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Aardvark Therapeutics IPO Sets Sights on Satiating Hyperphagia and Extreme Hunger

XTalks

In the gut, these receptors prompt the release of hormones such as cholecystokinin and GLP-1, which together signal satiety. This approach aims to combine TAS2R activation with enhanced incretin hormone modulation, potentially offering a more robust treatment for obesity and related conditions.

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Genomic assay may predict long-term prognosis in premenopausal patients with HR-positive early-stage breast cancer

Medical Xpress

Among premenopausal women with hormone receptor (HR)-positive, early-stage breast cancer enrolled in the SOFT trial, those with a high score on a genomic assay called Breast Cancer Index (BCI) had increased risk of distant recurrence, and those with low BCI benefited more from the addition of ovarian suppression therapy to endocrine therapy after 12 (..)

HR 54
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International Women’s Day 2024: A Spotlight on 5 Women’s Health Webinars with Xtalks

XTalks

Optimizing Sleep During Perimenopause and Beyond Sleep plays a crucial role in overall health, particularly for midlife women transitioning into menopause, a phase marked by perimenopause where hormonal changes can severely disrupt sleep due to symptoms like nocturnal hot flashes.

Genetics 115
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In a gene tied to growth, scientists see glimmers of human history

Scienmag

. — A new study delves into the evolution and function of the human growth hormone receptor gene, and asks what forces in humanity’s past may have driven changes to this vital piece of DNA. Genome assembly diagrams generated by the Integrative Genomics […].

Gene 52
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NICE backs two new breast cancer drugs for NHS use

pharmaphorum

Piqray (alpelisib) meanwhile is a once-daily, oral PI3K inhibitor that has been cleared for use in combination with hormonal therapy (fulvestrant) for hormone receptor-positive, HER2-negative, PIK3CA-mutated locally advanced or metastatic breast cancer, that has progressed after endocrine and CDK4/6 inhibitor therapy.

Drugs 104
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The FDA’s Guidance on Gene Edited Foods + What American Foods are Banned in Other Countries? – Xtalks Food Podcast Ep. 149

XTalks

In a pivotal move for the food industry, the US Food and Drug Administration (FDA) has unveiled industry guidance for genome edited foods derived from plants. Genome editing stands as a cutting-edge technique that ingeniously introduces new traits into plants.

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Roche to present data from industry leading portfolio at ESMO.

The Pharma Data

Genomic data from the phase II CUPISCO study in Cancer of Unknown Primary (CUP), an uncommon type of cancer with high unmet need, could support diagnostics and more personalised treatment plans. Comprehensive genomic profiling. Comprehensive genomic profiling. Comprehensive genomic profiling. Real world data.