Pharma Times

JANUARY 24, 2024

Patients living with sickle cell disease and thalassaemia will be eligible for the test

Genotype 106

Genotype 106

BioTech 365

NOVEMBER 23, 2021

FDA as the First and Only Treatment for People Ages 12 and Older with Post-Transplant Cytomegalovirus (CMV), Refractory (With or Without Genotypic Resistance) to Conventional Antiviral Therapies Takeda’s LIVTENCITYTM (maribavir) Approved by U.S. Takeda’s LIVTENCITYTM (maribavir) Approved by U.S. FDA … Continue reading →

Genotype 52

Genotype 52

BioTech 365

JUNE 11, 2021

thalassemia Continues to Demonstrate Durable Efficacy Across Pediatric and Adult Patient Populations and All Genotypes in Data Presented at EHA2021 Virtual betibeglogene autotemcel (beti-cel) One-Time Gene Therapy for ?-thalassemia betibeglogene autotemcel (beti-cel) One-Time Gene Therapy for ?-thalassemia

Genotype 52

Genotype Gene Therapy Gene 52

BioTech 365

DECEMBER 5, 2020

thalassemia Genotypes Achieve Transfusion Independence and Remain Free from Transfusions Up to Six Years Presented at 62nd ASH Meeting Long-Term Data for bluebird bio’s betibeglogene … Continue reading → Long-Term Data for bluebird bio’s betibeglogene autotemcel (beti-cel) Gene Therapy Show Patients Across Ages and ?-thalassemia

Genotype 52

Genotype Gene Therapy Gene 52

Medical Xpress

JANUARY 5, 2023

National Institutes of Health researchers have published an assessment of 13 studies that took a genotype-first approach to patient care. This approach contrasts with the typical phenotype-first approach to clinical research, which starts with clinical findings.

Genome 75

Genome Genomics Genetics Genotype 75

Scienmag

JUNE 10, 2021

Latest joint consensus guideline authored by representatives from AMP, CAP, Royal Dutch Pharmacists Association, and European Society for Pharmacogenomics and Personalized Therapy ROCKVILLE, Md.

Genotype 71

Genotype Medicine 71

Medical Xpress

MARCH 17, 2023

The use of DBS samples for HCV RNA detection and genotyping was shown to effectively assess cure after treatment and to differentiate between reinfection and treatment failure. A study with people who inject drugs evaluated a minimally invasive test based on dried blood spots (DBS) for the monitoring of hepatitis C virus (HCV) infection.

Genotype 82

Genotype RNA Drugs 82

Pharmaceutical Technology

SEPTEMBER 5, 2022

The treatment is indicated for CF patients who are homozygous for the F508del mutation (F/F genotype) in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. It enrolled 46 children aged one to under two years with the F/F genotype. According to the findings, Orkambi was found to be well tolerated.

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FDA Approval Genotype Clinical Trials Clinical Trials 130

Medical Xpress

FEBRUARY 3, 2023

For their paper published in the journal Science, Lorenzo Talamanca, Cédric Gobet and Felix Naef analyzed data obtained for the Genotype-Tissue Expression project. A trio of bioengineering scientists at Ecole Polytechnique Fédérale de Lausanne has found age and gender differences in gene expression related to the circadian clock.

Gene Expression 75

Gene Expression Gene Genotype Scientist 75

BioTech 365

JULY 20, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Untrained beer drinkers can taste different barley genotypes.When it comes to craft beer, the flavor doesn’t have to be all in the hops. As a panel of … Continue reading →

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Genotype Research 40

Medical Xpress

FEBRUARY 28, 2023

Using artificial intelligence (AI) methods, researchers led by Professor Dr. Alexander Schönhuth from Bielefeld University's Faculty of Technology have succeeded in recording and deciphering the genotype profiles of 3,000 ALS patients and thus learning more about the development of the disease.

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Genotype Development Research 75

Medical Xpress

MARCH 22, 2023

Fiber intake is associated with a lower risk of developing cognitive decline in those old people with the apolipoprotein E ApoE ε4 genotype, regarded as a genetic risk factor linked to the development of Alzheimer's disease.

Genotype 75

Genotype Pharmacy Genetics Development 75

The Pharma Data

SEPTEMBER 2, 2020

The decision allows use of the therapy in the EU in children as young as six years of age and weighing at least 17kg, regardless of HCV genotype or liver disease severity. Source link.

Genotype 52

Genotype Clinical Trials Clinical Trials Trials 52

Scienmag

APRIL 19, 2022

An estimated 100,000 Australians carry the high-risk genotype for Hemochromatosis, a condition affecting people of northern European descent which sees the body accumulate too much iron. It […].

Genetics 62

Genetics Genotype Research 62

Scienmag

JUNE 23, 2022

170 GWAS derived SNPs were genotyped on 3000 replication samples from participants in Ethiopia, Ghana, and […]. Orofacial clefts (OFCs) are congenital birth defects where the independently derived facial primordia that form the orofacial complex fail to fuse properly during embryonic development.

Genotype 58

Genotype Genome Genomics Development 58

Pharmaceutical Technology

JULY 4, 2022

Given subcutaneously, the antibody can hinder the entry of all ten HBV genotypes into hepatocytes and can also lower virion and subviral particle levels in the blood. A widely neutralising monoclonal antibody (mAb), VIR-3434 (BRII-877) acts on the hepatitis B virus (HBV). The mAb is presently in the Phase II development stage.

Antibody 279

Antibody Genotype Development Licensing 279

Scienmag

DECEMBER 15, 2020

Striving for a better understanding of pest resistance in experimental lines Credit: Gurjit Singh Tifton, Georgia: A study out of the University of Georgia sought to determine the level of host plant resistance that can be assured by several promising experimental bermudagrass genotypes against potential damages committed by the fall armyworm.

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Genotype Research Production 66

Scienmag

AUGUST 25, 2020

Credit: Iliana Baums, Penn State Coral conservation efforts could get a boost from a newly developed genotyping “chip”–the first of its kind for corals.

Genotype 66

Genotype Genetics Development Research 66

Scienmag

JANUARY 13, 2021

To discover these associations, researchers need to compare the genomes of many individuals at millions of genetic locations or markers, and therefore require cost-effective genotyping technologies. A new statistical method, developed […].

Genome 57

Genome Genomics Genotype Genetics 57

Worldwide Clinical Trials

FEBRUARY 6, 2023

The best course of action will depend on many variables, such as the disease or population being studied and the genotype/phenotype relationship, risk, and impact on care. Obtaining appropriate assistance to facilitate planning up front for the complexities involved will save sponsors time and effort in the long run.

Genetics 130

Genetics Clinical Trials Clinical Trials Genotype 130

Scienmag

MAY 16, 2021

The fully human monoclonal antibody produced sustained reductions in triglyceride levels of up to 82 percent, depending on the patient’s genotype, while also lowering the […].

Antibody 45

Antibody Genotype Drugs Clinical Trials 45

BioTech 365

JUNE 7, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Sensing what plants sense: Integrated framework helps scientists explain biology and predict crop performance.Scientists have invested great time and effort into making connections between a plant’s genotype, … Continue (..)

Scientist 40

Scientist Genotype Research 40

BioTech 365

OCTOBER 7, 2020

Enterprise’s novel TMEM16A potentiator portfolio includes ETD002, a first in class compound which is currently in Phase 1 TMEM16A potentiation is a novel therapeutic approach applicable to all cystic fibrosis patients, independent of CFTR genotype, and may provide benefit in … Continue reading →

Genotype 52

Genotype 52

BioTech 365

OCTOBER 7, 2020

Enterprise’s novel TMEM16A potentiator portfolio includes ETD002, a first in class compound which is currently in Phase 1 TMEM16A potentiation is a novel therapeutic approach applicable to all cystic fibrosis patients, independent of genotype, and may provide benefit in other … Continue reading →

Genotype 52

Genotype 52

BioTech 365

SEPTEMBER 10, 2020

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: GTEx Consortium releases fresh insights into how DNA differences govern gene expression.Scientists from the Genotype-Tissue Expression (GTEx) project, a National Institutes of Health-funded consortium including researchers from (..)

Gene Expression 40

Gene Expression DNA Gene Genotype 40

BioTech 365

OCTOBER 5, 2020

Despite advances in precision oncology, progress is slowed by the limitations of tissue genotyping, … Continue reading → Nature Medicine Publication Reports that Liquid Biopsy More Than Doubles Clinical Trial Enrollment Rate Compared to Tissue Biopsy REDWOOD CITY, Calif.–(BUSINESS Nasdaq: GH).

Clinical Trials 40

Clinical Trials Clinical Trials Genotype Trials 40

BioTech 365

AUGUST 17, 2020

ETD002 is a novel TMEM16A chloride channel potentiator Therapy applicable to all cystic fibrosis patients, independent of genotype BRIGHTON, England–(BUSINESS WIRE)–Enterprise Therapeutics Ltd (Enterprise), a biopharmaceutical company dedicated to the discovery and development of novel therapies to improve the lives … Continue reading (..)

Genotype 52

Genotype Trials Development 52

pharmaphorum

JANUARY 18, 2023

Pharmaceutical companies and biotechs are also adapting their approaches, launching patient finding and engagement programmes that can start years before clinical trials begin and allow them to run ‘recontact by genotype’ studies that the Resilience Project would have liked to do. Giving participants something in return.

Genetic Disease 97

Genetic Disease Genetics Research Genome 97

Delveinsight

DECEMBER 13, 2020

Hepatitis C treatment options, without a doubt, have improved significantly, including pan-genotypic medications that are used to treat all genotypes and subtypes. Typically, pan-genotypic treatments have high cure rates, few side effects, and short treatment durations (usually 8–12 weeks). and GT2 and GT3 with ribavirin.

Genotype 52

Genotype FDA Approval DNA Drugs 52

Pharmaceutical Technology

JUNE 6, 2023

Pharma Mar offers in vitro diagnostic products used for detection of virus and bacteria in respiratory infections and human papilloma virus genotypes, among others. Pharma Mar also offers kits used for diagnosis of influenza A and B and respiratory syncytial virus. Its development pipeline includes PM14 for solid tumors, among others.

Hormones 100

Hormones In-Vitro Genotype Bacteria 100

pharmaphorum

JANUARY 21, 2022

The findings have been submitted to the Genotype-to-Phenotype National Virology Consortium (G2P-UK), the New and Emerging Respiratory Virus Threats Advisory Group (NERVTAG) and the Joint Committee on Vaccination and Immunisation (JCVI). Overall, antibody levels were nearly 2.5

Antibody 113

Antibody Vaccination Vaccine Genotype 113

The Pharma Data

NOVEMBER 18, 2020

from Cedars-Sinai Medical Center in Los Angeles, and colleagues used whole-exome sequencing and genome-wide genotyping to determine the proportion of 792 IBD patients genetically at risk for TED and investigate the effect of the genetic risk for TED in IBD. WEDNESDAY, Nov. 21 in Gastroenterology. Takeo Naito, Ph.D.,

Genetics 52

Genetics Genotype Genome Genomics 52

The Pharma Data

FEBRUARY 1, 2021

On stratification by FADS genotype, the odds ratio was 0.49 (95 percent confidence interval, 0.31 The potential effect modification by FADS polymorphism (rs1535) was examined. Overall, the researchers found no evidence of an association between EPA plus DHA intake from fish with incident asthma in 4,543 participants.

Genotype 52

Genotype Doctor Doctors Research 52

pharmaphorum

JULY 13, 2021

Adding in genotype testing for ApoE4 – a well-established diagnostic biomarker for Alzheimer’s pushed the accuracy of the diagnosis up, but only a little to 90%, showing that the GPS monitoring was remarkably effective on its own.

Genotype 109

Genotype Scientist Drugs Research 109

Pharmaceutical Technology

DECEMBER 15, 2022

Therefore, there is also a significant need for new therapies that target the underlying cause of CFD that may offer a cure for patients living with severe disease, or for patients with genotypes such as dysfibrinogenemia and hypodysfibrinogenemia, who are often ineligible for treatment with HFCs.

Marketing 130

Marketing Production Genotype Development 130

Triage Cancer

JUNE 29, 2021

Tissue Genotyping. Genotype directed therapies. This program will cover a wide range of targeted therapy topics and discussions including the following, each of which will immediately be followed by a live Q&A with the audience: . Liquid Biopsies. Acquired Resistance. The role of IO therapy in driver positive patients.

Genotype 52

Genotype Doctor Doctors Research 52

pharmaphorum

JANUARY 16, 2023

Their work specifically focused on the effect of HRT on women with the APOE4 genotype. “Our research looked at associations with cognition and brain volumes using MRI scans,” noted Professor Minihane. “We did not look at dementia cases, but cognitive performance and lower brain volumes are predictive of future dementia risk.”

Hormones 73

Hormones Genotype Research Genetics 73