Medical Xpress

JANUARY 5, 2023

National Institutes of Health researchers have published an assessment of 13 studies that took a genotype-first approach to patient care. This approach contrasts with the typical phenotype-first approach to clinical research, which starts with clinical findings.

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Scienmag

JANUARY 13, 2021

To discover these associations, researchers need to compare the genomes of many individuals at millions of genetic locations or markers, and therefore require cost-effective genotyping technologies. A new statistical method, developed […].

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Medical Xpress

FEBRUARY 28, 2023

Using artificial intelligence (AI) methods, researchers led by Professor Dr. Alexander Schönhuth from Bielefeld University's Faculty of Technology have succeeded in recording and deciphering the genotype profiles of 3,000 ALS patients and thus learning more about the development of the disease.

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Worldwide Clinical Trials

FEBRUARY 6, 2023

The best course of action will depend on many variables, such as the disease or population being studied and the genotype/phenotype relationship, risk, and impact on care. Obtaining appropriate assistance to facilitate planning up front for the complexities involved will save sponsors time and effort in the long run. Read the full article!

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Scienmag

DECEMBER 15, 2020

Striving for a better understanding of pest resistance in experimental lines Credit: Gurjit Singh Tifton, Georgia: A study out of the University of Georgia sought to determine the level of host plant resistance that can be assured by several promising experimental bermudagrass genotypes against potential damages committed by the fall armyworm.

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Scienmag

AUGUST 25, 2020

Credit: Iliana Baums, Penn State Coral conservation efforts could get a boost from a newly developed genotyping “chip”–the first of its kind for corals.

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Scienmag

APRIL 19, 2022

New Edith Cowan University (ECU) research has identified a crucial link between arthritis and the risk of serious liver disease in people with Australia’s most common genetic condition.

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pharmaphorum

JANUARY 21, 2022

A third dose of vaccine has been shown to effectively neutralise the Omicron variant of covid-19, according to researchers. Research led by UCLH, UCL and the Francis Crick Institute found that the booster dose successfully stimulates antibody levels that neutralise Omicron. Details of the study were published in The Lancet this week.

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Worldwide Clinical Trials

AUGUST 14, 2024

Recent Advancements in Biomarker Research The latest advancements in biomarker research have further elevated the biomarker’s role in disease diagnosis, treatment, and monitoring. The analysis of circulating tumor DNA (ctDNA) in a liquid biopsy can also permit genotyping and help monitor the effectiveness of chemotherapy.

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BioTech 365

JULY 20, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Untrained beer drinkers can taste different barley genotypes.When it comes to craft beer, the flavor doesn’t have to be all in the hops. As a panel of … Continue reading →

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Worldwide Clinical Trials

DECEMBER 12, 2022

genotyping for known variants vs sequencing only vs sequencing and concurrent deletion/duplication analysis), and whether the interpretation of the genetic testing results may have changed over time. What is the difference between a Clinical Laboratory Improvement Amendments (CLIA)-approved laboratory vs a research laboratory?

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Clinical Trials Clinical Trials Genetics Trials 130

XTalks

MARCH 29, 2021

According to a study by researchers at the National Institutes of Health (NIH), moderate caffeine intake could lead to small babies. The research found that even consumption of less than the recommended moderate amount of 200 mg of caffeine per day for adults, which is about two cups of coffee, posed an increased risk to the fetus.

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BioTech 365

SEPTEMBER 10, 2020

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: GTEx Consortium releases fresh insights into how DNA differences govern gene expression.Scientists from the Genotype-Tissue Expression (GTEx) project, a National Institutes of Health-funded consortium including researchers from (..)

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BioTech 365

JUNE 7, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Sensing what plants sense: Integrated framework helps scientists explain biology and predict crop performance.Scientists have invested great time and effort into making connections between a plant’s genotype, … Continue (..)

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pharmaphorum

JANUARY 16, 2023

Hormone replacement therapy (HRT) could cut the risk of Alzheimer’s in some women at elevated risk of the disease, according to researchers in the UK. Their work specifically focused on the effect of HRT on women with the APOE4 genotype. The research is published in the journal Alzheimer’s Research and Therapy.

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Pharmaceutical Technology

DECEMBER 15, 2022

Therefore, there is also a significant need for new therapies that target the underlying cause of CFD that may offer a cure for patients living with severe disease, or for patients with genotypes such as dysfibrinogenemia and hypodysfibrinogenemia, who are often ineligible for treatment with HFCs.

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Delveinsight

DECEMBER 13, 2020

Research and development in Hepatitis. However, there is still a need for further research on HCV and the risk factors that lead to the progression of fibrosis, cirrhosis, and Hepatocellular carcinoma (HCC). Typically, pan-genotypic treatments have high cure rates, few side effects, and short treatment durations (usually 8–12 weeks).

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Genotype FDA Approval DNA Drugs 52

pharmaphorum

JANUARY 24, 2023

One of the reasons is because researchers now have far more genetic data to work with than was ever previously possible. With such a drop in cost, this means that researchers can test far more often and work with far more genetic data than previously possible. In this way, the company is able to generate drug targets.

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The Pharma Data

NOVEMBER 25, 2020

The researchers found that among MCI patients with and without progression to AD, there was no difference in age, gender, or years of education. WEDNESDAY, Nov. 29 to Dec. Of these patients, 72 and 267 progressed to AD and remained stable, respectively.

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The Pharma Data

NOVEMBER 18, 2020

from Cedars-Sinai Medical Center in Los Angeles, and colleagues used whole-exome sequencing and genome-wide genotyping to determine the proportion of 792 IBD patients genetically at risk for TED and investigate the effect of the genetic risk for TED in IBD. The researchers found that 122 of 792 IBD patients (15.4 Takeo Naito, Ph.D.,

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Genetics Genotype Genome Genomics 52

The Pharma Data

FEBRUARY 1, 2021

Overall, the researchers found no evidence of an association between EPA plus DHA intake from fish with incident asthma in 4,543 participants. On stratification by FADS genotype, the odds ratio was 0.49 (95 percent confidence interval, 0.31 The potential effect modification by FADS polymorphism (rs1535) was examined.

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Genotype Doctor Doctors Research 52

XTalks

APRIL 29, 2021

Proviral DNA Genotyping. In the HIV space, proviral DNA resistance testing is the newest genotypic resistance testing to be incorporated into the day-to-day management of patients living with HIV, explains Dr. Walworth. Importantly, ARV treatment does not affect the proviral DNA genome that persists in latently infected cells.

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XTalks

SEPTEMBER 28, 2020

Moreover, the test will also allow clinicians to monitor the evolution of a patient’s tumor genotype during the course of therapy through serial and almost real-time assessments; this will help to better guide treatment decisions and care.

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Gene DNA Life Science Genotype 105

pharmaphorum

NOVEMBER 10, 2021

“Better estimates of the burden of antimicrobial resistance in humans and animals depend on better microbiological data and more clarity on the appropriate design of epidemiological research. This database should support automatic importation from hospitals, laboratories and surveillance networks and link to genotypic data when available.”.

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Triage Cancer

JUNE 29, 2021

Tissue Genotyping. Genotype directed therapies. Online communities and how they support, educate and partner with research. This program will cover a wide range of targeted therapy topics and discussions including the following, each of which will immediately be followed by a live Q&A with the audience: . Liquid Biopsies.

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Genotype Doctor Doctors Research 52

The Pharma Data

NOVEMBER 2, 2020

ONWARD is investigating Adial’s lead drug candidate, AD04, as a therapeutic agent for the treatment of Alcohol Use Disorder (AUD) in persons with certain target genotypes related to the serotonin transporter and receptor genes. Key ONWARD highlights include: All 25 planned investigative sites are active.

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The Pharma Data

SEPTEMBER 8, 2021

The acquisition enables Roche to further expand the portfolio of currently over 45 CE-IVD assays and more than 100 research use assays on Roche`s LightCycler PCR instruments. TIB Molbiol is a biotech company that has supplied the global market with reagents for research and medical diagnostics for over 30 years. About TIB Molbiol.

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XTalks

APRIL 15, 2021

In their 2013 paper published in the journal Hypertension , an international team of researchers describe how they performed a GWAS study using data from over 22,000 individuals with coronary artery disease and over 64,000 controls. This increased study power comes at the cost of applicability and validity of results.

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Development Drugs Genomics Genome 98

Advarra

FEBRUARY 28, 2023

In an effort to accelerate the sharing of biomedical research results, the National Institutes of Health (NIH) issued its finalized Data Management and Sharing (DMS) policy , effective January 25, 2023. The policy statement supported reusing existing scientific data and accessibility of high value datasets for use in future research studies.

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XTalks

JANUARY 21, 2025

Unipure C3F8 Ophthalmic Gas, Unifeye Gas Delivery System, Unipexy Gas Delivery System Manufacturer/developer : Alcon Research, LLC Date of FDA approval : July 2, 2024 Approved for : Treating uncomplicated retinal detachments. Positive results prompt further diagnostic colonoscopy, while negative results support continued routine screening.

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XTalks

JANUARY 22, 2021

It identifies bacteria using both genotypic and phenotypic assessments within 1.5 Lee said, “Global research shows that 50 percent usage of antibiotics is inappropriate, and empirical treatment is one of the main causes. Empirical treatment usually gives two to three antibiotics at the same time to suppress unknown bacteria.”.

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The Pharma Data

NOVEMBER 10, 2020

Although a few are out there, phosphorylated tau (P-tau) may enable even earlier and more accurate detection, according to Eli Lilly-associated researchers speaking at the Clinical Trials on Alzheimer’s Disease (CTAD) virtual conference in early November. Tau biomarkers are useful in diagnosing Alzheimer’s disease, these researchers agreed.

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The Pharma Data

MARCH 16, 2022

Roche and its subsidiary, Tib Molbiol, confirm that it has tests for research use that identify the SARS-CoV-2 subvariants of concern, Omicron: BA.1, It’s critical to quickly and accurately identify variants to inform ongoing research – including the ongoing development of therapeutics and vaccines. 3 and Delta.

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XTalks

MARCH 3, 2021

Joffe, MD, director of the Office of Rare Diseases, Pediatrics, Urologic and Reproductive Medicine in the FDA’s Center for Drug Evaluation and Research, in a press announcement from the FDA. “Today’s action marks the first FDA approval for a therapy to treat this devastating disease,” said Hylton V.

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XTalks

DECEMBER 12, 2023

The world of neuroscience trials is rapidly evolving, presenting new challenges and opportunities for researchers and clinicians. This growth is primarily being driven by a rise in neurological diseases like stroke, dementia and peripheral neuropathy, coupled with increased R&D funding for neurological research. billion in 2022.

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The Pharma Data

JANUARY 26, 2021

Daniel Skovronsky, Lilly’s chief scientific officer and president of Lilly Research Laboratories, said the emergence of new variants of the virus calls for new strategies even while vaccination is ongoing in many parts of the world.

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Roots Analysis

APRIL 28, 2024

However, the rising incidence and prevalence of rare kidney disease, with poor outcomes and high cost has led to an increased research activity in this domain. Diagnosis, management, and treatment of such rare kidney diseases are complicated, especially when multi-system complications are present.

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