for other diseases and brand-new therapies. Now, researchers reporting in ACS Central Science have identified small molecules that target a structure within the RNA genome […].

RNA 40

RNA Genome Genomics Branding 40

The Pharma Data

JANUARY 21, 2021

22, 2021 — Everyone has heard the scary reports about the new, more infectious coronavirus variants that are circulating in countries around the world, but scientists aren’t pushing the panic button at this point. FRIDAY, Jan. Because the new COVID-19 vaccines should still work on these viral interlopers.

Vaccine 52

Vaccine Vaccination Protein Immune Response 52

The Pharma Data

DECEMBER 18, 2020

Action Follows Thorough Evaluation of Available Safety, Effectiveness, and Manufacturing Quality Information by FDA Career Scientists, Input from Independent Experts. The Moderna COVID-19 Vaccine contains messenger RNA (mRNA), which is genetic material. SILVER SPRING, Md. , 18, 2020 /PRNewswire/ — Today, the U.S.

Vaccine 52

Vaccine Vaccination Production Manufacturing 52