pharmaphorum

SEPTEMBER 12, 2022

Alongside drugs and therapeutics, data collection and technology enhancements have redefined the traditional healthcare experience, especially within oncology, and genomic profiling has become a significant factor in allowing for personalised care. Tailored oncology.

Genomics 105

Genomics Genome Clinical Trials Clinical Trials 105

Scienmag

MARCH 12, 2021

Credit: The Wistar Institute PHILADELPHIA — (March 12, 2021) — Scientists at The Wistar Institute identified a new function of ADAR1, a protein responsible for RNA editing, discovering that the ADAR1p110 isoform regulates genome […].

RNA 92

RNA Protein Genomics Genome 92

World of DTC Marketing

DECEMBER 29, 2020

Both the Pfizer and Moderna vaccines copied RNA sequence from the virus genome and found a way to manufacture it at scale with high-level processes and quality control. First, a novel approach was used that didn’t require traditional vaccine production in cell cultures or eggs. 1455NO-HEALTH-CORONAVIRUS_VACCINES_PFIZER_O_.

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Vaccine Vaccination Development Clinical Trials 307

Scienmag

JUNE 13, 2022

For many years, the human genome was viewed as a book of life in which sections of great eloquence and economy of expression were interspersed with vast stretches of gibberish.

Genomics 77

Genomics Genome DNA Containment 77

Scienmag

OCTOBER 21, 2020

Comprised of only 29 proteins (compared to our 400,000), with a genome 1/200,000 the size of ours, […].

Protein 76

Protein Genomics Genome Research 76

Scienmag

JUNE 28, 2021

Small molecule designed to inhibit protein aggregation associated with Alzheimer’s disease and Type II diabetes is shown to effectively reactivate a critical tumor suppressor protein inactivated in more than one-half of all human cancers Fast facts 1) Dubbed the ‘guardian of the genome’, p53 is a tumor suppressor protein that prevents (..)

Protein 72

Protein Genomics Genome Development 72

Medical Xpress

FEBRUARY 21, 2023

A large research project, led by scientists at Sylvester Comprehensive Cancer Center in the University of Miami Miller School of Medicine, Memorial Sloan Kettering Cancer Center, and Weill Cornell Medical College, has found that whole genome sequencing (WGS) can provide much more information about classic Hodgkin lymphoma (cHL) than exome sequencing, (..)

Genomics 75

Genomics Genome Research Protein 75

Pharmaceutical Technology

FEBRUARY 13, 2023

With the latest advances in whole genome sequencing , it is increasingly clear that rare epilepsies are largely caused by a single genomic mutation, says Ferraro. Rather than replacing mutated genes with functional copies, STK-001 promotes protein production in the healthy copy of the SCN1a gene.

Research 264

Research Gene Gene Therapy Genome 264

Scienmag

NOVEMBER 20, 2021

Professor Norikazu Ichihashi and his colleagues at the University of Tokyo have successfully induced gene expression from a DNA, characteristic of all life, and evolution through continuous replication extracellularly using cell-free materials alone, such as nucleic acids and proteins for the first time.

DNA 96

DNA Gene Expression Genomics Genome 96

Scienmag

DECEMBER 22, 2021

Genes code for proteins – the building blocks of life. of our entire DNA Very little is known about the function of regions of DNA outside our genes – termed the ‘dark genome’ A Cambridge-led team recently discovered that proteins are produced by over […].

Genomics 63

Genomics Genome DNA Gene 63

Medical Xpress

MAY 4, 2023

A major challenge in human genetics is understanding which parts of the genome drive specific traits or contribute to disease risk. This challenge is even greater for genetic variants found in the 98% of the genome that does not encode proteins.

Genetics 98

Genetics Genomics Genome Protein 98

BioPharma Reporter

OCTOBER 2, 2023

X-Chem, a company focused on drug discovery services, and the Structural Genomics Consortium (SGC), a public-private partnership accelerating drug discovery through open science, have partnered to create new chemical tools to study human proteins.

Genomics 64

Genomics Genome Protein Drugs 64

Medical Xpress

APRIL 17, 2023

Columbia researchers have shined new light on how the "dark" part of the genome allows cancer cells to be detected by the immune system, which could lead to better immunotherapies.

Protein 75

Protein Genomics Genome Research 75

pharmaphorum

JULY 26, 2021

The most complete database of protein structures ever assembled, developed with the help of Google’s artificial intelligence unit DeepMind, has been made freely available to researchers around the world. Demis Hassabis. ” The post Google’s DeepMind puts human proteome online for free appeared first on.

Protein 130

Protein Genome Genomics Life Science 130

Pharmaceutical Technology

JUNE 23, 2022

It functions as a molecular scissor by slicing long chains of virus’ polypeptide proteins into smaller component proteins. These viruses can develop rapid defences at the cellular level by orchestrating these layers, or folding mechanisms, in viral proteins so the key is to find a way to shut them down.”.

Drugs 130

Drugs Protein Genome Genomics 130

Scienmag

APRIL 15, 2021

Epigenetic regulator HPI1a drives de novo genome reorganization in early Drosophila embryos Credit: MPI of Immunobiology and Epigenetics, F. Instead, it is folded in a very organized way by the help of different proteins to establish a unique spatial organization of the genetic information. This […].

Genomics 56

Genomics Genome DNA Genetics 56

Pharmaceutical Technology

JUNE 4, 2023

AAV genomes are highly compact, with overlapping coding regions, alternate splicing schemes, and multiple transcription initiation codons. There are two main genes in the AAV genome, rep and cap, which encode nine different proteins. Transcription of the cap gene is initiated from a single promoter termed p40.

Gene 262

Gene Gene Therapy Genetics DNA 262

Drug Discovery World podcast

DECEMBER 12, 2024

They are called: 3D Genomics and targeted cancer therapies , Democratising proteomics for cancer and beyond, and Meet the Researcher: John Maher In the first article, Anthony Schmitt, PhD, Senior Vice President, Science at Arima Genomics, discusses the applications of 3D genomics in cancer research.

Genomics 52

Genomics Genome Protein Scientist 52

Scienmag

APRIL 15, 2021

Team of Japanese and European scientists identify a novel genetic mitochondrial disorder by analyzing DNA samples from three distinct families Credit: Fujita Health University DNA ligase proteins, which facilitate the formation of bonds between separate strands of DNA, play critical roles in the replication and maintenance of DNA.

Genetics 105

Genetics DNA Genomics Genome 105

Scienmag

MARCH 9, 2022

— Each simple RNA virus has a genome, its “native RNA.” This genome dictates how the virus replicates in cells to eventually cause disease. The genome also has the code for making a capsid, the protein shell of a virus that encapsulates the genome and protects it like a nanocontainer. RIVERSIDE, Calif.

Packaging 84

Packaging Packaging Genetics Genomics 84

Roots Analysis

FEBRUARY 15, 2022

Gene engineering based on recombination was pioneered in the mid-1990s; Currently, development of gene editing technologies has opened up the possibility of modifying genomic sequences in both eukaryotic and prokaryotic organisms. Genome Editing is a way of making changes in the DNA. Type of Genome Editing: Zinc-Finger Nuclease.

Genomics 52

Genomics Genome Gene Editing DNA 52

Pharmaceutical Technology

FEBRUARY 15, 2023

Innovation S-curve for the pharmaceutical industry CRISPR nuclease is a key innovation area in pharmaceutical development CRISPR, which refers to clustered regularly interspaced short palindromic repeats, are bacteriophage-derived DNA sequences that had previously infected the prokaryote and are found in the genomes of bacteria and archaea.

In-Vivo 162

In-Vivo Genome Genomics Gene Editing 162

Medical Xpress

MAY 4, 2023

The p53 gene is one of the most important in the human genome: the only role of the p53 protein that this gene encodes is to sense when a tumor is forming and to kill it. While the gene was discovered more than four decades ago, researchers have so far been unsuccessful at determining exactly how it works.

Scientist 104

Scientist Gene Genome Genomics 104

pharmaphorum

AUGUST 4, 2022

Unlocking the secrets of the human genome has long been an ambitious pursuit for researchers around the world. Today, the landscape of genomic testing and research is rapidly progressing, with significant scientific and technological advances driving a paradigm shift in the understanding of oncology at a molecular level.

Genomics 52

Genomics Genome Genome Project DNA 52

The Pharma Data

MARCH 7, 2022

By combining CRISPR technology with a protein designed with artificial intelligence (AI), it is possible to awaken individual dormant genes by disabling the chemical “off switches” that silence them. PRC2 can be blocked with chemicals, but they are imprecise, affecting PRC2 function throughout the genome. it can be reawakened.

Protein 52

Protein Gene Genome Genomics 52

pharmaphorum

JANUARY 29, 2021

Genome editing is an exciting but still nascent field, and companies in the area face as many obstacles as they do opportunities. ZFPs can be engineered to make zinc finger nucleases, or ZFNs, which are proteins that can be used to edit genomes by knocking select genes in or out to specifically modify DNA sequences.

Gene Editing 145

Gene Editing Gene Gene Therapy In-Vivo 145

Roots Analysis

AUGUST 28, 2022

Recent advances in multi-omics approaches, including genomics, transcriptomics, proteomics, metabolomics, cytometry and imaging, in combination with bioinformatics and biostatistics, have been translated into several popular bioanalytical platforms, such as next-generation sequencing (NGS), single-cell analysis, flow cytometry and mass spectrometry.

Genomics 52

Genomics Genome RNA Genome Project 52

Scienmag

NOVEMBER 20, 2020

20, 2020) — For more than a decade, scientists studying epigenetics have used a powerful method called ChIP-seq to map changes in proteins and other critical regulatory factors across the genome. Credit: Courtesy of Van Andel Institute GRAND RAPIDS, Mich.

Genomics 91

Genomics Genome Protein Scientist 91

Roots Analysis

SEPTEMBER 9, 2024

Over the years, pharmaceutical companies have shifted their priorities from traditional interventions towards more advanced pharmacological strategies, such as protein therapeutics. Further, $400 billion is the anticipated sales of protein-based therapeutics in 2023. The mRNA is then translated into to form functional proteins.

Protein 40

Protein Gene Production DNA 40

Scienmag

NOVEMBER 20, 2020

It contains the information for the production of 27 proteins. This is not much compared to the possible 40,000 kinds of protein that a […].

Genomics 70

Genomics Genome RNA Protein 70

Scienmag

OCTOBER 13, 2020

The key is a double occupation by two methyl groups on the DNA packaging protein histone H3 (H3K4me2). A research team from Cologne has discovered that a change in the DNA structure – more precisely in the chromatin – plays a decisive role in the recovery phase after DNA damage. The discovery was made by […].

DNA 72

DNA Genomics Genome Research 72

BioTech 365

JUNE 4, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: The cut and restore protein trick: Self-excising designer proteins.Our proteome is much bigger than our genome because one gene produces several variants of proteins called protein isoforms, … Continue reading →

Protein 40

Protein Genomics Genome Gene 40

Pharmaceutical Technology

JULY 5, 2022

Researchers at the UNC School of Medicine have discovered that hepatitis A virus (HAV) replication needs particular interactions between the human protein ZCCHC14 and TENT4 poly(A) polymerases, a group of enzymes. HAV usually hijacks TENT4 and utilises it for the replication of its own genome.

Protein 130

Protein RNA Genome Genomics 130

pharmaphorum

MAY 12, 2022

Bristol-Myers Squibb’s Celgene unit has clearly been impressed by progress in its four-year-old alliance with Evotec on protein degradation. These small drug compounds destabilise proteins by bringing them into proximity with enzymes called E3 ubiquitin ligases that cause them to be broken down. billion partnership last week. .

Protein 52

Protein Genome Genomics Drugs 52

The Pharma Data

MARCH 15, 2022

The p53 protein protects our cells from cancer and is an interesting target for cancer treatments. Researchers at Karolinska Institutet in Sweden have now found an unusual way of stabilising the protein and making it more potent. The new protein also proved to be more stable than ordinary p53 and capable of killing cancer cells.

Protein 52

Protein Research Genetics DNA 52

The Pharma Data

MARCH 23, 2022

Polymerase is a viral protein that directs how Ebola virus replicates its genome as it infects new hosts. The researchers discovered that Ebola virus polymerase hijacks a cellular protein called GSPT1. To treat Ebola virus infections, researchers are taking a close look at a key piece of the virus: polymerase.

Protein 52

Protein Genome Genomics Research 52

Bioengineer

JANUARY 16, 2024

This mutation hinders the drug’s binding to the mutant EGFR protein. Osimertinib, however, can covalently bind to the T790M and cysteine-797 (C797) residue at the protein’s ATP binding site, overcoming resistance mechanisms. T790M loss has been linked to earlier resistance and poorer survival in other cohorts.

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Genome Genomics Protein In-Vitro 119