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Tome acquires startup Replace, gaining new genome editing tools

Bio Pharma Dive

The deal is the second startup sale engineered by University of California, Berkeley scientist Shakked Halperin, and gives Tome a way to insert or delete small DNA sequences into the genome.

Genomics 176
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UK-wide whole genome sequencing for newborns is feasible – but there are some key questions to answer first

pharmaphorum

Genomics England, the Department of Health and Social Care’s genome-sequencing hub, has this year announced that support for whole genome sequencing (WGS) has reached a level at which its national rollout on the NHS may someday become a reality. Only when genomic databases are diverse can we ensure that we all benefit equally.

Genome 116
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Scribe and Sanofi partner to develop cell therapies for cancer

Pharmaceutical Technology

The alliance will leverage the CRISPR genome editing technologies of Scribe to facilitate in genetic modification of new natural killer (NK) cell therapeutics for cancer. Sanofi will also make tiered royalty payments on net sales of products resulting from the collaboration in the future.

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GSK and Wave Life Sciences partner to develop oligonucleotide therapeutics

Pharmaceutical Technology

The alliance will merge the PRISM oligonucleotide platform of Wave and the capabilities of GSK in genetics and genomics. Additionally, for WVE-006, GSK will make development and launch milestone payments of up to $225m to Wave, which is also eligible to get up to $300m in milestone payments based on sales.

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Scribe and Prevail partner for CRISPR-based genetic medicines

Pharmaceutical Technology

Prevail will pay for research funding and tiered royalties on net future sales while Scribe will have the right to opt-in to co-fund and share profits in the US on a single collaboration programme from the latest partnership. Scribe will receive $75m, including an upfront payment and equity investment via a convertible note.

Genetics 130
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More big wins for the AstraZeneca-Daiichi Sankyo collaboration

Pharmaceutical Technology

Enhertu has already achieved regulatory approval as a second-line therapy for metastatic or recurrent HER2-positive breast cancer, as well as HER2-positive gastric or gastroesophageal junction adenocarcinoma, with annual sales for these indications alone expected to exceed $1.3bn by 2028.

Sales 147
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Moderna partners with Life Edit for mRNA gene editing therapies

Pharmaceutical Technology

The company will also receive tiered royalties on the worldwide net sales of products developed from the collaboration. The company’s nuclease collection includes several Protospacer Adjacent Motifs (PAMs), short sequences that help determine the genome’s DNA segments.