Scientists expand entomological research using genome editing
Scienmag
JULY 22, 2022
Genome sequencing, where scientists use laboratory methods to determine a specific organism’s genetic makeup, is becoming a common practice in insect research.
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Modernizing cell culture processes for the next wave of genomic medicine
Pharmaceutical Technology
FEBRUARY 3, 2023
The field of genomic medicine has reached a true turning point. With scientists fervently developing mRNA vaccines, nucleic acid therapeutics, and viral vector-based gene therapies, clinicians are set to have a growing number of tools available to treat a wide range of conditions, from infectious diseases to genetic disorders and more.
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A new dawn of the genomic age: five areas set to be transformed in 2023
pharmaphorum
JANUARY 26, 2023
2022 was a banner year for genomics. In March, the collaborative T2T consortium published the first complete telomere-to-telomere sequence of the human genome, filling in the last 8% of the 3 billion base pairs that make up our DNA.
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Inclusive new tool makes genomic research better reflect world’s diversity
Scienmag
MARCH 10, 2022
Scientists have developed a powerful, inclusive new tool for genomic research that boosts efforts to develop more precise treatments for many diseases by leveraging a better representation of the genetic diversity of people around the world.
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Magazine: Genomic projects exploit scale as clinical applications play catch-up
Pharmaceutical Technology
JULY 26, 2022
The last few months have marked the publication of research emerging from projects designed to collect and analyse genomic data on a wider scale than was previously thought possible. The post Magazine: Genomic projects exploit scale as clinical applications play catch-up appeared first on Pharmaceutical Technology.
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Genomic projects exploit scale as clinical applications play catch-up
Pharmaceutical Technology
JUNE 30, 2022
Earlier this month, scientists from Cambridge University and the Madrid-based National Cancer Research Center described a novel framework tracking chromosomal instability and copy number changes in particularly deadly cancers. Genomic research have greatly expanded our understanding of disease pathophysiology over the years.
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How Will Ultima Genomics and Genome Insight Make WGS Affordable?
XTalks
APRIL 21, 2023
The application of whole genome sequencing (WGS) to derive a more complete understanding of cancer has been a central goal of cancer researchers even before the first human genome was decoded in 2003. Ultima Genomics has already partnered with other leading biotech startups.
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The future of genomic medicine: can it fulfil its promises?
pharmaphorum
SEPTEMBER 14, 2020
Here he gives us a deeper look at how genomic medicine is evolving and the barriers that are preventing it from reaching its full potential. I saw this, in particular, with the finishing of the human genome,” says Charlie. “At In reality, finishing the human genome was the first step of what is a long journey.”.
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Nobel Prize in medicine awarded for research into the evolutionary history of humankind
STAT News
OCTOBER 3, 2022
A Swedish scientist won the 2022 Nobel Prize in medicine or physiology on Monday for his groundbreaking research into the evolutionary history of humankind. Pääbo unlocked scientists’ understanding of how genes from these extinct relatives have been passed down to present-day humans. Read the rest…
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STAT+: Ahead of genome summit in London, questions linger about CRISPR baby scandal
STAT News
MARCH 3, 2023
Next week, hundreds of scientists from around the world will convene in London for an international summit on genome editing. That technology, which enables scientists to easily excise, alter, or replace specific sections of DNA, was awarded the 2020 Nobel Prize for Chemistry. Continue to STAT+ to read the full story…
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Stanford scientist who broke genome sequencing record on what faster diagnoses mean for patients
STAT News
MARCH 22, 2023
Stanford cardiologist Euan Ashley and his research team received a Guinness World Record last year for sequencing a full human genome in just over five hours. Ashley is at the forefront of a push by researchers to make more genetic information available to patients facing major health care decisions.
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USDA-ARS releases genome of the voracious desert locust
Scienmag
JUNE 26, 2022
June 27, 2022–The first high-quality genome of the desert locust—those voracious feeders of plague and devastation infamy and the most destructive migratory insect in the world—has been produced by U.S. Department of Agriculture Agricultural Research Service scientists. Credit: Photo by Brandon Woo.
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STAT+: At genome-editing summit, experts worry that rule changes on embryo research in China fall short
STAT News
MARCH 6, 2023
That was the message Chinese scientists delivered Monday on the opening day of the Third International Summit on Human Genome Editing in London. LONDON — The first gene-edited children were born in China five years ago , but it’s unlikely to happen again there anytime soon.
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STAT+: Moderna expands CRISPR gene editing research with ElevateBio partnership
STAT News
FEBRUARY 22, 2023
Moderna will fund preclinical research studies run by the two companies using Life Edit’s tools based on CRISPR technologies that allow scientists to make precise changes to the human genome. Life Edit is the North Carolina subsidiary of ElevateBio, a cell and gene therapy manufacturing firm in Waltham.
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Genome Atlas to support the rescue of biodiversity in Europe
Scienmag
JANUARY 26, 2022
To provide important genomic data to inform research about Europe’s biodiversity, scientists from 48 different countries initiated the “European Reference Genome Atlas” (ERGA) in 2021.
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UK scientists say they have found cancer driver in junk DNA
pharmaphorum
JULY 20, 2022
Now, scientists in the UK think they have found a culprit implicated in cancer. Just how that happens hasn’t been discovered, but scientists from the Institute of Cancer Research (ICR) in the UK think they have now identified a potential mechanism. billion last year.
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Salk Assistant Professor Graham McVicker receives Genomic Innovator Award
Scienmag
SEPTEMBER 30, 2021
LA JOLLA—(September 30, 2021) Salk Assistant Professor Graham McVicker has been awarded a National Human Genome Research Institute (NHGRI) Genomic Innovator Award, which supports early-career scientists who conduct innovative, creative research in genomics. The award, which provides $2.85
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Clinical Scientist Jobs: The Steps to Succeed in This Role
XTalks
MAY 20, 2022
Do you possess laboratory skills, an analytical mindset and a penchant for research? If you enjoy working with biological samples and are enthusiastic about healthcare, a career as a clinical scientist might be just right for you. To start applying to clinical scientist jobs today, head over to the Xtalks Job Search platform.
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New research shows whole genome sequencing provides extensive insights into Hodgkin lymphoma
Medical Xpress
FEBRUARY 21, 2023
A large research project, led by scientists at Sylvester Comprehensive Cancer Center in the University of Miami Miller School of Medicine, Memorial Sloan Kettering Cancer Center, and Weill Cornell Medical College, has found that whole genome sequencing (WGS) can provide much more information about classic Hodgkin lymphoma (cHL) than exome sequencing, (..)
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Researchers unlock pattern of gene activity for ADHD
Medical Xpress
NOVEMBER 16, 2022
Researchers at the National Institutes of Health have successfully identified differences in gene activity in the brains of people with attention deficit hyperactivity disorder (ADHD).
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Affordable genome sequencing for pathogen analysis to help tackle global epidemics
Scienmag
DECEMBER 20, 2021
A worldwide consortium of scientists, led by the Earlham Institute and the University of Liverpool in the UK, mark a significant milestone in equipping researchers in low- and middle-income countries (LMICs) with cheap and accessible methods for sequencing large collections of bacterial pathogens – at a cost of less than $10USD per genome.
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Researchers identify large genetic changes that contribute to dementia risk
Medical Xpress
MAY 8, 2023
Scientists at the National Institutes of Health have identified new genetic risk factors for two types of non-Alzheimer's dementia. These findings were published in Cell Genomics and detail how researchers identified large-scale DNA changes, known as structural variants, by analyzing thousands of DNA samples.
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Scientists discover innate tumor suppression mechanism
Medical Xpress
MAY 4, 2023
The p53 gene is one of the most important in the human genome: the only role of the p53 protein that this gene encodes is to sense when a tumor is forming and to kill it. While the gene was discovered more than four decades ago, researchers have so far been unsuccessful at determining exactly how it works.
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Scientists discover a rare neurological disease involving cellular recycling
Medical Xpress
FEBRUARY 10, 2023
Researchers at the National Institutes of Health have discovered a new neurological condition characterized by issues with motor coordination and speech. They report their findings in npj Genomic Medicine.
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Japanese-European research team discovers novel genetic mitochondrial disorder
Scienmag
APRIL 15, 2021
Team of Japanese and European scientists identify a novel genetic mitochondrial disorder by analyzing DNA samples from three distinct families Credit: Fujita Health University DNA ligase proteins, which facilitate the formation of bonds between separate strands of DNA, play critical roles in the replication and maintenance of DNA.
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Researchers pioneer new method to edit genes in human cells
Scienmag
JANUARY 5, 2022
SAN FRANCISCO, CA—January 5, 2021—Over the past decade, the CRISPR genome-editing system has revolutionized molecular biology, giving scientists the ability to alter genes inside living cells for research or medical applications.
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Why early participant engagement is now a top priority in genetic disease research
pharmaphorum
JANUARY 18, 2023
In 2016, scientists behind a study called the Resilience Project analysed genetic data from 589,000+ people and found 13 adults who carried genetic variants that should have resulted in serious – even deadly – childhood disease, but who were apparently healthy. Giving participants something in return. with their priorities.
The pangenome is making personalised medicine more equitable
Pharmaceutical Technology
JUNE 14, 2023
All that DNA is organised into hereditary units called genes, with humans having about 25,000 genes collectively known as the genome. The Human Genome Project Launched in October 1990, The Human Genome Project sought to sequence the entire human genome using a method called Sanger sequencing.
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Leveraging Genetic Testing for Enrolling Rare Disease Trials
Worldwide Clinical Trials
JANUARY 24, 2024
However, clinical research around Fragile X is considerably robust, making the possibility of clinical trial participation a potential motivation for parents to choose to undergo genetic testing for their children. Further, the need for their education will drastically increase if Newborn Sequencing continues to grow.
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UK-wide whole genome sequencing for newborns is feasible – but there are some key questions to answer first
pharmaphorum
NOVEMBER 23, 2021
Genomics England, the Department of Health and Social Care’s genome-sequencing hub, has this year announced that support for whole genome sequencing (WGS) has reached a level at which its national rollout on the NHS may someday become a reality. Only when genomic databases are diverse can we ensure that we all benefit equally.
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Capuchin monkey genome reveals clues to its long life and large brain
Scienmag
FEBRUARY 14, 2021
An international team of scientists has sequenced the genome of a capuchin monkey for the first time, uncovering new genetic clues about the evolution of their long lifespan and large brains. Published in PNAS, the work was led by the University of Calgary in Canada and involved researchers at the University of Liverpool.
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New ways of looking at effective cancer treatment
Drug Discovery World podcast
DECEMBER 12, 2024
They are called: 3D Genomics and targeted cancer therapies , Democratising proteomics for cancer and beyond, and Meet the Researcher: John Maher In the first article, Anthony Schmitt, PhD, Senior Vice President, Science at Arima Genomics, discusses the applications of 3D genomics in cancer research.
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Researchers identify hallmarks to improving pancreatic cancer therapy
Medical Xpress
APRIL 13, 2023
Scientists from the University of California, Irvine, the University of Michigan and the University of Texas MD Anderson Cancer Center have made a significant contribution to the field of pancreatic cancer research. The study appears in the journal Cell.
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Singapore scientists develop novel gene editor to correct disease-causing mutations
Scienmag
MARCH 11, 2021
The CRISPR-based gene editor, C-to-G Base Editor (CGBE), opens up treatment avenues for up to 40 per cent of genetic disorders caused by single-nucleotide mutations Credit: Agency for Science, Technology and Research (A*STAR), Genome Institute of Singapore (GIS) A team of researchers from the Agency for Science, Technology and Research’s (A*STAR) (..)
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#news #biotech Scientists advance understanding of hop genome, which could aid brewers, medical researchers
BioTech 365
FEBRUARY 22, 2021
Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Scientists advance understanding of hop genome, which could aid brewers, medical researchers.Oregon State University and U.S.
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Babraham Institute makes breakthrough in early human embryo research
pharmaphorum
FEBRUARY 25, 2022
A new stem cell model, discovered by researchers exploring the human genome, will help scientists to map out the key genomic changes during early development. Prior to this latest development, research into the human ZGA was limited to human embryos at a later stage of growth, under stringent UK regulations.
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#news #biotech Scientists update genome editing technology
BioTech 365
SEPTEMBER 16, 2020
Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Scientists update genome editing technology.Researchers from Peter the Great St.
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New improved dog reference genome will aid a new generation of investigation
Scienmag
FEBRUARY 10, 2021
Researchers at Uppsala University and the Swedish University of Agricultural Sciences have used new methods for DNA sequencing and annotation to build a new, and more complete, dog reference genome.
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Nucleome raises £37.5m to shine light on ‘dark genome’
pharmaphorum
OCTOBER 19, 2022
million ($40 million) first-round financing that will be used to explore so-called ‘dark’ regions of the human genome. Nucleome’s platform adds 3D genomic information to a wealth of available genomic data, uncovering a new dimension of information that is disease as well as cell type-specific.
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Study provides evidence of protective link between oral microbiome and COVID
Medical Xpress
NOVEMBER 11, 2022
Using high-throughput genome sequencing and machine learning, scientists at UMass Chan Medical School have shown a strong correlation between the oral microbiome in patients with COVID-19 at the time of hospital admission and the need for later respiratory support.
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Scribe and Sanofi partner to develop cell therapies for cancer
Pharmaceutical Technology
SEPTEMBER 29, 2022
The alliance will leverage the CRISPR genome editing technologies of Scribe to facilitate in genetic modification of new natural killer (NK) cell therapeutics for cancer. According to the deal, Sanofi will make an upfront payment of $25m to Scribe. Cell & Gene Therapy coverage on Pharmaceutical Technology is supported by Cytiva.
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International Cancer Genome Consortium empowers cancer researchers everywhere with new cloud computing platform
The Pharma Data
NOVEMBER 25, 2021
The International Cancer Genome Consortium (ICGC) is further enabling cancer research worldwide by making a massive collection of cancer data available for analysis via Microsoft’s Azure cloud computing platform. ” ICGC has now moved into its next phase called ICGC ARGO (Accelerating Research in Genomic Oncology). .”
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Roche launches comprehensive genomic profiling kit to expand access to personalised cancer research
The Pharma Data
OCTOBER 26, 2021
The AVENIO Tumor Tissue Comprehensive Genomic Profiling (CGP) Kit is the first jointly-developed product that brings together the expertise and reach of Roche with Foundation Medicine’s pioneering leadership in genomic science. Cancer is a disease of the genome and treatment no longer depends solely on the tissue of origin.
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New wheat and barley genomes will help feed the world
Scienmag
NOVEMBER 25, 2020
Credit: University of Adelaide An international research collaboration, including scientists from the University of Adelaide’s Waite Research Institute, has unlocked new genetic variation in wheat and barley – a major boost for the global effort in breeding higher-yielding wheat and barley varieties.
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