pharmaphorum

JANUARY 18, 2023

However, the Resilience Project’s scientists had used genomic data originally collected for other studies and, due to limitations in the original studies’ informed consent policies and a lack of infrastructure to recontact participants, none of the 13 individuals could be contacted with follow-up questions or requests.

Genetic Disease 97

Genetic Disease Genetics Research Genome 97

Scienmag

JUNE 23, 2022

Recent African genome-wide association studies (GWAS) for OFCs identified 170 near significant SNPs (p=10-5). 170 GWAS derived SNPs were genotyped on 3000 replication samples from participants in Ethiopia, Ghana, and […].

Genotype 58

Genotype Genome Genomics Development 58

pharmaphorum

JANUARY 29, 2019

How the shift towards cancer as a phenotype/genotype is being applied in clinical trials and how they are run •What are co-clinical trials and why could they hold the key to answering unmet need in cancer treatment and beyond into broader drug development? •Personalised medicine in practice – where are we now in cancer?

Genome 52

Genome Genomics Medicine Clinical Trials 52

Worldwide Clinical Trials

FEBRUARY 6, 2023

As genome-wide association studies to identify genetic markers for common diseases increase, these questions will surface even more. The best course of action will depend on many variables, such as the disease or population being studied and the genotype/phenotype relationship, risk, and impact on care.

Genetics 130

Genetics Clinical Trials Clinical Trials Genotype 130

Bioengineer

JANUARY 16, 2024

not reached) in genomic analysis of post-progression samples from patients receiving second-line osimertinib. Importantly, a triple mutant scenario with EGFR L858R/T790M/C797S or EGFRexon19del/T790M/C797S genotype may occur in patients with T790-positive NSCLC receiving osimertinib in second or later lines. months, 95% CI 1.3,

Genome 119

Genome Genomics Protein In-Vitro 119

Roots Analysis

AUGUST 31, 2023

Nutrigenomics is the science studying the relationship between human genome, nutrition and health. In part, the success of the Human Genome Project has also paved a path for the novel concept of nutrigenomics. It further highlights the variation in the genome of patients and identify the sites of metabolic weakness.

Genome 40

Genome Genomics Genetics Gene 40

Worldwide Clinical Trials

DECEMBER 12, 2022

genotyping for known variants vs sequencing only vs sequencing and concurrent deletion/duplication analysis), and whether the interpretation of the genetic testing results may have changed over time. Why is the turnaround time for whole-genome sequencing and whole-exome sequencing (WES/WGS) longer than a single-gene or panel test?

Clinical Trials 130

Clinical Trials Clinical Trials Genetics Trials 130

XTalks

APRIL 15, 2021

New advances in heart failure genomics are helping to address this challenge. Experts from Servier and Genuity Science recently spoke on a webinar about using genomics data to drive drug development in heart failure and identify new targets for novel therapeutics. Watch this on-demand webinar to hear from these experts.

Development 97

Development Drugs Genome Genomics 97

The Pharma Data

NOVEMBER 18, 2020

from Cedars-Sinai Medical Center in Los Angeles, and colleagues used whole-exome sequencing and genome-wide genotyping to determine the proportion of 792 IBD patients genetically at risk for TED and investigate the effect of the genetic risk for TED in IBD. WEDNESDAY, Nov. 21 in Gastroenterology. Takeo Naito, Ph.D.,

Genetics 52

Genetics Genotype Genome Genomics 52

pharmaphorum

AUGUST 11, 2022

There have been great strides made in genomics to refine tools that determine the safest, most effective course of treatments for patients across a number of disease states. Looking at an individual’s genomic profile also provides an understanding of appropriate medication dosage.

Genome 98

Genome Genomics Drugs Genetics 98

pharmaphorum

JANUARY 24, 2023

The cost of testing per human genome in 2006 was approximately $14 million , and in less than two decades, an average consumer-purchased genetic test costs $100. The same is becoming true for the healthcare industry, and one of the first major breakthroughs in the area was the 100,000 Genomes Project.

Genetics 98

Genetics Drugs Genome Project Biobanking 98

Roots Analysis

AUGUST 12, 2024

Molecular diagnostic tests are advanced techniques and tools used to analyze biological markers in the genome and proteome. Molecular diagnostic tests refer to tests intended to detect specific sequences in human genomic samples, such as DNA or RNA, in order to diagnose a particular disease. What are Molecular Diagnostic Tests?

Genetics 40

Genetics Gene Expression RNA DNA 40

Delveinsight

DECEMBER 13, 2020

Hepatitis C treatment options, without a doubt, have improved significantly, including pan-genotypic medications that are used to treat all genotypes and subtypes. Typically, pan-genotypic treatments have high cure rates, few side effects, and short treatment durations (usually 8–12 weeks). and GT2 and GT3 with ribavirin.

Genotype 52

Genotype FDA Approval DNA Drugs 52

Advarra

FEBRUARY 28, 2023

For example, the Genomic Data Sharing Policy applies to NIH-funded research generating large-scale human or non-human genomic data. If another applicable policy has more detailed expectations than what the DMS policy has, organizations should follow those expectations in addition to the DMS policy.

Research 52

Research Genome Genomics Genotype 52

XTalks

APRIL 29, 2021

However, the variant viral genomes will still persist in the latent reservoir as provirus and can be detected with proviral DNA testing. Importantly, ARV treatment does not affect the proviral DNA genome that persists in latently infected cells. Proviral DNA Genotyping. GenoSure Archive.

DNA 98

DNA Drugs RNA Genotype 98

pharmaphorum

NOVEMBER 10, 2021

It recommends the National Library of Medicine, which has already published “considerable information” on resistance genes, genome sequences, antimicrobial susceptibility data, and bacterial genomes, establish an open-source, unified AMR database.

Medicine 105

Medicine Genome Genomics Genotype 105

XTalks

FEBRUARY 4, 2021

The power of leveraging clinical data to decipher disease mechanisms and fuel drug discovery has rapidly grown in the era of genomics and personalized medicine. Genuity Science focuses on population genomics as a tool to derive novel biological insights through partnerships with industry-leading pharmaceutical and biotech companies.

Research 98

Research Biobanking Drugs Genome 98

XTalks

APRIL 24, 2023

These are, in my view, the most valid comparisons, particularly in inherited diseases where the genotype is obviously the same in each individual patient, and as a consequence, the difference in phenotype after gene therapy is a true difference,” he adds. What are the best ways to engage patients for long-term follow-up visits?

Gene Therapy 86

Gene Therapy Gene Trials Clinical Trials 86

The Pharma Data

SEPTEMBER 2, 2021

Durvalumab ± Tremelimumab + Platinum-Etoposide in 1L ES-SCLC: Exploratory Analysis of HLA Genotype and Survival in CASPIAN. A Phase 2 Study of Datopotamab Deruxtecan (Dato-DXd) in Advanced NSCLC With Actionable Genomic Alterations (TROPION-Lung05). Lead author. Abstract title. Presentation details. Immuno-Oncology. Garassino, MC.

Trials 52

Trials Medicine Antibody Clinical Trials 52

pharmaphorum

FEBRUARY 17, 2022

BEEHIVE’s researchers opted to use whole-genome sequencing (WGS) to evaluate the virus’ transformations over time. ” Researchers used whole-genome data, providing the 17 whole genomes available for the variant. About the author.

Genome 98

Genome Genomics Genetics Genotype 98