The Genomic Medicine Revolution: Multi-Modality Approaches in Advanced Therapies
Pharmaceutical Technology
AUGUST 16, 2024
Genomic medicines offer new techniques for treating conditions once thought to be intractable - a world of opportunity awaits.
Genome Genomics Medicine 
Hopewell Therapeutics raises funds for genomic medicines development
Pharmaceutical Technology
JUNE 8, 2023
Biotechnology company Hopewell Therapeutics has raised $25m in seed financing to accelerate the development of next-generation lipid nanoparticles for targeted delivery of genomic medicines. Hopewell Therapeutics is engaged in discovering, synthesising and developing advanced ttLNPs to provide next-generation genomic medicines.
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The future of genomic medicine: can it fulfil its promises?
pharmaphorum
SEPTEMBER 14, 2020
Here he gives us a deeper look at how genomic medicine is evolving and the barriers that are preventing it from reaching its full potential. I saw this, in particular, with the finishing of the human genome,” says Charlie. “At At that time, we thought this would be the holy grail for medicine.
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Working for a mature form of genomic medicines
pharmaphorum
MAY 29, 2024
In a new episode of the pharmaphorum podcast, Rahul Kakkar, CEO of gene editing company Tome, speaks with web editor Nicole Raleigh about programmable genomic integration (PGI) technology.
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Investment fuels AI-driven development of breakthrough genomic medicines
pharmaphorum
OCTOBER 12, 2022
David Del Bourgo (CEO and co-founder, Whitelab Genomics) has always been passionate about introducing disruptive, innovative technologies to markets. We founded Whitelab Genomics after realising the potential to use data, data science, and AI in a more systematic way to develop genomic therapies,” Del Bourgo says.
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From promise to reality: Unlocking the true business potential of genomic medicine
pharmaphorum
NOVEMBER 21, 2024
Explore how investing in genomic medicine can unlock the true business potential in the manufacturing and therapeutic areas. Understand the promise and reality of this cutting-edge field.
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New era of genomic medicine begins as UK approves Lilly’s Retsevmo
pharmaphorum
MARCH 12, 2021
The UK regulator has authorised Eli Lilly’s targeted cancer drug Retsevmo for tumours with RET fusion positive lung cancers and thyroid cancers, which the company said could herald a new era of genomic medicine for the NHS. billion collaboration with Bluebird Medicines to develop a rival RET inhibitor, pralsetinib.
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Mission Bio launches genome editing solution for Advanced Therapies
BioPharma Reporter
SEPTEMBER 12, 2023
Mission Bio, a leader in single-cell multi-omic solutions for precision medicine, has launched its new Tapestri Genome Editing Solution.
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How Will Ultima Genomics and Genome Insight Make WGS Affordable?
XTalks
APRIL 21, 2023
The application of whole genome sequencing (WGS) to derive a more complete understanding of cancer has been a central goal of cancer researchers even before the first human genome was decoded in 2003. Ultima Genomics has already partnered with other leading biotech startups.
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A new dawn of the genomic age: five areas set to be transformed in 2023
pharmaphorum
JANUARY 26, 2023
2022 was a banner year for genomics. In March, the collaborative T2T consortium published the first complete telomere-to-telomere sequence of the human genome, filling in the last 8% of the 3 billion base pairs that make up our DNA.
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AZ builds in genomic medicine with $1bn Pfizer deal
pharmaphorum
JULY 28, 2023
AZ builds in genomic medicine with $1bn Pfizer deal Phil.Taylor Fri, 28/07/2023 - 08:24 Bookmark this
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Genomic projects exploit scale as clinical applications play catch-up
Pharmaceutical Technology
JUNE 30, 2022
Analysing almost eight thousand tumours across 33 different cancers, researchers say this marks the first time that a framework was created to understand the role of internal factors in driving such genomic alterations. Genomic research have greatly expanded our understanding of disease pathophysiology over the years.
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Will 90 be the New 40? Genomics and Precision Medicine Equal Longer Health Span
BioSpace
JULY 14, 2022
Recent advances in precision medicine and genomics have launched an explosion in immunotherapies that are resulting in real cures and earlier diagnoses - and more healthy years for individuals.
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Verge Genomics takes AI-sourced drug for ALS into clinic
pharmaphorum
OCTOBER 31, 2022
Verge Genomics has joined a select group of biotechs who have taken a drug discovered and developed using artificial intelligence into human testing. Since then others have followed suit, including BenevolentAI with its BEN-2293 candidate for atopic dermatitis and Insilico Medicine with idiopathic pulmonary fibrosis therapy SM001-055.
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Micro-robots, smart toilets, and 3D bioprinted organs: the future of healthcare
Pharmaceutical Technology
SEPTEMBER 22, 2022
You have just received the results from your whole genome sequencing test, offered through your public health provider, and discovered that you have a 75% chance of developing a rare form of cancer. If a vaccine is not yet available, and the cancer has begun to grow, personalised medicine will be your best therapeutic solution.
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Genomic testing ‘should be offered to all cancer patients in Scotland’
pharmaphorum
NOVEMBER 27, 2022
A group representing pharma companies selling precision therapies for cancer has called for a change to the way genomic testing is done in Scotland, to make sure patients get access to targeted drugs. The post Genomic testing ‘should be offered to all cancer patients in Scotland’ appeared first on. Why not lead?”
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The use of genomic profiling testing to improve oncology care
pharmaphorum
SEPTEMBER 12, 2022
Alongside drugs and therapeutics, data collection and technology enhancements have redefined the traditional healthcare experience, especially within oncology, and genomic profiling has become a significant factor in allowing for personalised care. Tailored oncology. In other words, every person’s cancer has its own genetic construct.
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Here’s how the $100 Human Genome will Change Medicine
BioSpace
JULY 10, 2022
A silicon wafer offers the powerful insights of the human genome for the low price of $100. Ultima Genomics CEO Gilad Almogy discussed the therapeutic possibilities with BioSpace.
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Roche launches Foundation Medicine-partnered genomic profiling kit
Pharma Times
OCTOBER 25, 2021
Product designed to allow laboratories to expand in-house oncology research
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Large European study underlines power of genomic sequencing to diagnose diseases
STAT News
APRIL 12, 2023
LONDON — Using genome sequencing greatly expanded the number of diagnoses researchers could provide for children with developmental disorders from thousands of families across the United Kingdom and Ireland, researchers reported in a new study Wednesday. Read the rest…
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The pangenome is making personalised medicine more equitable
Pharmaceutical Technology
JUNE 14, 2023
All that DNA is organised into hereditary units called genes, with humans having about 25,000 genes collectively known as the genome. The Human Genome Project Launched in October 1990, The Human Genome Project sought to sequence the entire human genome using a method called Sanger sequencing.
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Elsevier partners with American College of Medical Genetics and Genomics to publish Genetics in Medicine
Scienmag
JULY 26, 2021
Collaboration signifies strong commitment by all stakeholders to maintain the journal’s high standards and expand its global prominence Credit: ACMG New York, July 26, 2021 – The American College of Medical Genetics and Genomics (ACMG), the only nationally recognized US medical professional organization solely dedicated to improving health (..)
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Deep Genomics is Rewriting RNA for Powerful Therapeutics with $180M Series C
BioSpace
JULY 27, 2021
"For the first time in history, medicine has become information." That's the groundbreaking connection AI-driven RNA therapeutics has given us, according to Deep Genomics Founder and CEO Brendan Frey.
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Rare Disease Diagnosis: Why Tackling the Genomic Analysis Bottleneck is Key to Advancing Precision Medicine
XTalks
NOVEMBER 10, 2020
For more information on tackling this “genomic analysis bottleneck,” watch this on-demand webinar. HS: Due to the heterogeneity of the rare disease population, there are many relevant gene lists, and the genomic data analysis of these patients covers almost 2,000 different genetic targets.
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DoH, M42 and AbbVie partner for personalised medicines in Abu Dhabi
Pharmaceutical Technology
JUNE 20, 2023
The Department of Health Abu Dhabi (DoH) has signed a memorandum of understanding with integrated healthcare company M42 and AbbVie Biopharmaceuticals to advance personalised medicine and genomics in the city. M42 was created through the combination of Mubadala Health and G42 Healthcare.
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Experts call for using pharmacogenetics to develop treatments for rare diseases
AuroBlog - Aurous Healthcare Clinical Trials blog
NOVEMBER 1, 2022
As drug companies have embarked on an initiative to launch affordable medicines for rare diseases in India, experts have called for using pharmacogenetics to develop treatments and whole genome sequencing to identify etiologies.
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Startup focused on genomics data joins national health care accelerator
Scienmag
SEPTEMBER 22, 2020
– A Purdue Foundry-affiliated company with a growing reputation as a search engine for genome sequence data in life sciences has joined a nationally ranked health care startup accelerator. Credit: Karyosoft/Rajesh Perianayagam WEST LAFAYETTE, Ind.
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Green tea compound aids p53, ‘guardian of the genome’ and tumor suppressor
Scienmag
FEBRUARY 12, 2021
— An antioxidant found in green tea may increase levels of p53, a natural anti-cancer protein, known as the “guardian of the genome” for its ability to repair DNA damage or destroy cancerous cells. Research offers new lead for cancer drug discovery Credit: Rensselaer Polytechnic Institute TROY, N.Y.
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Salk Assistant Professor Graham McVicker receives Genomic Innovator Award
Scienmag
SEPTEMBER 30, 2021
LA JOLLA—(September 30, 2021) Salk Assistant Professor Graham McVicker has been awarded a National Human Genome Research Institute (NHGRI) Genomic Innovator Award, which supports early-career scientists who conduct innovative, creative research in genomics. The award, which provides $2.85
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AI and genomic surveillance combine to detect health care infectious disease outbreaks
Scienmag
NOVEMBER 16, 2021
17, 2021 – By coupling machine learning with whole genome sequencing, University of Pittsburgh School of Medicine and Carnegie Mellon University scientists greatly improved the quick detection of infectious disease outbreaks within a hospital setting over traditional methods for tracking outbreaks. PITTSBURGH, Nov.
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F. Hoffmann-La Roche gets grant for system for identifying nucleic acid bases using nanopore technology
Pharmaceutical Technology
APRIL 4, 2024
Explore the innovative approach in genomics and personalized medicine. Hoffmann-La Roche's patented system uses nanopores to identify nucleic acid bases, increasing confidence in base identification.
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Nobel Prize in medicine awarded for research into the evolutionary history of humankind
STAT News
OCTOBER 3, 2022
A Swedish scientist won the 2022 Nobel Prize in medicine or physiology on Monday for his groundbreaking research into the evolutionary history of humankind. Pääbo unlocked scientists’ understanding of how genes from these extinct relatives have been passed down to present-day humans.
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BMS’s repotrectinib to have FoundationOne genomic sequencing companion diagnostic
Pharmaceutical Technology
APRIL 12, 2023
Foundation Medicine has announced it will supply a tissue-based test as a companion diagnostic for Bristol Myers Squibb’s (BMS) recently acquired ROS1/TRK inhibitor repotrectinib. FoundationOne CDx is a sequencing-based in vitro diagnostic device that can identify alterations in 324 genes from tumour samples.
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Hayes honored for contributions to groundbreaking cancer genomic research
Scienmag
AUGUST 7, 2020
Credit: UTHSC Neil Hayes, MD, MS, MPH, division chief of Hematology and Oncology at the University of Tennessee Health Science Center, is among recipients of the 2020 Team Science Awards from the American Association for Cancer Research (AACR) for his contributions to developing The Cancer Genome Atlas (TCGA), a groundbreaking multisite project to (..)
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Genentech and Sangamo to develop neurodegenerative disease therapies
Pharmaceutical Technology
AUGUST 7, 2024
Sangamo Therapeutics has signed an agreement with Genentech for the development of genomic medicines to treat neurodegenerative diseases.
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Genomic analysis reveals many animal species may be vulnerable to SARS-CoV-2 infection
Scienmag
AUGUST 21, 2020
An international team of scientists used genomic analysis to compare the main cellular receptor for the virus in humans — angiotensin converting […].
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GSK partners LifeMine on fungi-derived medicines
pharmaphorum
MARCH 24, 2022
There’s a rich history of finding useful medicines from fungi, from the antibiotic penicillin to immune suppressant cyclosporine and cholesterol drug lovastatin. The post GSK partners LifeMine on fungi-derived medicines appeared first on. Image by jggrz from Pixabay .
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Oncotarget: Genome wide DNA methylation landscape reveals glioblastoma’s influence
Scienmag
JULY 4, 2021
These Oncotarget results suggest that GBM might induce epigenetic alterations in tumor infiltrating CD4 T-cells Credit: Correspondence to – Mahua Dey – dey@neurosurgery.wisc.edu Oncotarget published “Genome wide DNA methylation landscape reveals glioblastoma’s influence on epigenetic changes in tumor infiltrating CD4+ T cells” (..)
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Abu Dhabi DoH signs new deal to accelerate development in life sciences
Pharmaceutical Technology
JUNE 16, 2023
Benefiting from Abu Dhabi’s improved genomics capabilities, the deal seeks to expand research into genomic medicine and genetic diseases to provide patients in the UAE and beyond with improved access to new tools and treatments.
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Blacksmith Medicines to merge with Forge Therapeutics
Pharmaceutical Technology
JANUARY 3, 2023
Blacksmith Medicines has signed a definitive merger agreement with Forge Therapeutics to create a combined entity that will discover and develop medicines targeting a large class of proteins called metalloenzymes. The merged entity will focus on developing medicines with an initial focus on oncology and infection.
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Ethnic diversity helps identify more genomic regions linked to diabetes-related traits
Scienmag
MAY 31, 2021
By including multi-ethnic participants, a largescale genetic study has identified more regions of the genome linked to type 2 diabetes-related traits than if the research had been conducted in Europeans alone.
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The state of oligonucleotide therapeutic manufacturing: what biopharmaceutical players need to know
Pharmaceutical Technology
MARCH 11, 2024
In the genomic medicine toolbox, oligonucleotide therapeutics offer highly specific and effective treatments
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New research shows whole genome sequencing provides extensive insights into Hodgkin lymphoma
Medical Xpress
FEBRUARY 21, 2023
A large research project, led by scientists at Sylvester Comprehensive Cancer Center in the University of Miami Miller School of Medicine, Memorial Sloan Kettering Cancer Center, and Weill Cornell Medical College, has found that whole genome sequencing (WGS) can provide much more information about classic Hodgkin lymphoma (cHL) than exome sequencing, (..)
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